Manteia

ENSMUSG00000060376

Mus musculus

Features

Gene ID:	ENSMUSG00000060376

Biological name :	Bckdha

Synonyms :	Bckdha / branched chain ketoacid dehydrogenase E1, alpha polypeptide

Possible biological names infered from orthology :	branched chain keto acid dehydrogenase E1, alpha polypeptide / P12694

Species:	Mus musculus

Chr. number:	7
Strand:	-1
Band:	A3
Gene start:	25629946
Gene end:	25658981

Corresponding Affymetrix probe sets:	10561063 (MoGene1.0st) 1416647_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000146018 Ensembl peptide - ENSMUSP00000071292 NCBI entrez gene - 12039 See in Manteia. MGI - MGI:107701 RefSeq - NM_007533 RefSeq - XM_006539486 RefSeq Peptide - NP_031559 swissprot - A0A0U1RPK5 swissprot - Q3U3J1 Ensembl - ENSMUSG00000060376

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Pdha1 / P35486 / pyruvate dehydrogenase E1 alpha 1 / P08559* / pyruvate dehydrogenase E1 alpha 1 subunit*	ENSMUSG00000031299	23
Pdha2 / P35487 / Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial / P29803* / pyruvate dehydrogenase E1 alpha 2 subunit*	ENSMUSG00000047674	22

Protein motifs (from Interpro)

Interpro ID	Name
IPR001017	Dehydrogenase, E1 component
IPR029061	Thiamin diphosphate-binding fold
IPR034616	2-oxoisovalerate dehydrogenase subunit alpha

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0008152	metabolic process	IEA
biological_process	GO:0009083	branched-chain amino acid catabolic process	IEA
biological_process	GO:0055114	oxidation-reduction process	IEA
cellular_component	GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex	IEA
molecular_function	GO:0003826	alpha-ketoacid dehydrogenase activity	IEA
molecular_function	GO:0003863	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity	IEA
molecular_function	GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	IEA

Pathways (from Reactome)

Pathway description

Glyoxylate metabolism and glycine degradation

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000000340	Dbt / P53395 / Mus musculus dihydrolipoamide branched chain transacylase E2 (Dbt), transcript variant 2, mRNA. / P11182* / dihydrolipoamide branched chain transacylase E2*	/ complex
ENSMUSG00000037826	Ppm1k / Q8BXN7 / protein phosphatase 1K (PP2C domain containing) / Q8N3J5* / protein phosphatase, Mg2+/Mn2+ dependent 1K*	/ reaction
ENSMUSG00000032263	Bckdhb / Q6P3A8 / 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial / P21953* / branched chain keto acid dehydrogenase E1 subunit beta*	/ complex
ENSMUSG00000020664	Dld / O08749 / Dihydrolipoyl dehydrogenase, mitochondrial / P09622* / dihydrolipoamide dehydrogenase*	/ complex
ENSMUSG00000060376	Bckdha / branched chain ketoacid dehydrogenase E1, alpha polypeptide / P12694* / branched chain keto acid dehydrogenase E1, alpha polypeptide*	/ complex
ENSMUSG00000034424	Gcsh / Q91WK5 / Glycine cleavage system H protein, mitochondrial / P23434* / AC092718.3* / AC092718.8* / glycine cleavage system protein H*	/ reaction
ENSMUSG00000030802	Bckdk / O55028 / [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial / O14874* / branched chain ketoacid dehydrogenase kinase*	/ reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr