ENSG00000183023


Homo sapiens

Features
Gene ID: ENSG00000183023
  
Biological name :SLC8A1
  
Synonyms : P32418 / SLC8A1 / solute carrier family 8 member A1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p22.1
Gene start: 40097270
Gene end: 40611053
  
Corresponding Affymetrix probe sets: 1556583_a_at (Human Genome U133 Plus 2.0 Array)   1561614_at (Human Genome U133 Plus 2.0 Array)   1561615_s_at (Human Genome U133 Plus 2.0 Array)   1564985_a_at (Human Genome U133 Plus 2.0 Array)   1565306_a_at (Human Genome U133 Plus 2.0 Array)   207053_at (Human Genome U133 Plus 2.0 Array)   210804_x_at (Human Genome U133 Plus 2.0 Array)   211805_s_at (Human Genome U133 Plus 2.0 Array)   235518_at (Human Genome U133 Plus 2.0 Array)   238546_at (Human Genome U133 Plus 2.0 Array)   241752_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000386116
Ensembl peptide - ENSP00000385811
Ensembl peptide - ENSP00000389330
Ensembl peptide - ENSP00000412560
Ensembl peptide - ENSP00000398575
Ensembl peptide - ENSP00000332931
Ensembl peptide - ENSP00000383886
Ensembl peptide - ENSP00000384763
Ensembl peptide - ENSP00000384908
Ensembl peptide - ENSP00000385188
Ensembl peptide - ENSP00000385535
Ensembl peptide - ENSP00000385678
NCBI entrez gene - 6546     See in Manteia.
OMIM - 182305
RefSeq - XM_017004763
RefSeq - XM_017004752
RefSeq - XM_017004753
RefSeq - XM_017004754
RefSeq - XM_017004755
RefSeq - XM_017004756
RefSeq - XM_017004757
RefSeq - XM_017004758
RefSeq - XM_017004759
RefSeq - XM_017004760
RefSeq - XM_017004761
RefSeq - XM_017004762
RefSeq - NM_001112800
RefSeq - NM_001112801
RefSeq - NM_001112802
RefSeq - NM_001252624
RefSeq - NM_021097
RefSeq - XM_005264514
RefSeq - XM_006712081
RefSeq - XM_006712082
RefSeq - XM_006712083
RefSeq - XM_006712084
RefSeq - XM_006712085
RefSeq - XM_011533050
RefSeq - XM_011533054
RefSeq - XM_011533055
RefSeq - XM_011533056
RefSeq - XM_011533057
RefSeq - XM_011533058
RefSeq - XM_017004745
RefSeq - XM_017004746
RefSeq - XM_017004747
RefSeq - XM_017004748
RefSeq - XM_017004749
RefSeq - XM_017004750
RefSeq - XM_017004751
RefSeq Peptide - NP_001106271
RefSeq Peptide - NP_001106272
RefSeq Peptide - NP_001106273
RefSeq Peptide - NP_001239553
RefSeq Peptide - NP_066920
RefSeq Peptide - NP_001338422
RefSeq Peptide - NP_001338423
swissprot - P32418
swissprot - E9PB98
swissprot - E9PCL8
swissprot - E7EV41
Ensembl - ENSG00000183023
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc8a1aENSDARG00000013422Danio rerio
 slc8a1bENSDARG00000043406Danio rerio
 SLC8A1ENSGALG00000008544Gallus gallus
 Slc8a1ENSMUSG00000054640Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P57103 / SLC8A3 / solute carrier family 8 member A3ENSG0000010067869
Q9UPR5 / SLC8A2 / solute carrier family 8 member A2ENSG0000011816063
ADGRV1 / Q8WXG9 / adhesion G protein-coupled receptor V1ENSG0000016419927


Protein motifs (from Interpro)
Interpro ID Name
 IPR001623  DnaJ domain
 IPR002987  Sodium/calcium exchanger, isoform 1
 IPR003644  Na-Ca exchanger/integrin-beta4
 IPR004836  Sodium/calcium exchanger protein
 IPR004837  Sodium/calcium exchanger membrane region
 IPR032452  Sodium/calcium exchanger domain, C-terminal extension


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0002026 regulation of the force of heart contraction ISS
 biological_processGO:0002027 regulation of heart rate ISS
 biological_processGO:0002028 regulation of sodium ion transport IEA
 biological_processGO:0006811 ion transport TAS
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0006883 cellular sodium ion homeostasis IDA
 biological_processGO:0006936 muscle contraction TAS
 biological_processGO:0007154 cell communication IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010649 regulation of cell communication by electrical coupling TAS
 biological_processGO:0010763 positive regulation of fibroblast migration IEA
 biological_processGO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion TAS
 biological_processGO:0010882 regulation of cardiac muscle contraction by calcium ion signaling TAS
 biological_processGO:0014829 vascular smooth muscle contraction ISS
 biological_processGO:0021537 telencephalon development IEA
 biological_processGO:0030501 positive regulation of bone mineralization IMP
 biological_processGO:0033198 response to ATP IEA
 biological_processGO:0035725 sodium ion transmembrane transport IMP
 biological_processGO:0035902 response to immobilization stress IEA
 biological_processGO:0035994 response to muscle stretch IMP
 biological_processGO:0036376 sodium ion export across plasma membrane IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0044557 relaxation of smooth muscle ISS
 biological_processGO:0051481 negative regulation of cytosolic calcium ion concentration ISS
 biological_processGO:0051924 regulation of calcium ion transport IEA
 biological_processGO:0055013 cardiac muscle cell development ISS
 biological_processGO:0055074 calcium ion homeostasis ISS
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0055119 relaxation of cardiac muscle TAS
 biological_processGO:0060048 cardiac muscle contraction TAS
 biological_processGO:0060078 regulation of postsynaptic membrane potential IEA
 biological_processGO:0060401 cytosolic calcium ion transport TAS
 biological_processGO:0060402 calcium ion transport into cytosol ISS
 biological_processGO:0070509 calcium ion import IDA
 biological_processGO:0070588 calcium ion transmembrane transport IGI
 biological_processGO:0071313 cellular response to caffeine ISS
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0086012 membrane depolarization during cardiac muscle cell action potential TAS
 biological_processGO:0086064 cell communication by electrical coupling involved in cardiac conduction ISS
 biological_processGO:0098719 sodium ion import across plasma membrane IDA
 biological_processGO:0098735 positive regulation of the force of heart contraction IMP
 biological_processGO:1903779 regulation of cardiac conduction TAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0014704 intercalated disc TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030018 Z disc ISS
 cellular_componentGO:0030315 T-tubule TAS
 cellular_componentGO:0042383 sarcolemma ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043198 dendritic shaft IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0005432 calcium:sodium antiporter activity TAS
 molecular_functionGO:0005509 calcium ion binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0008092 cytoskeletal protein binding IDA
 molecular_functionGO:0015297 antiporter activity IEA
 molecular_functionGO:0030506 ankyrin binding ISS
 molecular_functionGO:0044325 ion channel binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential IEA


Pathways (from Reactome)
Pathway description
Reduction of cytosolic Ca++ levels
Sodium/Calcium exchangers
Ion homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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