ENSMUSG00000069170


Mus musculus

Features
Gene ID: ENSMUSG00000069170
  
Biological name :Adgrv1
  
Synonyms : Adgrv1 / adhesion G protein-coupled receptor V1 / Q8VHN7
  
Possible biological names infered from orthology : Q8WXG9
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: C3
Gene start: 81095068
Gene end: 81633154
  
Corresponding Affymetrix probe sets: 10410778 (MoGene1.0st)   1421693_a_at (Mouse Genome 430 2.0 Array)   1425314_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123552
Ensembl peptide - ENSMUSP00000122358
Ensembl peptide - ENSMUSP00000153419
Ensembl peptide - ENSMUSP00000093245
Ensembl peptide - ENSMUSP00000105193
Ensembl peptide - ENSMUSP00000114579
Ensembl peptide - ENSMUSP00000120136
Ensembl peptide - ENSMUSP00000121899
NCBI entrez gene - 110789     See in Manteia.
MGI - MGI:1274784
RefSeq - XM_017315372
RefSeq - XM_017315364
RefSeq - XM_017315365
RefSeq - XM_017315366
RefSeq - XM_017315367
RefSeq - XM_017315368
RefSeq - XM_017315369
RefSeq - XM_017315370
RefSeq - XM_017315371
RefSeq - NM_054053
RefSeq - XM_017315363
RefSeq Peptide - NP_473394
swissprot - G5E8P3
swissprot - D3YYF1
swissprot - B8JJE0
swissprot - Q8BPQ5
swissprot - Q8C1E5
swissprot - F6X844
swissprot - Q8VHN7
Ensembl - ENSMUSG00000069170
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adgrv1ENSDARG00000021137Danio rerio
 ENSGALG00000043556Gallus gallus
 ENSGALG00000032066Gallus gallus
 ADGRV1ENSG00000164199Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
S4R2P9 / Slc8a3 / solute carrier family 8 (sodium/calcium exchanger), member 3 / P57103* / solute carrier family 8 member A3*ENSMUSG000000790554
Slc8a1 / solute carrier family 8 (sodium/calcium exchanger), member 1 / P32418* / solute carrier family 8 member A1*ENSMUSG000000546404
Q8K596 / Slc8a2 / solute carrier family 8 (sodium/calcium exchanger), member 2 / Q9UPR5* / solute carrier family 8 member A2*ENSMUSG000000303764


Protein motifs (from Interpro)
Interpro ID Name
 IPR000203  GPS motif
 IPR000832  GPCR, family 2, secretin-like
 IPR003644  Na-Ca exchanger/integrin-beta4
 IPR005492  Leucine-rich glioma-inactivated , EPTP repeat
 IPR006558  LamG-like jellyroll fold
 IPR009039  EAR
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR017981  GPCR, family 2-like
 IPR026919  G protein-coupled receptor 98


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007154 cell communication IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development NAS
 biological_processGO:0007601 visual perception IMP
 biological_processGO:0007605 sensory perception of sound ISO
 biological_processGO:0010739 positive regulation of protein kinase A signaling IDA
 biological_processGO:0045184 establishment of protein localization IMP
 biological_processGO:0045494 photoreceptor cell maintenance ISO
 biological_processGO:0048496 maintenance of animal organ identity ISO
 biological_processGO:0048839 inner ear development IMP
 biological_processGO:0050877 nervous system process ISO
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0050910 detection of mechanical stimulus involved in sensory perception of sound IMP
 biological_processGO:0050953 sensory perception of light stimulus ISO
 biological_processGO:0060122 inner ear receptor cell stereocilium organization IMP
 biological_processGO:0071277 cellular response to calcium ion IDA
 biological_processGO:0098609 cell-cell adhesion NAS
 cellular_componentGO:0002141 stereocilia ankle link IDA
 cellular_componentGO:0002142 stereocilia ankle link complex IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032391 photoreceptor connecting cilium IDA
 cellular_componentGO:0032420 stereocilium IEA
 cellular_componentGO:0043235 receptor complex ISO
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:1990075 periciliary membrane compartment IDA
 cellular_componentGO:1990696 USH2 complex IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005509 calcium ion binding NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017022 myosin binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000043 organ of Corti degeneration "a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adgrv1tm1Pwh/Adgrv1tm1Pwh
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Prdm9repro7/Prdm9repro7
Genetic Background: B6;C3Fe-Prdm9repro7/J

