ENSMUSG00000054455


Mus musculus

Features
Gene ID: ENSMUSG00000054455
  
Biological name :Vapb
  
Synonyms : Vapb / vesicle-associated membrane protein, associated protein B and C
  
Possible biological names infered from orthology : O95292 / VAMP associated protein B and C
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H4
Gene start: 173737511
Gene end: 173784336
  
Corresponding Affymetrix probe sets: 10479077 (MoGene1.0st)   1423152_at (Mouse Genome 430 2.0 Array)   1436079_s_at (Mouse Genome 430 2.0 Array)   1458501_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000064699
NCBI entrez gene - 56491     See in Manteia.
MGI - MGI:1928744
RefSeq - NM_019806
RefSeq Peptide - NP_062780
swissprot - Q8BH80
Ensembl - ENSMUSG00000054455
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vapbENSDARG00000070435Danio rerio
 VAPBENSGALG00000007549Gallus gallus
 VAPBENSG00000124164Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vapa / Q9WV55 / vesicle-associated membrane protein, associated protein A / Q9P0L0* / VAMP associated protein A*ENSMUSG0000002409160


Protein motifs (from Interpro)
Interpro ID Name
 IPR000535  Major sperm protein (MSP) domain
 IPR008962  PapD-like superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016763  Vesicle-associated membrane-protein-associated protein
 IPR030226  Vesicle-associated membrane protein-associated protein B


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport IEA
 biological_processGO:0006987 obsolete activation of signaling protein activity involved in unfolded protein response IEA
 biological_processGO:0007029 endoplasmic reticulum organization IEA
 biological_processGO:0019048 modulation by virus of host morphology or physiology IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response ISS
 biological_processGO:0045070 positive regulation of viral genome replication IEA
 biological_processGO:0090114 COPII-coated vesicle budding IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISS
 cellular_componentGO:0005794 Golgi apparatus ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0033149 FFAT motif binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0048487 beta-tubulin binding IEA


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm5(H1/tetO-RNAi:Ezh2)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * FVB

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
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Allelic Composition: Vapbtm1.1Tsud/Vapbtm1.1Tsud
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Vapbtm1.1Tsud/Vapb+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm5(H1/tetO-RNAi:Ezh2)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * FVB

Allelic Composition: Vapbtm1.1Tsud/Vapbtm1.1Tsud
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Vapbtm1.1Tsud/Vapb+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003858 enhanced coordination "improved ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Arrdc3Gt(CSE513)Byg/Arrdc3+
Genetic Background: B6.129P2-Arrdc3Gt(CSE513)Byg

 MP:0004144 hypotonia "decreased muscle tension resulting in limpness of the muscles in the resting state, not to be confused with weakness" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm5(H1/tetO-RNAi:Ezh2)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * FVB

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Vapbtm1.1Tsud/Vapbtm1.1Tsud
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Vapbtm1.1Tsud/Vapb+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008571 abnormal synaptic bouton morphology "any structural anomaly of the knoblike enlargements along the course of axons, or more commonly at the distal terminations of axons which are specialized for the release of neurotransmitters" [MESH:A08.663.542.145.750]
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Allelic Composition: Vapbtm1.1Tsud/Vapbtm1.1Tsud
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Vapbtm1.1Tsud/Vapb+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vapbtm1.1Tsud/Vapbtm1.1Tsud
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009413 skeletal muscle fiber atrophy "a wasting of skeletal muscle fibers resulting in a derangement of the skeletal muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vapbtm1.1Tsud/Vapbtm1.1Tsud
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011975 neuronal cytoplasmic inclusions "presence of aggregates of protein within the cytoplasm of neurons; hallmark of neurodegenerative disorders" [MGI:mnk]
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Allelic Composition: Vapbtm1.1Tsud/Vapbtm1.1Tsud
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Vapbtm1.1Tsud/Vapb+
Genetic Background: involves: 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027784 Ppm1l / Q8BHN0 / Protein phosphatase 1L / Q5SGD2* / protein phosphatase, Mg2+/Mn2+ dependent 1L*  / complex
 ENSMUSG00000021669 Q9EQG9 / Col4a3bp / Collagen type IV alpha-3-binding protein / Q9Y5P4*  / reaction / complex






 

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