ENSMUSG00000010914


Mus musculus

Features
Gene ID: ENSMUSG00000010914
  
Biological name :Pdhx
  
Synonyms : Pdhx / Pyruvate dehydrogenase protein X component, mitochondrial / Q8BKZ9
  
Possible biological names infered from orthology : O00330 / pyruvate dehydrogenase complex component X
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: E2
Gene start: 103021075
Gene end: 103073513
  
Corresponding Affymetrix probe sets: 10485429 (MoGene1.0st)   1456090_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000011058
Ensembl peptide - ENSMUSP00000119172
Ensembl peptide - ENSMUSP00000106814
NCBI entrez gene - 27402     See in Manteia.
MGI - MGI:1351627
RefSeq - NM_175094
RefSeq Peptide - NP_780303
swissprot - A2AWH8
swissprot - A2AWH7
swissprot - Q8BKZ9
Ensembl - ENSMUSG00000010914
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdhxENSDARG00000051756Danio rerio
 PDHXENSGALG00000033753Gallus gallus
 PDHXENSG00000110435Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dlat / Q8BMF4 / Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial / P10515* / dihydrolipoamide S-acetyltransferase*ENSMUSG0000000016834


Protein motifs (from Interpro)
Interpro ID Name
 IPR000089  Biotin/lipoyl attachment
 IPR001078  2-oxoacid dehydrogenase acyltransferase, catalytic domain
 IPR003016  2-oxo acid dehydrogenase, lipoyl-binding site
 IPR004167  Peripheral subunit-binding domain
 IPR011053  Single hybrid motif
 IPR036625  E3-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006086 acetyl-CoA biosynthetic process from pyruvate IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate ISO
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0045254 pyruvate dehydrogenase complex IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0034604 pyruvate dehydrogenase (NAD+) activity IEA


Pathways (from Reactome)
Pathway description
Regulation of pyruvate dehydrogenase (PDH) complex
Glyoxylate metabolism and glycine degradation
Signaling by Retinoic Acid
Pyruvate metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006494 Pdk1 / Q8BFP9 / [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial / Q15118* / pyruvate dehydrogenase kinase 1*  / reaction
 ENSMUSG00000019577 Pdk4 / O70571 / pyruvate dehydrogenase kinase, isoenzyme 4 / Q16654* / pyruvate dehydrogenase kinase 4*  / reaction
 ENSMUSG00000020664 Dld / O08749 / Dihydrolipoyl dehydrogenase, mitochondrial / P09622* / dihydrolipoamide dehydrogenase*  / complex
 ENSMUSG00000034424 Gcsh / Q91WK5 / Glycine cleavage system H protein, mitochondrial / P23434* / AC092718.3* / AC092718.8* / glycine cleavage system protein H*  / reaction
 ENSMUSG00000010914 Pdhx / Q8BKZ9 / Pyruvate dehydrogenase protein X component, mitochondrial / O00330* / pyruvate dehydrogenase complex component X*  / complex
 ENSMUSG00000000168 Dlat / Q8BMF4 / Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial / P10515* / dihydrolipoamide S-acetyltransferase*  / complex
 ENSMUSG00000021748 Pdhb / Q9D051 / Pyruvate dehydrogenase E1 component subunit beta, mitochondrial / P11177* / pyruvate dehydrogenase E1 beta subunit*  / complex
 ENSMUSG00000031299 Pdha1 / P35486 / pyruvate dehydrogenase E1 alpha 1 / P08559* / pyruvate dehydrogenase E1 alpha 1 subunit*  / complex
 ENSMUSG00000038967 Pdk2 / Q9JK42 / [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial / Q15119* / pyruvate dehydrogenase kinase 2*  / reaction
 ENSMUSG00000035232 Pdk3 / Q922H2 / pyruvate dehydrogenase kinase, isoenzyme 3 / Q15120* / pyruvate dehydrogenase kinase 3*  / reaction
 ENSMUSG00000047674 Pdha2 / P35487 / Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial / P29803* / pyruvate dehydrogenase E1 alpha 2 subunit*  / complex






 

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