ENSMUSG00000079055


Mus musculus

Features
Gene ID: ENSMUSG00000079055
  
Biological name :Slc8a3
  
Synonyms : S4R2P9 / Slc8a3 / solute carrier family 8 (sodium/calcium exchanger), member 3
  
Possible biological names infered from orthology : P57103 / solute carrier family 8 member A3
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: D1
Gene start: 81197915
Gene end: 81333180
  
Corresponding Affymetrix probe sets: 10401296 (MoGene1.0st)   1440962_at (Mouse Genome 430 2.0 Array)   1450311_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000063258
Ensembl peptide - ENSMUSP00000082334
Ensembl peptide - ENSMUSP00000138735
Ensembl peptide - ENSMUSP00000138803
NCBI entrez gene - 110893     See in Manteia.
MGI - MGI:107976
RefSeq - XM_006515414
RefSeq - NM_001167920
RefSeq - NM_080440
RefSeq - XM_006515411
RefSeq - XM_006515412
RefSeq - XM_006515413
RefSeq Peptide - NP_001161392
RefSeq Peptide - NP_536688
swissprot - S4R2V4
swissprot - E9PX50
swissprot - S4R2P9
Ensembl - ENSMUSG00000079055
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc8a3ENSDARG00000004931Danio rerio
 SLC8A3ENSGALG00000009400Gallus gallus
 P57103ENSG00000100678Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Slc8a1 / solute carrier family 8 (sodium/calcium exchanger), member 1 / P32418* / solute carrier family 8 member A1*ENSMUSG0000005464072
Q8K596 / Slc8a2 / solute carrier family 8 (sodium/calcium exchanger), member 2 / Q9UPR5* / solute carrier family 8 member A2*ENSMUSG0000003037668
Adgrv1 / Q8VHN7 / adhesion G protein-coupled receptor V1 / Q8WXG9*ENSMUSG0000006917026


Protein motifs (from Interpro)
Interpro ID Name
 IPR003644  Na-Ca exchanger/integrin-beta4
 IPR004836  Sodium/calcium exchanger protein
 IPR004837  Sodium/calcium exchanger membrane region
 IPR032452  Sodium/calcium exchanger domain, C-terminal extension


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006851 mitochondrial calcium ion transmembrane transport IMP
 biological_processGO:0006874 cellular calcium ion homeostasis IMP
 biological_processGO:0007154 cell communication IEA
 biological_processGO:0007612 learning IMP
 biological_processGO:0007613 memory IMP
 biological_processGO:0014819 regulation of skeletal muscle contraction IMP
 biological_processGO:0021537 telencephalon development IEA
 biological_processGO:0030001 metal ion transport IDA
 biological_processGO:0035725 sodium ion transmembrane transport IMP
 biological_processGO:0042552 myelination IMP
 biological_processGO:0048709 oligodendrocyte differentiation IMP
 biological_processGO:0051560 mitochondrial calcium ion homeostasis IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060078 regulation of postsynaptic membrane potential IEA
 biological_processGO:0060291 long-term synaptic potentiation IMP
 biological_processGO:0060402 calcium ion transport into cytosol IEA
 biological_processGO:0070588 calcium ion transmembrane transport IMP
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0071456 cellular response to hypoxia IDA
 biological_processGO:0098703 calcium ion import across plasma membrane IEA
 biological_processGO:1990034 calcium ion export across plasma membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016528 sarcoplasm IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031226 intrinsic component of plasma membrane IEA
 cellular_componentGO:0031594 neuromuscular junction IDA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005432 calcium:sodium antiporter activity IMP
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0015297 antiporter activity IEA
 molecular_functionGO:0015368 calcium:cation antiporter activity IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential IMP


Pathways (from Reactome)
Pathway description
Reduction of cytosolic Ca++ levels
Sodium/Calcium exchangers
Ion homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dmc1tm1Tkm/Dmc1tm1Tkm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc6a3tm1b(KOMP)Wtsi/Slc6a3+
Genetic Background: C57BL/6N-Slc6a3tm1b(KOMP)Wtsi/J

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dmc1tm1Tkm/Dmc1tm1Tkm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002899 fatigue "easily exhausted due to mental or physical exertion" [hdene:Howard Dene , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dmc1tm1Tkm/Dmc1tm1Tkm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003484 abnormal channel response "anomalies in the electrophysiological recordings from ion channels" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Dmc1tm1Tkm/Dmc1tm1Tkm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003635 abnormal synaptic transmission "defect in the communication from a neuron to a target across a synapse " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dmc1tm1Tkm/Dmc1tm1Tkm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Slc6a3tm1b(KOMP)Wtsi/Slc6a3+
Genetic Background: C57BL/6N-Slc6a3tm1b(KOMP)Wtsi/J

 MP:0006060 increased cerebral infarction size "increased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dmc1tm1Tkm/Dmc1tm1Tkm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009414 skeletal muscle fiber necrosis "pathological cell death in the skeletal muscle fibers, usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmc1tm1Tkm/Dmc1tm1Tkm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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