ENSDARG00000014218


Danio rerio

Features
Gene ID: ENSDARG00000014218
  
Biological name :mecp2
  
Synonyms : mecp2 / methyl CpG binding protein 2
  
Possible biological names infered from orthology : P51608 / Q9Z2D6
  
Species: Danio rerio
  
Chr. number: 8
Strand: -1
Band:
Gene start: 7616573
Gene end: 7637640
  
Corresponding Affymetrix probe sets: Dr.20599.1.S1_at (Zebrafish Array)   NM_212736_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000109399
Ensembl peptide - ENSDARP00000040671
NCBI entrez gene - 335250     See in Manteia.
RefSeq - NM_212736
RefSeq - NM_001328555
RefSeq Peptide - NP_001315484
RefSeq Peptide - NP_997901
swissprot - A8WIP2
swissprot - Q7T2T7
ZFIN ID - ZDB-GENE-030131-7190
Ensembl - ENSDARG00000014218
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MECP2ENSG00000169057Homo sapiens
 Mecp2ENSMUSG00000031393Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mbd4 / methyl-CpG binding domain protein 4 / O95243* / methyl-CpG binding domain 4, DNA glycosylase*ENSDARG000001102983


Protein motifs (from Interpro)
Interpro ID Name
 IPR001739  Methyl-CpG DNA binding
 IPR016177  DNA-binding domain superfamily
 IPR017353  Methyl-CpG binding protein MeCP2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007528 neuromuscular junction development IMP
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0009314 response to radiation IBA
 biological_processGO:0045664 regulation of neuron differentiation IMP
 biological_processGO:0061564 axon development IMP
 biological_processGO:0099054 presynapse assembly IGI
 cellular_componentGO:0000792 heterochromatin IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0008327 methyl-CpG binding IBA
 molecular_functionGO:0010385 double-stranded methylated DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain has fewer parts of type neuron , abnormal
brain has extra parts of type neuronal stem cell , abnormal
brain has extra parts of type astrocyte , abnormal
brain Notch signaling pathway increased occurrence , abnormal
brain neuron differentiation decreased occurrence , abnormal
brain astrocyte differentiation increased occurrence , abnormal
brain neural precursor cell proliferation increased occurrence , abnormal
brain neuronal stem cell proliferative , abnormal
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 ZFA:0000037 anatomical structure anatomical structure increased amount , abnormal
anatomical structure decreased amount , abnormal
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 ZFA:0000295 trigeminal ganglion trigeminal ganglion has fewer parts of type motor neuron , abnormal
trigeminal ganglion axon decreased length , abnormal
trigeminal ganglion axon arborization disrupted , abnormal
trigeminal ganglion axon branchiness , abnormal
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 ZFA:0001056 myotome myotome neuromuscular junction increased distribution , abnormal
myotome presynaptic density increased amount , abnormal
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 ZFA:0001094 whole organism whole organism increased amount , abnormal
whole organism decreased amount , abnormal
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 ZFA:0001291 facial ganglion facial ganglion has fewer parts of type motor neuron , abnormal
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 ZFA:0007067 vagal ganglion vagal ganglion has fewer parts of type motor neuron , abnormal
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 ZFA:0009150 Rohon-Beard neuron Rohon-Beard neuron axon decreased length , abnormal
Rohon-Beard neuron axon decreased branchiness , abnormal
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 ZFA:0009243 CaP motoneuron CaP motoneuron axonogenesis disrupted , abnormal
CaP motoneuron axon morphology , abnormal
CaP motoneuron axon decreased branchiness , abnormal
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 ZFA:0009247 secondary motor neuron secondary motor neuron axon morphology , abnormal
secondary motor neuron axon decreased branchiness , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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