ENSG00000175175


Homo sapiens

Features
Gene ID: ENSG00000175175
  
Biological name :PPM1E
  
Synonyms : PPM1E / protein phosphatase, Mg2+/Mn2+ dependent 1E / Q8WY54
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q22
Gene start: 58755869
Gene end: 58985176
  
Corresponding Affymetrix probe sets: 205938_at (Human Genome U133 Plus 2.0 Array)   236302_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000312411
NCBI entrez gene - 22843     See in Manteia.
RefSeq - XM_017024359
RefSeq - NM_014906
RefSeq - XM_005257169
RefSeq - XM_011524534
RefSeq Peptide - NP_055721
swissprot - Q8WY54
Ensembl - ENSG00000175175
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppm1eENSDARG00000026499Danio rerio
 PPM1EENSGALG00000005061Gallus gallus
 Ppm1eENSMUSG00000046442Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PPM1F / P49593 / protein phosphatase, Mg2+/Mn2+ dependent 1FENSG0000010003428
PPM1K / Q8N3J5 / protein phosphatase, Mg2+/Mn2+ dependent 1KENSG0000016364414
ILKAP / Q9H0C8 / ILK associated serine/threonine phosphataseENSG0000013232314
PPM1L / Q5SGD2 / protein phosphatase, Mg2+/Mn2+ dependent 1LENSG0000016359012


Protein motifs (from Interpro)
Interpro ID Name
 IPR000222  PPM-type phosphatase, divalent cation binding
 IPR001932  PPM-type phosphatase domain
 IPR015655  Protein phosphatase 2C family
 IPR036457  PPM-type phosphatase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IDA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0035690 cellular response to drug IDA
 biological_processGO:0035970 peptidyl-threonine dephosphorylation IDA
 biological_processGO:0051496 positive regulation of stress fiber assembly IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0043169 cation binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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