ENSMUSG00000000340


Mus musculus

Features
Gene ID: ENSMUSG00000000340
  
Biological name :Dbt
  
Synonyms : Dbt / Mus musculus dihydrolipoamide branched chain transacylase E2 (Dbt), transcript variant 2, mRNA. / P53395
  
Possible biological names infered from orthology : dihydrolipoamide branched chain transacylase E2 / P11182
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: G1
Gene start: 116513070
Gene end: 116549981
  
Corresponding Affymetrix probe sets: 10495549 (MoGene1.0st)   1449118_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143713
Ensembl peptide - ENSMUSP00000000349
Ensembl peptide - ENSMUSP00000143696
NCBI entrez gene - 13171     See in Manteia.
MGI - MGI:105386
RefSeq - XM_006500977
RefSeq - NM_001357344
RefSeq - NM_010022
RefSeq - XM_006500976
RefSeq Peptide - NP_001344273
RefSeq Peptide - NP_034152
swissprot - A0A0G2JGV4
swissprot - P53395
swissprot - A0A0G2JGU0
Ensembl - ENSMUSG00000000340
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dbtENSDARG00000101561Danio rerio
 DBTENSGALG00000005280Gallus gallus
 DBTENSG00000137992Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dlst / Q9D2G2 / Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial / P36957* / dihydrolipoamide S-succinyltransferase*ENSMUSG0000000478923


Protein motifs (from Interpro)
Interpro ID Name
 IPR000089  Biotin/lipoyl attachment
 IPR001078  2-oxoacid dehydrogenase acyltransferase, catalytic domain
 IPR003016  2-oxo acid dehydrogenase, lipoyl-binding site
 IPR004167  Peripheral subunit-binding domain
 IPR011053  Single hybrid motif
 IPR015761  Branched-chain alpha-ketoacid dehydrogenase complex component E2
 IPR036625  E3-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008152 metabolic process IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0042645 mitochondrial nucleoid IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0043754 dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity IEA


Pathways (from Reactome)
Pathway description
Glyoxylate metabolism and glycine degradation
Branched-chain amino acid catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Eloatm1Aso/Eloatm1Aso,Trp53tm1Sia/Trp53tm1Sia
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Eloatm1Aso/Eloatm1Aso,Trp53tm1Sia/Trp53tm1Sia
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

Allelic Composition: Dbttm1Geh/Dbttm1Geh,Tg(tetO-DBT)525AGeh/0,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB * NMRI

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Eloatm1Aso/Eloatm1Aso,Trp53tm1Sia/Trp53tm1Sia
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

Allelic Composition: Dbttm1Geh/Dbttm1Geh,Tg(tetO-DBT)525AGeh/0,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB * NMRI

 MP:0003311 aminoaciduria "excretion of amino acids in the urine, especially in excessive amounts" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:66560]
Show

Allelic Composition: Eloatm1Aso/Eloatm1Aso,Trp53tm1Sia/Trp53tm1Sia
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Eloatm1Aso/Eloatm1Aso,Trp53tm1Sia/Trp53tm1Sia
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Eloatm1Aso/Eloatm1Aso,Trp53tm1Sia/Trp53tm1Sia
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
Show

Allelic Composition: Eloatm1Aso/Eloatm1Aso,Trp53tm1Sia/Trp53tm1Sia
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

Allelic Composition: Dbttm1Geh/Dbttm1Geh,Tg(tetO-DBT)A1Geh/0,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB * NMRI

Allelic Composition: Dbttm1Geh/Dbttm1Geh,Tg(tetO-DBT)525AGeh/0,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB * NMRI

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Eloatm1Aso/Eloatm1Aso,Trp53tm1Sia/Trp53tm1Sia
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dbttm1Geh/Dbttm1Geh,Tg(tetO-DBT)A1Geh/0,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB * NMRI

Allelic Composition: Dbttm1Geh/Dbttm1Geh,Tg(tetO-DBT)525AGeh/0,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB * NMRI

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Eloatm1Aso/Eloatm1Aso,Trp53tm1Sia/Trp53tm1Sia
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000034424 Gcsh / Q91WK5 / Glycine cleavage system H protein, mitochondrial / P23434* / AC092718.3* / AC092718.8* / glycine cleavage system protein H*  / reaction
 ENSMUSG00000000340 Dbt / P53395 / Mus musculus dihydrolipoamide branched chain transacylase E2 (Dbt), transcript variant 2, mRNA. / P11182* / dihydrolipoamide branched chain transacylase E2*  / complex
 ENSMUSG00000032263 Bckdhb / Q6P3A8 / 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial / P21953* / branched chain keto acid dehydrogenase E1 subunit beta*  / complex
 ENSMUSG00000020664 Dld / O08749 / Dihydrolipoyl dehydrogenase, mitochondrial / P09622* / dihydrolipoamide dehydrogenase*  / complex
 ENSMUSG00000060376 Bckdha / branched chain ketoacid dehydrogenase E1, alpha polypeptide / P12694* / branched chain keto acid dehydrogenase E1, alpha polypeptide*  / complex
 ENSMUSG00000037826 Ppm1k / Q8BXN7 / protein phosphatase 1K (PP2C domain containing) / Q8N3J5* / protein phosphatase, Mg2+/Mn2+ dependent 1K*  / reaction
 ENSMUSG00000030802 Bckdk / O55028 / [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial / O14874* / branched chain ketoacid dehydrogenase kinase*  / reaction






 

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