ENSG00000152256


Homo sapiens

Features
Gene ID: ENSG00000152256
  
Biological name :PDK1
  
Synonyms : PDK1 / pyruvate dehydrogenase kinase 1 / Q15118
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q31.1
Gene start: 172555373
Gene end: 172608669
  
Corresponding Affymetrix probe sets: 206686_at (Human Genome U133 Plus 2.0 Array)   226452_at (Human Genome U133 Plus 2.0 Array)   239798_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000399558
Ensembl peptide - ENSP00000399160
Ensembl peptide - ENSP00000406608
Ensembl peptide - ENSP00000413629
Ensembl peptide - ENSP00000282077
Ensembl peptide - ENSP00000376352
Ensembl peptide - ENSP00000386985
Ensembl peptide - ENSP00000388366
NCBI entrez gene - 5163     See in Manteia.
OMIM - 602524
RefSeq - XM_011511347
RefSeq - NM_001278549
RefSeq - NM_002610
RefSeq - XM_006712595
RefSeq - XM_011511343
RefSeq - XM_011511344
RefSeq - XM_011511345
RefSeq Peptide - NP_002601
RefSeq Peptide - NP_001265478
swissprot - F8WC75
swissprot - Q15118
swissprot - C9IYB4
swissprot - F8WEJ6
swissprot - C9JKT3
Ensembl - ENSG00000152256
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdk1ENSDARG00000013128Danio rerio
 PDK1ENSGALG00000013235Gallus gallus
 Pdk1ENSMUSG00000006494Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PDK2 / Q15119 / pyruvate dehydrogenase kinase 2ENSG0000000588261
PDK3 / Q15120 / pyruvate dehydrogenase kinase 3ENSG0000006799261
PDK4 / Q16654 / pyruvate dehydrogenase kinase 4ENSG0000000479958
BCKDK / O14874 / branched chain ketoacid dehydrogenase kinaseENSG0000010350726


Protein motifs (from Interpro)
Interpro ID Name
 IPR003594  Histidine kinase/HSP90-like ATPase
 IPR005467  Histidine kinase domain
 IPR018955  Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
 IPR036784  Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily
 IPR036890  Histidine kinase/HSP90-like ATPase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006006 glucose metabolic process TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress IMP
 biological_processGO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate TAS
 biological_processGO:0010906 regulation of glucose metabolic process IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0097411 hypoxia-inducible factor-1alpha signaling pathway IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005759 mitochondrial matrix TAS
 cellular_componentGO:0005967 mitochondrial pyruvate dehydrogenase complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity TAS
 molecular_functionGO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity EXP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Regulation of pyruvate dehydrogenase (PDH) complex
Signaling by Retinoic Acid


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000091140 DLD / P09622 / dihydrolipoamide dehydrogenase  / reaction
 ENSG00000150768 DLAT / P10515 / dihydrolipoamide S-acetyltransferase  / reaction
 ENSG00000110435 PDHX / O00330 / pyruvate dehydrogenase complex component X  / reaction
 ENSG00000168291 PDHB / P11177 / pyruvate dehydrogenase E1 beta subunit  / reaction
 ENSG00000131828 PDHA1 / P08559 / pyruvate dehydrogenase E1 alpha 1 subunit  / reaction
 ENSG00000163114 PDHA2 / P29803 / pyruvate dehydrogenase E1 alpha 2 subunit  / reaction






 

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