Allelic Composition: Adgrv1tm1.1(KOMP)Vlcg/Adgrv1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Adgrv1tm1.1(KOMP)Vlcg/Ucd

 MP:0001496 audiogenic seizures "a reflex seizure triggered by loud noises" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rab3atm1Sud/Rab3aEbd
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Adgrv1tm1Pwh/Adgrv1tm1Pwh
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Adgrv1tm1Msat/Adgrv1tm1Msat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Adgrv1tm1Msat/Adgrv1tm1Msat
Genetic Background: B6.129P2-Adgrv1tm1Msat

Allelic Composition: Adgrv1frings/Adgrv1frings
Genetic Background: BUB/BnJ

 MP:0001967 deafness "inability to hear" [J:57651]
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Allelic Composition: Adgrv1tm1Pwh/Adgrv1tm1Pwh
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Adgrv1frings/Adgrv1frings,Cdh23ahl/Cdh23ahl
Genetic Background: involves: BUB/BnJ * CAST/EiJ

Allelic Composition: Adgrv1frings/Adgrv1frings,Cdh23ahl/Cdh23ahl
Genetic Background: involves: BUB/BnJ * MOLD/RkJ

Allelic Composition: Adgrv1frings/Adgrv1frings
Genetic Background: BUB/BnJ

Allelic Composition: Cdh23ahl/Cdh23ahl,Adgrv1frings/Adgrv1frings
Genetic Background: involves: BUB/BnJ * RB/1

Allelic Composition: Adgrv1mpc188H/Adgrv1mpc188H
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0002090 abnormal vision "inability or decreased ability to see " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adgrv1tm1Pwh/Adgrv1tm1Pwh
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Adgrv1frings/Adgrv1frings
Genetic Background: BUB/BnJ

 MP:0003146 absent cochlear ganglion "absence of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [J:36834, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Gmnntm1Nyma/Gmnntm1Nyma
Genetic Background: involves: C57BL/6

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Adgrv1tm1Pwh/Adgrv1tm1Pwh
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004362 cochlear hair cell degeneration "degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adgrv1frings/Adgrv1frings
Genetic Background: BUB/BnJ

 MP:0004398 cochlear inner hair cell degeneration "degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adgrv1tm1Pwh/Adgrv1tm1Pwh
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adgrv1tm1Pwh/Adgrv1tm1Pwh
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Adgrv1tm2Msat/Adgrv1tm2Msat
Genetic Background: involves: 129P2/OlaHsd

 MP:0004431 abnormal hair cell mechanoelectric transduction "anomalous conversion of mechanical energy into electric(al) energy by sensory cells, such as auditory and vestibular hair cells, required for auditory sensation" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adgrv1tm1Pwh/Adgrv1tm1Pwh
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Adgrv1tm1Msat/Adgrv1tm1Msat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004434 abnormal cochlear outer hair cell physiology "anomalies in processes pertinent to the function of cochlear OHCs which are known to enhance the performance of the cochlea, both qualitatively (increased selectivity) and quantitatively (increased sensitivity); in addition to the mechanoelectric transduction required for auditory sensation, OHCs also perform electromechanical transduction, whereby transmembrane voltage drives rapid changes in the length and stiffness of OHCs at audio frequencies in vitro (electromotility)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adgrv1tm1Pwh/Adgrv1tm1Pwh
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Adgrv1tm1Msat/Adgrv1tm1Msat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004491 abnormal orientation of outer hair cell stereociliary bundles "misorientation or rotation of outer hair cell (OHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adgrv1tm1Pwh/Adgrv1tm1Pwh
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Adgrv1rueda/Adgrv1rueda
Genetic Background: involves: C57BL/6J

