ENSG00000005882


Homo sapiens

Features
Gene ID: ENSG00000005882
  
Biological name :PDK2
  
Synonyms : PDK2 / pyruvate dehydrogenase kinase 2 / Q15119
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q21.33
Gene start: 50094737
Gene end: 50112152
  
Corresponding Affymetrix probe sets: 202590_s_at (Human Genome U133 Plus 2.0 Array)   213724_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000420927
Ensembl peptide - ENSP00000481915
Ensembl peptide - ENSP00000427682
Ensembl peptide - ENSP00000425615
Ensembl peptide - ENSP00000425265
Ensembl peptide - ENSP00000423310
Ensembl peptide - ENSP00000421178
Ensembl peptide - ENSP00000007708
NCBI entrez gene - 5164     See in Manteia.
OMIM - 602525
RefSeq - NM_002611
RefSeq - NM_001199898
RefSeq - NM_001199899
RefSeq Peptide - NP_001186828
RefSeq Peptide - NP_001186827
RefSeq Peptide - NP_002602
swissprot - Q15119
swissprot - D6RHG2
swissprot - D6RGV8
swissprot - D6RDN9
swissprot - D6R983
swissprot - D6RJH7
Ensembl - ENSG00000005882
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdk2aENSDARG00000020876Danio rerio
 pdk2bENSDARG00000059054Danio rerio
 ENSGALG00000045846Gallus gallus
 Pdk2ENSMUSG00000038967Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PDK1 / Q15118 / pyruvate dehydrogenase kinase 1ENSG0000015225669
PDK3 / Q15120 / pyruvate dehydrogenase kinase 3ENSG0000006799267
PDK4 / Q16654 / pyruvate dehydrogenase kinase 4ENSG0000000479964
BCKDK / O14874 / branched chain ketoacid dehydrogenase kinaseENSG0000010350727


Protein motifs (from Interpro)
Interpro ID Name
 IPR003594  Histidine kinase/HSP90-like ATPase
 IPR005467  Histidine kinase domain
 IPR018955  Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
 IPR036784  Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily
 IPR036890  Histidine kinase/HSP90-like ATPase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006006 glucose metabolic process TAS
 biological_processGO:0006111 regulation of gluconeogenesis ISS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006885 regulation of pH ISS
 biological_processGO:0008286 insulin receptor signaling pathway ISS
 biological_processGO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate ISS
 biological_processGO:0010565 regulation of cellular ketone metabolic process ISS
 biological_processGO:0010906 regulation of glucose metabolic process ISS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0031670 cellular response to nutrient ISS
 biological_processGO:0034614 cellular response to reactive oxygen species IMP
 biological_processGO:0042593 glucose homeostasis ISS
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IMP
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005759 mitochondrial matrix TAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005967 mitochondrial pyruvate dehydrogenase complex ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity TAS
 molecular_functionGO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity TAS
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IPI


Pathways (from Reactome)
Pathway description
Regulation of pyruvate dehydrogenase (PDH) complex
Signaling by Retinoic Acid


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000110435 PDHX / O00330 / pyruvate dehydrogenase complex component X  / reaction
 ENSG00000150768 DLAT / P10515 / dihydrolipoamide S-acetyltransferase  / reaction
 ENSG00000091140 DLD / P09622 / dihydrolipoamide dehydrogenase  / reaction
 ENSG00000163114 PDHA2 / P29803 / pyruvate dehydrogenase E1 alpha 2 subunit  / reaction
 ENSG00000168291 PDHB / P11177 / pyruvate dehydrogenase E1 beta subunit  / reaction
 ENSG00000131828 PDHA1 / P08559 / pyruvate dehydrogenase E1 alpha 1 subunit  / reaction






 

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