ENSG00000100678


Homo sapiens

Features
Gene ID: ENSG00000100678
  
Biological name :SLC8A3
  
Synonyms : P57103 / SLC8A3 / solute carrier family 8 member A3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q24.2
Gene start: 70044217
Gene end: 70189070
  
Corresponding Affymetrix probe sets: 1562403_a_at (Human Genome U133 Plus 2.0 Array)   1568859_a_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000437103
Ensembl peptide - ENSP00000436332
Ensembl peptide - ENSP00000436688
Ensembl peptide - ENSP00000216568
Ensembl peptide - ENSP00000349392
Ensembl peptide - ENSP00000350560
Ensembl peptide - ENSP00000370669
Ensembl peptide - ENSP00000377863
Ensembl peptide - ENSP00000433531
NCBI entrez gene - 6547     See in Manteia.
OMIM - 607991
RefSeq - XM_017021611
RefSeq - NM_001130417
RefSeq - NM_033262
RefSeq - NM_058240
RefSeq - NM_182932
RefSeq - NM_182936
RefSeq - NM_183002
RefSeq - XM_006720240
RefSeq - XM_017021606
RefSeq - XM_017021607
RefSeq - XM_017021608
RefSeq - XM_017021609
RefSeq Peptide - NP_891981
RefSeq Peptide - NP_891977
RefSeq Peptide - NP_892114
RefSeq Peptide - NP_001123889
RefSeq Peptide - NP_150287
RefSeq Peptide - NP_489479
swissprot - P57103
swissprot - F2Z391
Ensembl - ENSG00000100678
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc8a3ENSDARG00000004931Danio rerio
 SLC8A3ENSGALG00000009400Gallus gallus
 S4R2P9ENSMUSG00000079055Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P32418 / SLC8A1 / solute carrier family 8 member A1ENSG0000018302372
Q9UPR5 / SLC8A2 / solute carrier family 8 member A2ENSG0000011816070
ADGRV1 / Q8WXG9 / adhesion G protein-coupled receptor V1ENSG0000016419927


Protein motifs (from Interpro)
Interpro ID Name
 IPR003644  Na-Ca exchanger/integrin-beta4
 IPR004836  Sodium/calcium exchanger protein
 IPR004837  Sodium/calcium exchanger membrane region
 IPR032452  Sodium/calcium exchanger domain, C-terminal extension


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IEA
 biological_processGO:0006811 ion transport TAS
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006851 mitochondrial calcium ion transmembrane transport ISS
 biological_processGO:0006874 cellular calcium ion homeostasis ISS
 biological_processGO:0007154 cell communication IEA
 biological_processGO:0007612 learning ISS
 biological_processGO:0007613 memory ISS
 biological_processGO:0014819 regulation of skeletal muscle contraction ISS
 biological_processGO:0021537 telencephalon development IEA
 biological_processGO:0030001 metal ion transport IEA
 biological_processGO:0035725 sodium ion transmembrane transport ISS
 biological_processGO:0042552 myelination ISS
 biological_processGO:0048709 oligodendrocyte differentiation ISS
 biological_processGO:0051560 mitochondrial calcium ion homeostasis ISS
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060078 regulation of postsynaptic membrane potential IEA
 biological_processGO:0060291 long-term synaptic potentiation ISS
 biological_processGO:0060402 calcium ion transport into cytosol IEA
 biological_processGO:0070588 calcium ion transmembrane transport ISS
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0071456 cellular response to hypoxia ISS
 biological_processGO:0098703 calcium ion import across plasma membrane IEA
 biological_processGO:1903779 regulation of cardiac conduction TAS
 biological_processGO:1990034 calcium ion export across plasma membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane ISS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISS
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016528 sarcoplasm IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031226 intrinsic component of plasma membrane IDA
 cellular_componentGO:0031594 neuromuscular junction ISS
 cellular_componentGO:0042383 sarcolemma ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005432 calcium:sodium antiporter activity TAS
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0015297 antiporter activity IEA
 molecular_functionGO:0015368 calcium:cation antiporter activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential IEA


Pathways (from Reactome)
Pathway description
Reduction of cytosolic Ca++ levels
Sodium/Calcium exchangers
Ion homeostasis
Mitochondrial calcium ion transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000121057 AKAP1 / Q92667 / A-kinase anchoring protein 1  / complex






 

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