ENSG00000004799


Homo sapiens

Features
Gene ID: ENSG00000004799
  
Biological name :PDK4
  
Synonyms : PDK4 / pyruvate dehydrogenase kinase 4 / Q16654
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q21.3
Gene start: 95583499
Gene end: 95596491
  
Corresponding Affymetrix probe sets: 1562321_at (Human Genome U133 Plus 2.0 Array)   205960_at (Human Genome U133 Plus 2.0 Array)   225207_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000005178
NCBI entrez gene - 5166     See in Manteia.
OMIM - 602527
RefSeq - NM_002612
RefSeq Peptide - NP_002603
swissprot - A4D1H4
swissprot - Q16654
Ensembl - ENSG00000004799
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdk4ENSDARG00000054848Danio rerio
 PDK4ENSGALG00000009700Gallus gallus
 Pdk4ENSMUSG00000019577Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PDK1 / Q15118 / pyruvate dehydrogenase kinase 1ENSG0000015225665
PDK2 / Q15119 / pyruvate dehydrogenase kinase 2ENSG0000000588263
PDK3 / Q15120 / pyruvate dehydrogenase kinase 3ENSG0000006799261
BCKDK / O14874 / branched chain ketoacid dehydrogenase kinaseENSG0000010350726


Protein motifs (from Interpro)
Interpro ID Name
 IPR003594  Histidine kinase/HSP90-like ATPase
 IPR005467  Histidine kinase domain
 IPR018955  Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
 IPR036784  Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily
 IPR036890  Histidine kinase/HSP90-like ATPase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006885 regulation of pH ISS
 biological_processGO:0008286 insulin receptor signaling pathway IMP
 biological_processGO:0009267 cellular response to starvation IDA
 biological_processGO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate IMP
 biological_processGO:0010565 regulation of cellular ketone metabolic process ISS
 biological_processGO:0010906 regulation of glucose metabolic process IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0042304 regulation of fatty acid biosynthetic process IMP
 biological_processGO:0042593 glucose homeostasis ISS
 biological_processGO:0042594 response to starvation ISS
 biological_processGO:0045124 regulation of bone resorption IEA
 biological_processGO:0046320 regulation of fatty acid oxidation ISS
 biological_processGO:0071398 cellular response to fatty acid IMP
 biological_processGO:0072593 reactive oxygen species metabolic process IMP
 biological_processGO:2000811 negative regulation of anoikis IMP
 cellular_componentGO:0005739 mitochondrion TAS
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005759 mitochondrial matrix TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity TAS
 molecular_functionGO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity TAS
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Regulation of pyruvate dehydrogenase (PDH) complex
Signaling by Retinoic Acid


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000091140 DLD / P09622 / dihydrolipoamide dehydrogenase  / reaction
 ENSG00000150768 DLAT / P10515 / dihydrolipoamide S-acetyltransferase  / reaction
 ENSG00000163114 PDHA2 / P29803 / pyruvate dehydrogenase E1 alpha 2 subunit  / reaction
 ENSG00000131828 PDHA1 / P08559 / pyruvate dehydrogenase E1 alpha 1 subunit  / reaction
 ENSG00000168291 PDHB / P11177 / pyruvate dehydrogenase E1 beta subunit  / reaction
 ENSG00000110435 PDHX / O00330 / pyruvate dehydrogenase complex component X  / reaction






 

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