ENSMUSG00000038967


Mus musculus

Features
Gene ID: ENSMUSG00000038967
  
Biological name :Pdk2
  
Synonyms : Pdk2 / [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial / Q9JK42
  
Possible biological names infered from orthology : pyruvate dehydrogenase kinase 2 / Q15119
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 95026258
Gene end: 95041354
  
Corresponding Affymetrix probe sets: 10390103 (MoGene1.0st)   1448825_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041447
NCBI entrez gene - 18604     See in Manteia.
MGI - MGI:1343087
RefSeq - NM_133667
RefSeq - XM_006532457
RefSeq Peptide - NP_598428
swissprot - Q9JK42
Ensembl - ENSMUSG00000038967
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdk2aENSDARG00000020876Danio rerio
 pdk2bENSDARG00000059054Danio rerio
 ENSGALG00000045846Gallus gallus
 PDK2ENSG00000005882Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pdk3 / Q922H2 / pyruvate dehydrogenase kinase, isoenzyme 3 / Q15120* / pyruvate dehydrogenase kinase 3*ENSMUSG0000003523268
Pdk1 / Q8BFP9 / [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial / Q15118* / pyruvate dehydrogenase kinase 1*ENSMUSG0000000649468
Pdk4 / O70571 / pyruvate dehydrogenase kinase, isoenzyme 4 / Q16654* / pyruvate dehydrogenase kinase 4*ENSMUSG0000001957766
Bckdk / O55028 / [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial / O14874* / branched chain ketoacid dehydrogenase kinase*ENSMUSG0000003080228


Protein motifs (from Interpro)
Interpro ID Name
 IPR003594  Histidine kinase/HSP90-like ATPase
 IPR005467  Histidine kinase domain
 IPR018955  Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
 IPR036784  Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily
 IPR036890  Histidine kinase/HSP90-like ATPase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0006111 regulation of gluconeogenesis IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006885 regulation of pH IMP
 biological_processGO:0008286 insulin receptor signaling pathway IMP
 biological_processGO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate IMP
 biological_processGO:0010565 regulation of cellular ketone metabolic process IMP
 biological_processGO:0010906 regulation of glucose metabolic process IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0031670 cellular response to nutrient IMP
 biological_processGO:0034614 cellular response to reactive oxygen species IEA
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005967 mitochondrial pyruvate dehydrogenase complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Regulation of pyruvate dehydrogenase (PDH) complex
Signaling by Retinoic Acid


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002841 impaired skeletal muscle contractility "inability or reduced ability of the skeletal muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ndrg1str/Ndrg1str
Genetic Background: involves: BALB/c * C57BL/6 * NOD/ShiLtWtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000047674 Pdha2 / P35487 / Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial / P29803* / pyruvate dehydrogenase E1 alpha 2 subunit*  / reaction
 ENSMUSG00000021748 Pdhb / Q9D051 / Pyruvate dehydrogenase E1 component subunit beta, mitochondrial / P11177* / pyruvate dehydrogenase E1 beta subunit*  / reaction
 ENSMUSG00000000168 Dlat / Q8BMF4 / Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial / P10515* / dihydrolipoamide S-acetyltransferase*  / reaction
 ENSMUSG00000020664 Dld / O08749 / Dihydrolipoyl dehydrogenase, mitochondrial / P09622* / dihydrolipoamide dehydrogenase*  / reaction
 ENSMUSG00000010914 Pdhx / Q8BKZ9 / Pyruvate dehydrogenase protein X component, mitochondrial / O00330* / pyruvate dehydrogenase complex component X*  / reaction
 ENSMUSG00000031299 Pdha1 / P35486 / pyruvate dehydrogenase E1 alpha 1 / P08559* / pyruvate dehydrogenase E1 alpha 1 subunit*  / reaction






 

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