ENSMUSG00000019577


Mus musculus

Features
Gene ID: ENSMUSG00000019577
  
Biological name :Pdk4
  
Synonyms : O70571 / Pdk4 / pyruvate dehydrogenase kinase, isoenzyme 4
  
Possible biological names infered from orthology : pyruvate dehydrogenase kinase 4 / Q16654
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: A1
Gene start: 5483351
Gene end: 5496309
  
Corresponding Affymetrix probe sets: 10543017 (MoGene1.0st)   1417273_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145377
Ensembl peptide - ENSMUSP00000019721
NCBI entrez gene - 27273     See in Manteia.
MGI - MGI:1351481
RefSeq - NM_013743
RefSeq Peptide - NP_038771
swissprot - A0A0N4SW53
swissprot - O70571
swissprot - Q544J2
Ensembl - ENSMUSG00000019577
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdk4ENSDARG00000054848Danio rerio
 PDK4ENSGALG00000009700Gallus gallus
 PDK4ENSG00000004799Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pdk2 / Q9JK42 / [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial / Q15119* / pyruvate dehydrogenase kinase 2*ENSMUSG0000003896765
Pdk1 / Q8BFP9 / [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial / Q15118* / pyruvate dehydrogenase kinase 1*ENSMUSG0000000649464
Pdk3 / Q922H2 / pyruvate dehydrogenase kinase, isoenzyme 3 / Q15120* / pyruvate dehydrogenase kinase 3*ENSMUSG0000003523261
Bckdk / O55028 / [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial / O14874* / branched chain ketoacid dehydrogenase kinase*ENSMUSG0000003080227


Protein motifs (from Interpro)
Interpro ID Name
 IPR003594  Histidine kinase/HSP90-like ATPase
 IPR005467  Histidine kinase domain
 IPR018955  Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
 IPR036784  Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily
 IPR036890  Histidine kinase/HSP90-like ATPase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006885 regulation of pH IMP
 biological_processGO:0008286 insulin receptor signaling pathway IMP
 biological_processGO:0009267 cellular response to starvation IEA
 biological_processGO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate IMP
 biological_processGO:0010565 regulation of cellular ketone metabolic process IMP
 biological_processGO:0010906 regulation of glucose metabolic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0042304 regulation of fatty acid biosynthetic process IEA
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0042594 response to starvation IMP
 biological_processGO:0045124 regulation of bone resorption IMP
 biological_processGO:0046320 regulation of fatty acid oxidation IMP
 biological_processGO:0071398 cellular response to fatty acid IEA
 biological_processGO:0072593 reactive oxygen species metabolic process IEA
 biological_processGO:2000811 negative regulation of anoikis IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity TAS
 molecular_functionGO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity ISO
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Regulation of pyruvate dehydrogenase (PDH) complex
Signaling by Retinoic Acid


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tnfsf11tles/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Apoc1tm1Lmh/Apoc1tm1Lmh,Tg(CETP)5203Tall/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoc1tm1Lmh/Apoc1tm1Lmh,Tg(CETP)5203Tall/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoc1tm1Lmh/Apoc1tm1Lmh,Tg(CETP)5203Tall/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J

 MP:0002575 increased circulating ketone body level "greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968]
Show

Allelic Composition: Apoc1tm1Lmh/Apoc1tm1Lmh,Tg(CETP)5203Tall/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J

 MP:0003439 abnormal glycerol level "anomalous concentration of this molecule, the backbone of lipids, which is important for gluconeogenesis during starvation" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95278]
Show

Allelic Composition: Apoc1tm1Lmh/Apoc1tm1Lmh,Tg(CETP)5203Tall/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfsf11tles/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0004983 abnormal osteoclast cell number "deviation from the average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfsf11tles/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Apoc1tm1Lmh/Apoc1tm1Lmh,Tg(CETP)5203Tall/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
Show

Allelic Composition: Apoc1tm1Lmh/Apoc1tm1Lmh,Tg(CETP)5203Tall/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J

 MP:0005439 decreased glycogen level "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoc1tm1Lmh/Apoc1tm1Lmh,Tg(CETP)5203Tall/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apoc1tm1Lmh/Apoc1tm1Lmh,Tg(CETP)5203Tall/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfsf11tles/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0009345 abnormal cancellous bone thickness "anomaly in the width of bone that has a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfsf11tles/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoc1tm1Lmh/Apoc1tm1Lmh,Tg(CETP)5203Tall/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J

 MP:0010874 abnormal bone volume "any anomaly in the amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfsf11tles/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0010877 abnormal trabecular bone volume "any anomaly in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfsf11tles/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0013404 decreased circulating lactate level "reduced amount of lactate in the blood which is produced from pyruvate by lactate dehydrogenase" [MPD:Molly]
Show

Allelic Composition: Apoc1tm1Lmh/Apoc1tm1Lmh,Tg(CETP)5203Tall/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021748 Pdhb / Q9D051 / Pyruvate dehydrogenase E1 component subunit beta, mitochondrial / P11177* / pyruvate dehydrogenase E1 beta subunit*  / reaction
 ENSMUSG00000031299 Pdha1 / P35486 / pyruvate dehydrogenase E1 alpha 1 / P08559* / pyruvate dehydrogenase E1 alpha 1 subunit*  / reaction
 ENSMUSG00000047674 Pdha2 / P35487 / Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial / P29803* / pyruvate dehydrogenase E1 alpha 2 subunit*  / reaction
 ENSMUSG00000020664 Dld / O08749 / Dihydrolipoyl dehydrogenase, mitochondrial / P09622* / dihydrolipoamide dehydrogenase*  / reaction
 ENSMUSG00000010914 Pdhx / Q8BKZ9 / Pyruvate dehydrogenase protein X component, mitochondrial / O00330* / pyruvate dehydrogenase complex component X*  / reaction
 ENSMUSG00000000168 Dlat / Q8BMF4 / Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial / P10515* / dihydrolipoamide S-acetyltransferase*  / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr