ENSMUSG00000027784


Mus musculus

Features
Gene ID: ENSMUSG00000027784
  
Biological name :Ppm1l
  
Synonyms : Ppm1l / Protein phosphatase 1L / Q8BHN0
  
Possible biological names infered from orthology : protein phosphatase, Mg2+/Mn2+ dependent 1L / Q5SGD2
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: E1
Gene start: 69316861
Gene end: 69560802
  
Corresponding Affymetrix probe sets: 10492590 (MoGene1.0st)   1435699_at (Mouse Genome 430 2.0 Array)   1435787_at (Mouse Genome 430 2.0 Array)   1438012_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029355
NCBI entrez gene - 242083     See in Manteia.
MGI - MGI:2139740
RefSeq - NM_178726
RefSeq Peptide - NP_848841
swissprot - Q8BHN0
Ensembl - ENSMUSG00000027784
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppm1laENSDARG00000063218Danio rerio
 ppm1lbENSDARG00000089641Danio rerio
 PPM1LENSGALG00000009537Gallus gallus
 PPM1LENSG00000163590Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ppm1k / Q8BXN7 / protein phosphatase 1K (PP2C domain containing) / Q8N3J5* / protein phosphatase, Mg2+/Mn2+ dependent 1K*ENSMUSG0000003782628
Ilkap / Q8R0F6 / Mus musculus integrin-linked kinase-associated serine/threonine phosphatase 2C (Ilkap), transcript variant 2, mRNA. / Q9H0C8* / ILK associated serine/threonine phosphatase*ENSMUSG0000002630926
Ppm1e / Q80TL0 / Protein phosphatase 1E / Q8WY54* / protein phosphatase, Mg2+/Mn2+ dependent 1E*ENSMUSG0000004644226
Ppm1f / Q8CGA0 / Protein phosphatase 1F / P49593* / protein phosphatase, Mg2+/Mn2+ dependent 1F*ENSMUSG0000002618125


Protein motifs (from Interpro)
Interpro ID Name
 IPR000222  PPM-type phosphatase, divalent cation binding
 IPR001932  PPM-type phosphatase domain
 IPR015655  Protein phosphatase 2C family
 IPR036457  PPM-type phosphatase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IPI
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0043169 cation binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000781 reduced size of corpus callosum "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Gt(ROSA)26Sortm12.1Sia/Gt(ROSA)26Sor+,Haus6tm1.2Sdwb/Haus6tm1.2Sdwb
Genetic Background: B6.Cg-Haus6tm1.2Sdwb Gt(ROSA)26Sortm12.1Sia

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Gt(ROSA)26Sortm12.1Sia/Gt(ROSA)26Sor+,Haus6tm1.2Sdwb/Haus6tm1.2Sdwb
Genetic Background: B6.Cg-Haus6tm1.2Sdwb Gt(ROSA)26Sortm12.1Sia

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Il10rbtm1Agt/Il10rbtm1Agt,Tg(Cd4-TGFBR2)16Flv/?
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm12.1Sia/Gt(ROSA)26Sor+,Haus6tm1.2Sdwb/Haus6tm1.2Sdwb
Genetic Background: B6.Cg-Haus6tm1.2Sdwb Gt(ROSA)26Sortm12.1Sia

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm12.1Sia/Gt(ROSA)26Sor+,Haus6tm1.2Sdwb/Haus6tm1.2Sdwb
Genetic Background: B6.Cg-Haus6tm1.2Sdwb Gt(ROSA)26Sortm12.1Sia

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
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Allelic Composition: Gt(ROSA)26Sortm12.1Sia/Gt(ROSA)26Sor+,Haus6tm1.2Sdwb/Haus6tm1.2Sdwb
Genetic Background: B6.Cg-Haus6tm1.2Sdwb Gt(ROSA)26Sortm12.1Sia

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il10rbtm1Agt/Il10rbtm1Agt,Tg(Cd4-TGFBR2)16Flv/?
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il10rbtm1Agt/Il10rbtm1Agt,Tg(Cd4-TGFBR2)16Flv/?
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6

