ENSMUSG00000042102


Mus musculus

Features
Gene ID: ENSMUSG00000042102
  
Biological name :Dmgdh
  
Synonyms : Dimethylglycine dehydrogenase, mitochondrial / Dmgdh / Q9DBT9
  
Possible biological names infered from orthology : dimethylglycine dehydrogenase / Q9UI17
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: C3
Gene start: 93674433
Gene end: 93752833
  
Corresponding Affymetrix probe sets: 10406646 (MoGene1.0st)   1452311_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039663
NCBI entrez gene - 74129     See in Manteia.
MGI - MGI:1921379
RefSeq - NM_028772
RefSeq Peptide - NP_083048
swissprot - Q9DBT9
Ensembl - ENSMUSG00000042102
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dmgdhENSDARG00000025703Danio rerio
 DMGDHENSGALG00000004491Gallus gallus
 DMGDHENSG00000132837Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sardh / Q99LB7 / sarcosine dehydrogenase / Q9UL12*ENSMUSG0000000961431
Pdpr / Q7TSQ8 / Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial / Q8NCN5* / pyruvate dehydrogenase phosphatase regulatory subunit*ENSMUSG0000003362430
Amt / Q8CFA2 / Aminomethyltransferase, mitochondrial / P48728* / aminomethyltransferase*ENSMUSG0000003260712


Protein motifs (from Interpro)
Interpro ID Name
 IPR006076  FAD dependent oxidoreductase
 IPR006222  Aminomethyltransferase, folate-binding domain
 IPR013977  Glycine cleavage T-protein, C-terminal barrel domain
 IPR029043  Glycine cleavage T-protein/YgfZ, C-terminal
 IPR032503  FAD dependent oxidoreductase, central domain
 IPR036188  FAD/NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006579 amino-acid betaine catabolic process IEA
 biological_processGO:0042426 choline catabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005759 mitochondrial matrix IBA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0047865 dimethylglycine dehydrogenase activity ISO


Pathways (from Reactome)
Pathway description
Choline catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005478 decreased circulating thyroxine level "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+
Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics

 MP:0013026 decreased Ly6C low monocyte number "decrease in the number of monocytes that express low levels of Ly6C and low MHC class II that represent a subset of patrolling monocytes" [MGI:Annie_Speak]
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Allelic Composition: Xbp1tm1a(EUCOMM)Wtsi/Xbp1+
Genetic Background: C57BL/6N-Xbp1tm1a(EUCOMM)Wtsi/Ics

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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