ENSMUSG00000034424


Mus musculus

Features
Gene ID: ENSMUSG00000034424
  
Biological name :Gcsh
  
Synonyms : Gcsh / Glycine cleavage system H protein, mitochondrial / Q91WK5
  
Possible biological names infered from orthology : AC092718.3 / AC092718.8 / glycine cleavage system protein H / P23434
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: E1
Gene start: 116981810
Gene end: 116993537
  
Corresponding Affymetrix probe sets: 10582020 (MoGene1.0st)   1432164_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037131
NCBI entrez gene - 68133     See in Manteia.
MGI - MGI:1915383
RefSeq - NM_026572
RefSeq Peptide - NP_080848
swissprot - Q91WK5
Ensembl - ENSMUSG00000034424
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gcshaENSDARG00000091655Danio rerio
 gcshbENSDARG00000105187Danio rerio
 GCSHENSGALG00000032679Gallus gallus
 AC092718.3ENSG00000260643Homo sapiens
 AC092718.8ENSG00000284512Homo sapiens
 GCSHENSG00000140905Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000089  Biotin/lipoyl attachment
 IPR002930  Glycine cleavage system H-protein
 IPR003016  2-oxo acid dehydrogenase, lipoyl-binding site
 IPR011053  Single hybrid motif
 IPR017453  Glycine cleavage system H-protein, subgroup
 IPR033753  Glycine cleavage system H-protein/Simiate


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009249 protein lipoylation ISO
 biological_processGO:0019464 glycine decarboxylation via glycine cleavage system IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005960 glycine cleavage complex IEA


Pathways (from Reactome)
Pathway description
Glyoxylate metabolism and glycine degradation
Glycine degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000340 Dbt / P53395 / Mus musculus dihydrolipoamide branched chain transacylase E2 (Dbt), transcript variant 2, mRNA. / P11182* / dihydrolipoamide branched chain transacylase E2*  / reaction
 ENSMUSG00000020456 Ogdh / Q60597 / 2-oxoglutarate dehydrogenase, mitochondrial / Q02218* / oxoglutarate dehydrogenase*  / reaction
 ENSMUSG00000010914 Pdhx / Q8BKZ9 / Pyruvate dehydrogenase protein X component, mitochondrial / O00330* / pyruvate dehydrogenase complex component X*  / reaction
 ENSMUSG00000021748 Pdhb / Q9D051 / Pyruvate dehydrogenase E1 component subunit beta, mitochondrial / P11177* / pyruvate dehydrogenase E1 beta subunit*  / reaction
 ENSMUSG00000024827 Gldc / Q91W43 / Glycine dehydrogenase (decarboxylating), mitochondrial / P23378* / glycine decarboxylase*  / reaction
 ENSMUSG00000025815 A2ATU0 / Dhtkd1 / Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial / Q96HY7* / dehydrogenase E1 and transketolase domain containing 1*  / reaction
 ENSMUSG00000031299 Pdha1 / P35486 / pyruvate dehydrogenase E1 alpha 1 / P08559* / pyruvate dehydrogenase E1 alpha 1 subunit*  / reaction
 ENSMUSG00000032263 Bckdhb / Q6P3A8 / 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial / P21953* / branched chain keto acid dehydrogenase E1 subunit beta*  / reaction
 ENSMUSG00000032607 Amt / Q8CFA2 / Aminomethyltransferase, mitochondrial / P48728* / aminomethyltransferase*  / reaction
 ENSMUSG00000000168 Dlat / Q8BMF4 / Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial / P10515* / dihydrolipoamide S-acetyltransferase*  / reaction
 ENSMUSG00000030869 Q9CR21 / Ndufab1 / NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1 / O14561* / NADH:ubiquinone oxidoreductase subunit AB1*  / reaction
 ENSMUSG00000029199 Lias / Q99M04 / Lipoyl synthase, mitochondrial / O43766* / lipoic acid synthetase*  / reaction
 ENSMUSG00000004789 Dlst / Q9D2G2 / Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial / P36957* / dihydrolipoamide S-succinyltransferase*  / reaction
 ENSMUSG00000060376 Bckdha / branched chain ketoacid dehydrogenase E1, alpha polypeptide / P12694* / branched chain keto acid dehydrogenase E1, alpha polypeptide*  / reaction
 ENSMUSG00000047674 Pdha2 / P35487 / Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial / P29803* / pyruvate dehydrogenase E1 alpha 2 subunit*  / reaction
 ENSMUSG00000020664 Dld / O08749 / Dihydrolipoyl dehydrogenase, mitochondrial / P09622* / dihydrolipoamide dehydrogenase*  / reaction






 

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