ENSMUSG00000047674


Mus musculus

Features
Gene ID: ENSMUSG00000047674
  
Biological name :Pdha2
  
Synonyms : P35487 / Pdha2 / Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
  
Possible biological names infered from orthology : P29803 / pyruvate dehydrogenase E1 alpha 2 subunit
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: H1
Gene start: 141210004
Gene end: 141212355
  
Corresponding Affymetrix probe sets: 10502446 (MoGene1.0st)   1450962_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000060774
NCBI entrez gene - 18598     See in Manteia.
MGI - MGI:97533
RefSeq - NM_008811
RefSeq Peptide - NP_032837
swissprot - P35487
Ensembl - ENSMUSG00000047674
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdha1aENSDARG00000012387Danio rerio
 pdha1bENSDARG00000010555Danio rerio
 PDHA1ENSGALG00000016430Gallus gallus
 PDHA2ENSG00000163114Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pdha1 / P35486 / pyruvate dehydrogenase E1 alpha 1 / P08559* / pyruvate dehydrogenase E1 alpha 1 subunit*ENSMUSG0000003129976
Bckdha / branched chain ketoacid dehydrogenase E1, alpha polypeptide / P12694* / branched chain keto acid dehydrogenase E1, alpha polypeptide*ENSMUSG0000006037625


Protein motifs (from Interpro)
Interpro ID Name
 IPR001017  Dehydrogenase, E1 component
 IPR017597  Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y
 IPR029061  Thiamin diphosphate-binding fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0006086 acetyl-CoA biosynthetic process from pyruvate IEA
 biological_processGO:0006090 pyruvate metabolic process IEA
 biological_processGO:0006099 tricarboxylic acid cycle IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate ISO
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0045254 pyruvate dehydrogenase complex IEA
 molecular_functionGO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity ISS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor IEA
 molecular_functionGO:0034604 pyruvate dehydrogenase (NAD+) activity ISO


Pathways (from Reactome)
Pathway description
Regulation of pyruvate dehydrogenase (PDH) complex
Glyoxylate metabolism and glycine degradation
Signaling by Retinoic Acid
Pyruvate metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006494 Pdk1 / Q8BFP9 / [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial / Q15118* / pyruvate dehydrogenase kinase 1*  / reaction
 ENSMUSG00000019577 Pdk4 / O70571 / pyruvate dehydrogenase kinase, isoenzyme 4 / Q16654* / pyruvate dehydrogenase kinase 4*  / reaction
 ENSMUSG00000031299 Pdha1 / P35486 / pyruvate dehydrogenase E1 alpha 1 / P08559* / pyruvate dehydrogenase E1 alpha 1 subunit*  / complex
 ENSMUSG00000038967 Pdk2 / Q9JK42 / [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial / Q15119* / pyruvate dehydrogenase kinase 2*  / reaction
 ENSMUSG00000035232 Pdk3 / Q922H2 / pyruvate dehydrogenase kinase, isoenzyme 3 / Q15120* / pyruvate dehydrogenase kinase 3*  / reaction
 ENSMUSG00000020664 Dld / O08749 / Dihydrolipoyl dehydrogenase, mitochondrial / P09622* / dihydrolipoamide dehydrogenase*  / complex
 ENSMUSG00000010914 Pdhx / Q8BKZ9 / Pyruvate dehydrogenase protein X component, mitochondrial / O00330* / pyruvate dehydrogenase complex component X*  / complex
 ENSMUSG00000000168 Dlat / Q8BMF4 / Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial / P10515* / dihydrolipoamide S-acetyltransferase*  / complex
 ENSMUSG00000021748 Pdhb / Q9D051 / Pyruvate dehydrogenase E1 component subunit beta, mitochondrial / P11177* / pyruvate dehydrogenase E1 beta subunit*  / complex
 ENSMUSG00000047674 Pdha2 / P35487 / Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial / P29803* / pyruvate dehydrogenase E1 alpha 2 subunit*  / complex
 ENSMUSG00000034424 Gcsh / Q91WK5 / Glycine cleavage system H protein, mitochondrial / P23434* / AC092718.3* / AC092718.8* / glycine cleavage system protein H*  / reaction






 

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