ENSG00000119689


Homo sapiens

Features
Gene ID: ENSG00000119689
  
Biological name :DLST
  
Synonyms : dihydrolipoamide S-succinyltransferase / DLST / P36957
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q24.3
Gene start: 74881891
Gene end: 74903745
  
Corresponding Affymetrix probe sets: 215210_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000451957
Ensembl peptide - ENSP00000452417
Ensembl peptide - ENSP00000487251
Ensembl peptide - ENSP00000452422
Ensembl peptide - ENSP00000238671
Ensembl peptide - ENSP00000335304
Ensembl peptide - ENSP00000451210
Ensembl peptide - ENSP00000451425
Ensembl peptide - ENSP00000451670
NCBI entrez gene - 1743     See in Manteia.
OMIM - 126063
RefSeq - NM_001244883
RefSeq - NM_001933
RefSeq Peptide - NP_001231812
RefSeq Peptide - NP_001924
swissprot - G3V5L9
swissprot - G3V5M3
swissprot - H0YJF9
swissprot - P36957
swissprot - B7ZAZ8
swissprot - Q86SW4
swissprot - A0A024R6C9
swissprot - G3V3F0
swissprot - G3V498
Ensembl - ENSG00000119689
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dlstENSDARG00000014230Danio rerio
 DLSTENSGALG00000010286Gallus gallus
 DlstENSMUSG00000004789Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DBT / P11182 / dihydrolipoamide branched chain transacylase E2ENSG0000013799226


Protein motifs (from Interpro)
Interpro ID Name
 IPR000089  Biotin/lipoyl attachment
 IPR001078  2-oxoacid dehydrogenase acyltransferase, catalytic domain
 IPR003016  2-oxo acid dehydrogenase, lipoyl-binding site
 IPR006255  Dihydrolipoamide succinyltransferase
 IPR011053  Single hybrid motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006091 generation of precursor metabolites and energy TAS
 biological_processGO:0006099 tricarboxylic acid cycle TAS
 biological_processGO:0006103 2-oxoglutarate metabolic process ISS
 biological_processGO:0006104 succinyl-CoA metabolic process ISS
 biological_processGO:0006554 lysine catabolic process TAS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine IEA
 biological_processGO:0034641 cellular nitrogen compound metabolic process TAS
 biological_processGO:0106077 histone succinylation IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005739 mitochondrion HDA
 cellular_componentGO:0005759 mitochondrial matrix TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0045252 oxoglutarate dehydrogenase complex IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004149 dihydrolipoyllysine-residue succinyltransferase activity ISS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA


Pathways (from Reactome)
Pathway description
Glyoxylate metabolism and glycine degradation
Lysine catabolism
Citric acid cycle (TCA cycle)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000091140 DLD / P09622 / dihydrolipoamide dehydrogenase  / complex
 ENSG00000105953 OGDH / Q02218 / oxoglutarate dehydrogenase  / complex
 ENSG00000119689 DLST / P36957 / dihydrolipoamide S-succinyltransferase  / complex
 ENSG00000140905 GCSH / P23434 / glycine cleavage system protein H  / reaction






 

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