ENSMUSG00000032263


Mus musculus

Features
Gene ID: ENSMUSG00000032263
  
Biological name :Bckdhb
  
Synonyms : 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial / Bckdhb / Q6P3A8
  
Possible biological names infered from orthology : branched chain keto acid dehydrogenase E1 subunit beta / P21953
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: E2
Gene start: 83925145
Gene end: 84124240
  
Corresponding Affymetrix probe sets: 10587534 (MoGene1.0st)   1427153_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034801
Ensembl peptide - ENSMUSP00000139684
Ensembl peptide - ENSMUSP00000140598
NCBI entrez gene - 12040     See in Manteia.
MGI - MGI:88137
RefSeq - XM_017313114
RefSeq - NM_001305935
RefSeq - NM_199195
RefSeq - XM_006510786
RefSeq Peptide - NP_001292864
RefSeq Peptide - NP_954665
swissprot - Q6P3A8
Ensembl - ENSMUSG00000032263
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bckdhbENSDARG00000014676Danio rerio
 BCKDHBENSGALG00000040702Gallus gallus
 BCKDHBENSG00000083123Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pdhb / Q9D051 / Pyruvate dehydrogenase E1 component subunit beta, mitochondrial / P11177* / pyruvate dehydrogenase E1 beta subunit*ENSMUSG0000002174826


Protein motifs (from Interpro)
Interpro ID Name
 IPR005475  Transketolase-like, pyrimidine-binding domain
 IPR009014  Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II
 IPR029061  Thiamin diphosphate-binding fold
 IPR033248  Transketolase, C-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009063 cellular amino acid catabolic process TAS
 biological_processGO:0009083 branched-chain amino acid catabolic process ISS
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion ISS
 cellular_componentGO:0005743 mitochondrial inner membrane TAS
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex ISO
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003826 alpha-ketoacid dehydrogenase activity IDA
 molecular_functionGO:0003863 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Glyoxylate metabolism and glycine degradation
Branched-chain amino acid catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000340 Dbt / P53395 / Mus musculus dihydrolipoamide branched chain transacylase E2 (Dbt), transcript variant 2, mRNA. / P11182* / dihydrolipoamide branched chain transacylase E2*  / complex
 ENSMUSG00000037826 Ppm1k / Q8BXN7 / protein phosphatase 1K (PP2C domain containing) / Q8N3J5* / protein phosphatase, Mg2+/Mn2+ dependent 1K*  / reaction
 ENSMUSG00000020664 Dld / O08749 / Dihydrolipoyl dehydrogenase, mitochondrial / P09622* / dihydrolipoamide dehydrogenase*  / complex
 ENSMUSG00000032263 Bckdhb / Q6P3A8 / 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial / P21953* / branched chain keto acid dehydrogenase E1 subunit beta*  / complex
 ENSMUSG00000060376 Bckdha / branched chain ketoacid dehydrogenase E1, alpha polypeptide / P12694* / branched chain keto acid dehydrogenase E1, alpha polypeptide*  / complex
 ENSMUSG00000034424 Gcsh / Q91WK5 / Glycine cleavage system H protein, mitochondrial / P23434* / AC092718.3* / AC092718.8* / glycine cleavage system protein H*  / reaction
 ENSMUSG00000030802 Bckdk / O55028 / [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial / O14874* / branched chain ketoacid dehydrogenase kinase*  / reaction






 

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