ENSMUSG00000037826


Mus musculus

Features
Gene ID: ENSMUSG00000037826
  
Biological name :Ppm1k
  
Synonyms : Ppm1k / protein phosphatase 1K (PP2C domain containing) / Q8BXN7
  
Possible biological names infered from orthology : protein phosphatase, Mg2+/Mn2+ dependent 1K / Q8N3J5
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: B3
Gene start: 57506502
Gene end: 57535468
  
Corresponding Affymetrix probe sets: 10545001 (MoGene1.0st)   1441988_at (Mouse Genome 430 2.0 Array)   1452973_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041395
Ensembl peptide - ENSMUSP00000145312
NCBI entrez gene - 243382     See in Manteia.
MGI - MGI:2442111
RefSeq - NM_175523
RefSeq Peptide - NP_780732
swissprot - B9EHW0
swissprot - A0A0N4SVZ5
swissprot - Q8BXN7
Ensembl - ENSMUSG00000037826
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppm1kENSDARG00000010655Danio rerio
 si:ch211-149b19.3ENSDARG00000076011Danio rerio
 PPM1KENSGALG00000011266Gallus gallus
 PPM1KENSG00000163644Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ppm1f / Q8CGA0 / Protein phosphatase 1F / P49593* / protein phosphatase, Mg2+/Mn2+ dependent 1F*ENSMUSG0000002618128
Ppm1l / Q8BHN0 / Protein phosphatase 1L / Q5SGD2* / protein phosphatase, Mg2+/Mn2+ dependent 1L*ENSMUSG0000002778427
Ppm1e / Q80TL0 / Protein phosphatase 1E / Q8WY54* / protein phosphatase, Mg2+/Mn2+ dependent 1E*ENSMUSG0000004644227
Ilkap / Q8R0F6 / Mus musculus integrin-linked kinase-associated serine/threonine phosphatase 2C (Ilkap), transcript variant 2, mRNA. / Q9H0C8* / ILK associated serine/threonine phosphatase*ENSMUSG0000002630923


Protein motifs (from Interpro)
Interpro ID Name
 IPR000222  PPM-type phosphatase, divalent cation binding
 IPR001932  PPM-type phosphatase domain
 IPR015655  Protein phosphatase 2C family
 IPR036457  PPM-type phosphatase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005759 mitochondrial matrix IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0043169 cation binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Branched-chain amino acid catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Mark2tm1Hpw/Mark2tm1Hpw
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000340 Dbt / P53395 / Mus musculus dihydrolipoamide branched chain transacylase E2 (Dbt), transcript variant 2, mRNA. / P11182* / dihydrolipoamide branched chain transacylase E2*  / reaction
 ENSMUSG00000032263 Bckdhb / Q6P3A8 / 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial / P21953* / branched chain keto acid dehydrogenase E1 subunit beta*  / reaction
 ENSMUSG00000020664 Dld / O08749 / Dihydrolipoyl dehydrogenase, mitochondrial / P09622* / dihydrolipoamide dehydrogenase*  / reaction
 ENSMUSG00000060376 Bckdha / branched chain ketoacid dehydrogenase E1, alpha polypeptide / P12694* / branched chain keto acid dehydrogenase E1, alpha polypeptide*  / reaction






 

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