 MP:0004521 abnormal cochlear hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical pattern of arrangement of mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adgrv1tm1Pwh/Adgrv1tm1Pwh
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Adgrv1tm1Msat/Adgrv1tm1Msat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004527 abnormal outer hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical V or W-like pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear OHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest (outermost) row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adgrv1tm1Pwh/Adgrv1tm1Pwh
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Adgrv1tm1Msat/Adgrv1tm1Msat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Adgrv1frings/Adgrv1frings
Genetic Background: BUB/BnJ

Allelic Composition: Adgrv1tm2Msat/Adgrv1tm2Msat
Genetic Background: involves: 129P2/OlaHsd

 MP:0004532 abnormal inner hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typically linear or U-shaped pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear IHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adgrv1tm1Pwh/Adgrv1tm1Pwh
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Adgrv1tm1Msat/Adgrv1tm1Msat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004577 abnormal cochlear hair cell inter-stereocilial links "any structural abnormality in the morphologically and biochemically distinct link types that extend between the stereocilia of cochlear hair bundles; link types can be distinguished by their relative sensitivities to treatment with calcium chelators and the protease subtilisin; in the mature mouse cochlea, tip links and horizontal top connectors are the only inter-stereocilial links associated with the hair bundle; ankle links and transient lateral links are both prominent features of developing auditory hair bundles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adgrv1tm2Msat/Adgrv1tm2Msat
Genetic Background: involves: 129P2/OlaHsd

 MP:0004582 absent cochlear hair bundle ankle links "absence of the long, single-stranded filaments that form a dense web or mesh around the base of cochlear hair bundles just above the region in which the stereocilia begin to taper down" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adgrv1tm1Pwh/Adgrv1tm1Pwh
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Adgrv1tm1Msat/Adgrv1tm1Msat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004586 pillar cell degeneration "degeneration or loss of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Adgrv1tm1Pwh/Adgrv1tm1Pwh
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004737 absent distortion product otoacoustic emissions "failure to create mechanical distortions in the inner ear when two primary tones are presented, indicating failure of outer hair cells to amplify basilar membrane motion" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Adgrv1tm1Pwh/Adgrv1tm1Pwh
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Adgrv1tm2Msat/Adgrv1tm2Msat
Genetic Background: involves: 129P2/OlaHsd

 MP:0004748 increased susceptibility to age-related hearing loss "greater than normal loss of hearing associated with advancing age, manifest as reduced ability to perceive or discriminate sounds; the pattern and age of onset vary" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adgrv1frings/Adgrv1frings
Genetic Background: BUB/BnJ

Allelic Composition: Cdh23ahl/Cdh23ahl,Adgrv1frings/Adgrv1frings
Genetic Background: involves: BUB/BnJ * RB/1

 MP:0006359 absent startle reflex "failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adgrv1tm1.1(KOMP)Vlcg/Adgrv1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Adgrv1tm1.1(KOMP)Vlcg/Ucd

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Adgrv1tm1.1(KOMP)Vlcg/Adgrv1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Adgrv1tm1.1(KOMP)Vlcg/Ucd

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adgrv1tm1Pwh/Adgrv1tm1Pwh
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Adgrv1tm1Msat/Adgrv1tm1Msat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Adgrv1tm1Msat/Adgrv1tm1Msat
Genetic Background: B6.129P2-Adgrv1tm1Msat

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Adgrv1tm1Pwh/Adgrv1tm1Pwh
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Adgrv1frings/Adgrv1frings
Genetic Background: BUB/BnJ

Allelic Composition: Adgrv1rueda/Adgrv1rueda
Genetic Background: involves: C57BL/6J

Allelic Composition: Adgrv1tm2Msat/Adgrv1tm2Msat
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Adgrv1tm1.1(KOMP)Vlcg/Adgrv1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Adgrv1tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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