ENSDARG00000013422


Danio rerio

Features
Gene ID: ENSDARG00000013422
  
Biological name :slc8a1a
  
Synonyms : slc8a1a / solute carrier family 8 (sodium/calcium exchanger), member 1a
  
Possible biological names infered from orthology : P32418 / SLC8A1 / solute carrier family 8 member A1 / solute carrier family 8 (sodium/calcium exchanger), member 1
  
Species: Danio rerio
  
Chr. number: 11
Strand: -1
Band:
Gene start: 30535943
Gene end: 30612166
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000046799
Ensembl peptide - ENSDARP00000144549
Ensembl peptide - ENSDARP00000134979
Ensembl peptide - ENSDARP00000084236
NCBI entrez gene - 553489     See in Manteia.
RefSeq - NM_001037102
RefSeq Peptide - NP_001032179
swissprot - A0A0R4IH03
swissprot - F1R4F4
swissprot - F6PC65
swissprot - Q32SG8
swissprot - A0A286YBI0
swissprot - A0A0R4IK91
ZFIN ID - ZDB-GENE-050809-1
Ensembl - ENSDARG00000013422
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SLC8A1ENSGALG00000008544Gallus gallus
 P32418ENSG00000183023Homo sapiens
 Slc8a1ENSMUSG00000054640Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
slc8a1b / solute carrier family 8 (sodium/calcium exchanger), member 1b / SLC8A1* / P32418* / solute carrier family 8 member A1* / solute carrier family 8 (sodium/calcium exchanger), member 1*ENSDARG0000004340675
slc8a3 / solute carrier family 8 (sodium/calcium exchanger), member 3 / P57103* / S4R2P9* / solute carrier family 8 member A3*ENSDARG0000000493165
slc8a4a / solute carrier family 8 (sodium/calcium exchanger), member 4aENSDARG0000005515464
slc8a4b / solute carrier family 8 (sodium/calcium exchanger), member 4bENSDARG0000003714564
slc8a2b / solute carrier family 8 (sodium/calcium exchanger), member 2b / Q9UPR5* / SLC8A2* / Q8K596* / solute carrier family 8 member A2* / solute carrier family 8 (sodium/calcium exchange...ENSDARG0000010059261
slc8a2a / solute carrier family 8 (sodium/calcium exchanger), member 2a / Q9UPR5* / SLC8A2* / Q8K596* / solute carrier family 8 member A2* / solute carrier family 8 (sodium/calcium exchange...ENSDARG0000000891256
adgrv1 / adhesion G protein-coupled receptor V1 / Q8VHN7* / Q8WXG9*ENSDARG0000002113724


Protein motifs (from Interpro)
Interpro ID Name
 IPR003644  Na-Ca exchanger/integrin-beta4
 IPR004836  Sodium/calcium exchanger protein
 IPR004837  Sodium/calcium exchanger membrane region
 IPR032452  Sodium/calcium exchanger domain, C-terminal extension


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006816 calcium ion transport IMP
 biological_processGO:0006874 cellular calcium ion homeostasis IMP
 biological_processGO:0007154 cell communication IEA
 biological_processGO:0008016 regulation of heart contraction IMP
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0045214 sarcomere organization IMP
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 molecular_functionGO:0005432 calcium:sodium antiporter activity IMP


Pathways (from Reactome)
Pathway description
Reduction of cytosolic Ca++ levels
Sodium/Calcium exchangers
Ion homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle morphology , abnormal
cardiac ventricle decreased size , abnormal
cardiac ventricle collapsed , abnormal
cardiac ventricle myofibril decreased thickness , abnormal
cardiac ventricle sarcomere irregular spatial pattern , abnormal
cardiac ventricle sarcomere decreased amount , abnormal
cardiac ventricle Z disc morphology , abnormal
cardiac ventricle quality , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000114 heart heart contractility , abnormal
heart decreased functionality , abnormal
heart quality , abnormal
heart physical object quality , abnormal
heart decreased size , abnormal
heart spatial pattern , ameliorated
heart increased amount , abnormal
heart increased distribution , abnormal
Show

 ZFA:0000471 atrium atrium morphology , abnormal
atrium contractility , abnormal
atrium collapsed , abnormal
Show

 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism viability , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
Show

 ZFA:0001319 myocardium myocardium uncoordinated , abnormal
Show

 ZFA:0001439 anatomical system anatomical system quality , abnormal
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 ZFA:0009316 cardiac muscle cell cardiac muscle cell shape , abnormal
cardiac muscle cell decreased length , abnormal
cardiac muscle cell sarcomere structure , ameliorated
cardiac muscle cell sarcomere disorganized , abnormal
cardiac muscle cell sarcomere disassembled , abnormal
cardiac muscle cell Z disc amount , ameliorated
cardiac muscle cell Z disc decreased amount , abnormal
cardiac muscle cell cardiac myofibril disorganized , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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