 MP:0004102 abnormal dorsal striatum morphology "any structural abnormality of the regions of the caudate nucleus and the putamen that lie dorsal to the anterior commissure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm12.1Sia/Gt(ROSA)26Sor+,Haus6tm1.2Sdwb/Haus6tm1.2Sdwb
Genetic Background: B6.Cg-Haus6tm1.2Sdwb Gt(ROSA)26Sortm12.1Sia

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il10rbtm1Agt/Il10rbtm1Agt,Tg(Cd4-TGFBR2)16Flv/?
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Il10rbtm1Agt/Il10rbtm1Agt,Tg(Cd4-TGFBR2)16Flv/?
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6

 MP:0008225 abnormal anterior commissure morphology "any structural anomaly of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Gt(ROSA)26Sortm12.1Sia/Gt(ROSA)26Sor+,Haus6tm1.2Sdwb/Haus6tm1.2Sdwb
Genetic Background: B6.Cg-Haus6tm1.2Sdwb Gt(ROSA)26Sortm12.1Sia

 MP:0008226 decreased anterior commissure size "reduced size of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Gt(ROSA)26Sortm12.1Sia/Gt(ROSA)26Sor+,Haus6tm1.2Sdwb/Haus6tm1.2Sdwb
Genetic Background: B6.Cg-Haus6tm1.2Sdwb Gt(ROSA)26Sortm12.1Sia

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm12.1Sia/Gt(ROSA)26Sor+,Haus6tm1.2Sdwb/Haus6tm1.2Sdwb
Genetic Background: B6.Cg-Haus6tm1.2Sdwb Gt(ROSA)26Sortm12.1Sia

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm12.1Sia/Gt(ROSA)26Sor+,Haus6tm1.2Sdwb/Haus6tm1.2Sdwb
Genetic Background: B6.Cg-Haus6tm1.2Sdwb Gt(ROSA)26Sortm12.1Sia

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il10rbtm1Agt/Il10rbtm1Agt,Tg(Cd4-TGFBR2)16Flv/?
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm12.1Sia/Gt(ROSA)26Sor+,Haus6tm1.2Sdwb/Haus6tm1.2Sdwb
Genetic Background: B6.Cg-Haus6tm1.2Sdwb Gt(ROSA)26Sortm12.1Sia

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm12.1Sia/Gt(ROSA)26Sor+,Haus6tm1.2Sdwb/Haus6tm1.2Sdwb
Genetic Background: B6.Cg-Haus6tm1.2Sdwb Gt(ROSA)26Sortm12.1Sia

 MP:0011731 decreased myelin sheath thickness "decrease in the depth of the insulating envelope that surrounds nerve fibers or axons" [MGI:smb]
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Allelic Composition: Gt(ROSA)26Sortm12.1Sia/Gt(ROSA)26Sor+,Haus6tm1.2Sdwb/Haus6tm1.2Sdwb
Genetic Background: B6.Cg-Haus6tm1.2Sdwb Gt(ROSA)26Sortm12.1Sia

 MP:0012468 decreased striatum area "reduced size of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [ISBN:0838580343, MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm12.1Sia/Gt(ROSA)26Sor+,Haus6tm1.2Sdwb/Haus6tm1.2Sdwb
Genetic Background: B6.Cg-Haus6tm1.2Sdwb Gt(ROSA)26Sortm12.1Sia

 MP:0013438 dysmyelination "reduced amount of myelin present in the form of a myelin sheath surrounding an axon due to defects in the synthesis and formation of myelin" [MGI:csmith]
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Allelic Composition: Gt(ROSA)26Sortm12.1Sia/Gt(ROSA)26Sor+,Haus6tm1.2Sdwb/Haus6tm1.2Sdwb
Genetic Background: B6.Cg-Haus6tm1.2Sdwb Gt(ROSA)26Sortm12.1Sia

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024091 Vapa / Q9WV55 / vesicle-associated membrane protein, associated protein A / Q9P0L0* / VAMP associated protein A*  / complex
 ENSMUSG00000054455 Vapb / vesicle-associated membrane protein, associated protein B and C / O95292* / VAMP associated protein B and C*  / complex
 ENSMUSG00000021669 Q9EQG9 / Col4a3bp / Collagen type IV alpha-3-binding protein / Q9Y5P4*  / reaction / complex






 

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