ENSG00000163590


Homo sapiens

Features
Gene ID: ENSG00000163590
  
Biological name :PPM1L
  
Synonyms : PPM1L / protein phosphatase, Mg2+/Mn2+ dependent 1L / Q5SGD2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q25.33
Gene start: 160755602
Gene end: 161078907
  
Corresponding Affymetrix probe sets: 228108_at (Human Genome U133 Plus 2.0 Array)   228457_at (Human Genome U133 Plus 2.0 Array)   229506_at (Human Genome U133 Plus 2.0 Array)   236339_at (Human Genome U133 Plus 2.0 Array)   239488_at (Human Genome U133 Plus 2.0 Array)   239855_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000295839
Ensembl peptide - ENSP00000417659
Ensembl peptide - ENSP00000420354
Ensembl peptide - ENSP00000420746
NCBI entrez gene - 151742     See in Manteia.
OMIM - 611931
RefSeq - NM_001317911
RefSeq - NM_001317912
RefSeq - NM_139245
RefSeq Peptide - NP_001304840
RefSeq Peptide - NP_001304841
RefSeq Peptide - NP_640338
swissprot - Q5SGD2
Ensembl - ENSG00000163590
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppm1laENSDARG00000063218Danio rerio
 ppm1lbENSDARG00000089641Danio rerio
 PPM1LENSGALG00000009537Gallus gallus
 Ppm1lENSMUSG00000027784Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PPM1K / Q8N3J5 / protein phosphatase, Mg2+/Mn2+ dependent 1KENSG0000016364429
ILKAP / Q9H0C8 / ILK associated serine/threonine phosphataseENSG0000013232326
PPM1F / P49593 / protein phosphatase, Mg2+/Mn2+ dependent 1FENSG0000010003426
PPM1E / Q8WY54 / protein phosphatase, Mg2+/Mn2+ dependent 1EENSG0000017517526


Protein motifs (from Interpro)
Interpro ID Name
 IPR000222  PPM-type phosphatase, divalent cation binding
 IPR001932  PPM-type phosphatase domain
 IPR015655  Protein phosphatase 2C family
 IPR036457  PPM-type phosphatase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IEA
 biological_processGO:0030148 sphingolipid biosynthetic process TAS
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0043169 cation binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000113163 Q9Y5P4 / COL4A3BP / collagen type IV alpha 3 binding protein  / complex / reaction
 ENSG00000101558 VAPA / Q9P0L0 / VAMP associated protein A  / complex
 ENSG00000124164 VAPB / O95292 / VAMP associated protein B and C  / complex






 

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