ENSMUSG00000032607


Mus musculus

Features
Gene ID: ENSMUSG00000032607
  
Biological name :Amt
  
Synonyms : Aminomethyltransferase, mitochondrial / Amt / Q8CFA2
  
Possible biological names infered from orthology : aminomethyltransferase / P48728
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F1
Gene start: 108296853
Gene end: 108302302
  
Corresponding Affymetrix probe sets: 10588883 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000035230
NCBI entrez gene - 434437     See in Manteia.
MGI - MGI:3646700
RefSeq - NM_001013814
RefSeq Peptide - NP_001013836
swissprot - A2RSW6
swissprot - Q8CFA2
Ensembl - ENSMUSG00000032607
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 amtENSDARG00000010862Danio rerio
 AMTENSGALG00000025844Gallus gallus
 AMTENSG00000145020Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dmgdh / Q9DBT9 / Dimethylglycine dehydrogenase, mitochondrial / Q9UI17* / dimethylglycine dehydrogenase*ENSMUSG0000004210225
Pdpr / Q7TSQ8 / Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial / Q8NCN5* / pyruvate dehydrogenase phosphatase regulatory subunit*ENSMUSG0000003362423
Sardh / Q99LB7 / sarcosine dehydrogenase / Q9UL12*ENSMUSG0000000961422


Protein motifs (from Interpro)
Interpro ID Name
 IPR006222  Aminomethyltransferase, folate-binding domain
 IPR006223  Glycine cleavage system T protein
 IPR013977  Glycine cleavage T-protein, C-terminal barrel domain
 IPR028896  Aminomethyltransferase-like
 IPR029043  Glycine cleavage T-protein/YgfZ, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006546 glycine catabolic process IEA
 biological_processGO:0019464 glycine decarboxylation via glycine cleavage system ISO
 biological_processGO:0032259 methylation IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 molecular_functionGO:0004047 aminomethyltransferase activity ISO
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008483 transaminase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Glycine degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Cfc1b2b970Clo/Cfc1b2b970Clo
Genetic Background: C57BL/6J-Cfc1b2b970Clo

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
Show

Allelic Composition: Cfc1b2b970Clo/Cfc1b2b970Clo
Genetic Background: C57BL/6J-Cfc1b2b970Clo

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cfc1b2b970Clo/Cfc1b2b970Clo
Genetic Background: C57BL/6J-Cfc1b2b970Clo

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cfc1b2b970Clo/Cfc1b2b970Clo
Genetic Background: C57BL/6J-Cfc1b2b970Clo

 MP:0008784 craniorachischisis "congenital fissure of the skull and vertebral column" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cfc1b2b970Clo/Cfc1b2b970Clo
Genetic Background: C57BL/6J-Cfc1b2b970Clo

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000034424 Gcsh / Q91WK5 / Glycine cleavage system H protein, mitochondrial / P23434* / AC092718.3* / AC092718.8* / glycine cleavage system protein H*  / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr