ENSMUSG00000004789


Mus musculus

Features
Gene ID: ENSMUSG00000004789
  
Biological name :Dlst
  
Synonyms : Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial / Dlst / Q9D2G2
  
Possible biological names infered from orthology : dihydrolipoamide S-succinyltransferase / P36957
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: D1
Gene start: 85110833
Gene end: 85134845
  
Corresponding Affymetrix probe sets: 10397311 (MoGene1.0st)   1423710_at (Mouse Genome 430 2.0 Array)   1430161_at (Mouse Genome 430 2.0 Array)   1431011_at (Mouse Genome 430 2.0 Array)   1437775_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152664
Ensembl peptide - ENSMUSP00000060346
Ensembl peptide - ENSMUSP00000152235
NCBI entrez gene - 78920     See in Manteia.
MGI - MGI:1926170
RefSeq - NM_030225
RefSeq - XM_006516392
RefSeq - XM_017315247
RefSeq Peptide - NP_084501
swissprot - A0A1Y7VN44
swissprot - Q9D2G2
Ensembl - ENSMUSG00000004789
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dlstENSDARG00000014230Danio rerio
 DLSTENSGALG00000010286Gallus gallus
 DLSTENSG00000119689Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dbt / P53395 / Mus musculus dihydrolipoamide branched chain transacylase E2 (Dbt), transcript variant 2, mRNA. / P11182* / dihydrolipoamide branched chain transacylase E2*ENSMUSG0000000034024


Protein motifs (from Interpro)
Interpro ID Name
 IPR000089  Biotin/lipoyl attachment
 IPR001078  2-oxoacid dehydrogenase acyltransferase, catalytic domain
 IPR003016  2-oxo acid dehydrogenase, lipoyl-binding site
 IPR006255  Dihydrolipoamide succinyltransferase
 IPR011053  Single hybrid motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006099 tricarboxylic acid cycle IEA
 biological_processGO:0006103 2-oxoglutarate metabolic process ISS
 biological_processGO:0006104 succinyl-CoA metabolic process ISS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine IEA
 biological_processGO:0106077 histone succinylation ISS
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0045252 oxoglutarate dehydrogenase complex IEA
 molecular_functionGO:0004149 dihydrolipoyllysine-residue succinyltransferase activity ISS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA


Pathways (from Reactome)
Pathway description
Glyoxylate metabolism and glycine degradation
Lysine catabolism
Citric acid cycle (TCA cycle)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg,Tg(TCF/Lef1-lacZ)34Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg,Tg(TCF/Lef1-lacZ)34Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003329 amyloid beta deposits 
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Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg,Tg(TCF/Lef1-lacZ)34Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020664 Dld / O08749 / Dihydrolipoyl dehydrogenase, mitochondrial / P09622* / dihydrolipoamide dehydrogenase*  / complex
 ENSMUSG00000034424 Gcsh / Q91WK5 / Glycine cleavage system H protein, mitochondrial / P23434* / AC092718.3* / AC092718.8* / glycine cleavage system protein H*  / reaction
 ENSMUSG00000004789 Dlst / Q9D2G2 / Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial / P36957* / dihydrolipoamide S-succinyltransferase*  / complex
 ENSMUSG00000020456 Ogdh / Q60597 / 2-oxoglutarate dehydrogenase, mitochondrial / Q02218* / oxoglutarate dehydrogenase*  / complex






 

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