ENSG00000163114


Homo sapiens

Features
Gene ID: ENSG00000163114
  
Biological name :PDHA2
  
Synonyms : P29803 / PDHA2 / pyruvate dehydrogenase E1 alpha 2 subunit
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q22.3
Gene start: 95840019
Gene end: 95841474
  
Corresponding Affymetrix probe sets: 214518_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000295266
NCBI entrez gene - 5161     See in Manteia.
OMIM - 179061
RefSeq - NM_005390
RefSeq Peptide - NP_005381
swissprot - P29803
Ensembl - ENSG00000163114
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdha1aENSDARG00000012387Danio rerio
 pdha1bENSDARG00000010555Danio rerio
 PDHA1ENSGALG00000016430Gallus gallus
 Pdha2ENSMUSG00000047674Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PDHA1 / P08559 / pyruvate dehydrogenase E1 alpha 1 subunitENSG0000013182885
BCKDHA / P12694 / branched chain keto acid dehydrogenase E1, alpha polypeptideENSG0000024809825
AC011462.1ENSG0000025573025


Protein motifs (from Interpro)
Interpro ID Name
 IPR001017  Dehydrogenase, E1 component
 IPR017597  Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y
 IPR029061  Thiamin diphosphate-binding fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0006086 acetyl-CoA biosynthetic process from pyruvate IEA
 biological_processGO:0006090 pyruvate metabolic process IDA
 biological_processGO:0006099 tricarboxylic acid cycle IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate TAS
 biological_processGO:0034641 cellular nitrogen compound metabolic process TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005634 nucleus HDA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005739 mitochondrion IBA
 cellular_componentGO:0005759 mitochondrial matrix TAS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0045254 pyruvate dehydrogenase complex IEA
 molecular_functionGO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor IEA
 molecular_functionGO:0034604 pyruvate dehydrogenase (NAD+) activity IEA


Pathways (from Reactome)
Pathway description
Regulation of pyruvate dehydrogenase (PDH) complex
Glyoxylate metabolism and glycine degradation
Signaling by Retinoic Acid
Pyruvate metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000004799 PDK4 / Q16654 / pyruvate dehydrogenase kinase 4  / reaction
 ENSG00000005882 PDK2 / Q15119 / pyruvate dehydrogenase kinase 2  / reaction
 ENSG00000110435 PDHX / O00330 / pyruvate dehydrogenase complex component X  / complex
 ENSG00000150768 DLAT / P10515 / dihydrolipoamide S-acetyltransferase  / complex
 ENSG00000168291 PDHB / P11177 / pyruvate dehydrogenase E1 beta subunit  / complex
 ENSG00000140905 GCSH / P23434 / glycine cleavage system protein H  / reaction
 ENSG00000091140 DLD / P09622 / dihydrolipoamide dehydrogenase  / complex
 ENSG00000163114 PDHA2 / P29803 / pyruvate dehydrogenase E1 alpha 2 subunit  / complex
 ENSG00000152256 PDK1 / Q15118 / pyruvate dehydrogenase kinase 1  / reaction
 ENSG00000131828 PDHA1 / P08559 / pyruvate dehydrogenase E1 alpha 1 subunit  / complex
 ENSG00000067992 PDK3 / Q15120 / pyruvate dehydrogenase kinase 3  / reaction






 

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