ENSMUSG00000020456


Mus musculus

Features
Gene ID: ENSMUSG00000020456
  
Biological name :Ogdh
  
Synonyms : 2-oxoglutarate dehydrogenase, mitochondrial / Ogdh / Q60597
  
Possible biological names infered from orthology : oxoglutarate dehydrogenase / Q02218
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A1
Gene start: 6291633
Gene end: 6356642
  
Corresponding Affymetrix probe sets: 10374119 (MoGene1.0st)   1445632_at (Mouse Genome 430 2.0 Array)   1451274_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117323
Ensembl peptide - ENSMUSP00000117505
Ensembl peptide - ENSMUSP00000003461
Ensembl peptide - ENSMUSP00000091041
Ensembl peptide - ENSMUSP00000099090
Ensembl peptide - ENSMUSP00000080569
NCBI entrez gene - 18293     See in Manteia.
MGI - MGI:1098267
RefSeq - NM_001252288
RefSeq - NM_010956
RefSeq - XM_006514586
RefSeq - XM_017314337
RefSeq - XM_006514585
RefSeq - XM_006514582
RefSeq - XM_006514583
RefSeq - XM_006514584
RefSeq - NM_001252282
RefSeq - NM_001252283
RefSeq - NM_001252287
RefSeq Peptide - NP_001239212
RefSeq Peptide - NP_001239211
RefSeq Peptide - NP_001239216
RefSeq Peptide - NP_001239217
RefSeq Peptide - NP_035086
swissprot - Q60597
swissprot - Q5SVY1
swissprot - Q5SVY0
swissprot - Z4YJV4
Ensembl - ENSMUSG00000020456
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ogdhaENSDARG00000034270Danio rerio
 ogdhbENSDARG00000103428Danio rerio
 OGDHENSGALG00000014155Gallus gallus
 OGDHENSG00000105953Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ogdhl / oxoglutarate dehydrogenase-like / Q9ULD0*ENSMUSG0000002191372
A2ATU0 / Dhtkd1 / Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial / Q96HY7* / dehydrogenase E1 and transketolase domain containing 1*ENSMUSG0000002581533


Protein motifs (from Interpro)
Interpro ID Name
 IPR001017  Dehydrogenase, E1 component
 IPR005475  Transketolase-like, pyrimidine-binding domain
 IPR011603  2-oxoglutarate dehydrogenase E1 component
 IPR029061  Thiamin diphosphate-binding fold
 IPR031717  Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal
 IPR032106  2-oxoglutarate dehydrogenase E1 component, N-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006091 generation of precursor metabolites and energy ISS
 biological_processGO:0006096 glycolytic process IEA
 biological_processGO:0006099 tricarboxylic acid cycle IEA
 biological_processGO:0006103 2-oxoglutarate metabolic process ISS
 biological_processGO:0006104 succinyl-CoA metabolic process ISS
 biological_processGO:0006734 NADH metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0021695 cerebellar cortex development IEP
 biological_processGO:0021756 striatum development IEP
 biological_processGO:0021766 hippocampus development IEP
 biological_processGO:0021794 thalamus development IEP
 biological_processGO:0021860 pyramidal neuron development IEP
 biological_processGO:0022028 tangential migration from the subventricular zone to the olfactory bulb IEP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0061034 olfactory bulb mitral cell layer development IEP
 biological_processGO:0106077 histone succinylation ISS
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0031966 mitochondrial membrane ISS
 cellular_componentGO:0045252 oxoglutarate dehydrogenase complex ISS
 molecular_functionGO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor IEA
 molecular_functionGO:0030976 thiamine pyrophosphate binding IEA
 molecular_functionGO:0031072 heat shock protein binding IEA
 molecular_functionGO:0034602 oxoglutarate dehydrogenase (NAD+) activity IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051087 chaperone binding IEA


Pathways (from Reactome)
Pathway description
Glyoxylate metabolism and glycine degradation
Lysine catabolism
Citric acid cycle (TCA cycle)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ltatm1.1(KOMP)Vlcg/Ltatm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ltatm1.1(KOMP)Vlcg/Ucd

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Ltatm1.1(KOMP)Vlcg/Ltatm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ltatm1.1(KOMP)Vlcg/Ucd

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ltatm1.1(KOMP)Vlcg/Ltatm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ltatm1.1(KOMP)Vlcg/Ucd

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Ltatm1.1(KOMP)Vlcg/Ltatm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ltatm1.1(KOMP)Vlcg/Ucd

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Nampttm1.1(KOMP)Vlcg/Nampttm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Nampttm1.1(KOMP)Vlcg/Ucd

 MP:0013971 blood in lymph vessels 
Show

Allelic Composition: Ltatm1.1(KOMP)Vlcg/Ltatm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ltatm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020664 Dld / O08749 / Dihydrolipoyl dehydrogenase, mitochondrial / P09622* / dihydrolipoamide dehydrogenase*  / complex
 ENSMUSG00000034424 Gcsh / Q91WK5 / Glycine cleavage system H protein, mitochondrial / P23434* / AC092718.3* / AC092718.8* / glycine cleavage system protein H*  / reaction
 ENSMUSG00000020456 Ogdh / Q60597 / 2-oxoglutarate dehydrogenase, mitochondrial / Q02218* / oxoglutarate dehydrogenase*  / complex
 ENSMUSG00000004789 Dlst / Q9D2G2 / Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial / P36957* / dihydrolipoamide S-succinyltransferase*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr