ENSDARG00000014230


Danio rerio

Features
Gene ID: ENSDARG00000014230
  
Biological name :dlst
  
Synonyms : dihydrolipoamide S-succinyltransferase / dlst
  
Possible biological names infered from orthology : Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial / P36957 / Q9D2G2
  
Species: Danio rerio
  
Chr. number: 17
Strand: 1
Band:
Gene start: 52524355
Gene end: 52553447
  
Corresponding Affymetrix probe sets: Dr.3786.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000006973
NCBI entrez gene - 368262     See in Manteia.
RefSeq - NM_201487
RefSeq Peptide - NP_958895
swissprot - F1QFQ6
ZFIN ID - ZDB-GENE-030326-1
Ensembl - ENSDARG00000014230
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DLSTENSGALG00000010286Gallus gallus
 DLSTENSG00000119689Homo sapiens
 DlstENSMUSG00000004789Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
dbt / dihydrolipoamide branched chain transacylase E2 / P11182* / P53395* / Mus musculus dihydrolipoamide branched chain transacylase E2 (Dbt), transcript variant 2, mRNA.*ENSDARG0000010156124


Protein motifs (from Interpro)
Interpro ID Name
 IPR000089  Biotin/lipoyl attachment
 IPR001078  2-oxoacid dehydrogenase acyltransferase, catalytic domain
 IPR003016  2-oxo acid dehydrogenase, lipoyl-binding site
 IPR006255  Dihydrolipoamide succinyltransferase
 IPR011053  Single hybrid motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006099 tricarboxylic acid cycle IEA
 biological_processGO:0006754 ATP biosynthetic process IMP
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0060047 heart contraction IMP
 biological_processGO:0070584 mitochondrion morphogenesis IMP
 cellular_componentGO:0045252 oxoglutarate dehydrogenase complex IEA
 molecular_functionGO:0004149 dihydrolipoyllysine-residue succinyltransferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA


Pathways (from Reactome)
Pathway description
Glyoxylate metabolism and glycine degradation
Lysine catabolism
Citric acid cycle (TCA cycle)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood accumulation sinus venosus , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000112 gut gut hypoplastic , abnormal
gut quality , abnormal
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 ZFA:0001078 thymus thymus amount , ameliorated
thymus increased amount , abnormal
thymus decreased amount , abnormal
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 ZFA:0001094 whole organism whole organism precursor T-cell lymphoblastic lymphoma/leukaemia has fewer parts of type cell , ameliorated
whole organism precursor T-cell lymphoblastic lymphoma/leukaemia onset quality , ameliorated
whole organism decreased size , abnormal
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 ZFA:0001114 head head decreased width , abnormal
head pointed , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton protruding , abnormal
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 ZFA:0001273 ventral mandibular arch ventral mandibular arch quality , abnormal
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 ZFA:0001319 myocardium myocardium mitochondrion disorganized , abnormal
myocardium mitochondrial crista decreased amount , abnormal
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 ZFA:0005070 atrioventricular node atrioventricular node decreased functionality , abnormal
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 ZFA:0005277 skeletal muscle skeletal muscle mitochondrion structure , abnormal
skeletal muscle mitochondrion vacuolated , abnormal
skeletal muscle mitochondrial crista decreased amount , abnormal
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 ZFA:0009046 T cell T cell cell cycle delayed , ameliorated
T cell cell proliferation occurrence , ameliorated
Show

 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte decreased amount , abnormal
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 ZFA:0009316 cardiac muscle cell cardiac muscle cell decreased contractility , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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