ENSMUSG00000029199


Mus musculus

Features
Gene ID: ENSMUSG00000029199
  
Biological name :Lias
  
Synonyms : Lias / Lipoyl synthase, mitochondrial / Q99M04
  
Possible biological names infered from orthology : lipoic acid synthetase / O43766
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: C3.1
Gene start: 65391497
Gene end: 65410693
  
Corresponding Affymetrix probe sets: 10522134 (MoGene1.0st)   1418700_at (Mouse Genome 430 2.0 Array)   1431935_at (Mouse Genome 430 2.0 Array)   1447027_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113228
Ensembl peptide - ENSMUSP00000143152
Ensembl peptide - ENSMUSP00000031101
NCBI entrez gene - 79464     See in Manteia.
MGI - MGI:1934604
RefSeq - NM_024471
RefSeq - NM_001310612
RefSeq Peptide - NP_001297541
RefSeq Peptide - NP_077791
swissprot - Q99M04
swissprot - A0A0M3HEP3
swissprot - A0A0G2JFF7
Ensembl - ENSMUSG00000029199
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 liasENSDARG00000022845Danio rerio
 ENSGALG00000014312Gallus gallus
 ENSGALG00000031933Gallus gallus
 LIASENSG00000121897Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003698  Lipoyl synthase
 IPR006638  Elp3/MiaB/NifB
 IPR007197  Radical SAM
 IPR013785  Aldolase-type TIM barrel
 IPR031691  Lipoyl synthase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0006954 inflammatory response IMP
 biological_processGO:0006979 response to oxidative stress IMP
 biological_processGO:0009107 lipoate biosynthetic process IGI
 biological_processGO:0009249 protein lipoylation IBA
 biological_processGO:0032496 response to lipopolysaccharide IMP
 cellular_componentGO:0005739 mitochondrion IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016783 sulfurtransferase activity IEA
 molecular_functionGO:0016992 lipoate synthase activity IGI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051539 4 iron, 4 sulfur cluster binding IEA


Pathways (from Reactome)
Pathway description
Glyoxylate metabolism and glycine degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cyfip1Gt(XG769)Byg/Cyfip1Gt(XG769)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000784 forebrain hypoplasia "reduced cell number in the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cyfip1Gt(XG769)Byg/Cyfip1Gt(XG769)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000785 telencephalon hypoplasia "reduced cell number in cerebral cortex and basal ganglia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Cyfip1Gt(XG769)Byg/Cyfip1Gt(XG769)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Ift172wim/Ift172wim
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Cyfip1Gt(XG769)Byg/Cyfip1Gt(XG769)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Tmem79ma/Tmem79ma
Genetic Background: involves: C57BL/Gr * CBA/CaGr

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Tmem79ma/Tmem79ma
Genetic Background: involves: C57BL/Gr * CBA/CaGr

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Cyfip1Gt(XG769)Byg/Cyfip1Gt(XG769)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cyfip1Gt(XG769)Byg/Cyfip1Gt(XG769)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Liasnehe/Liastm1Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0004387 abnormal prechordal plate morphology "any structural anomaly of the horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann s organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]
Show

Allelic Composition: Cyfip1Gt(XG769)Byg/Cyfip1Gt(XG769)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cyfip1Gt(XG769)Byg/Cyfip1Gt(XG769)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tmem79ma/Tmem79ma
Genetic Background: involves: C57BL/Gr * CBA/CaGr

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Tmem79ma/Tmem79ma
Genetic Background: involves: C57BL/Gr * CBA/CaGr

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Ift172wim/Ift172wim
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Liasnehe/Liasnehe
Genetic Background: C3Fe.B6-Liasnehe

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

 MP:0012138 decreased forebrain size "size reduction or truncation of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
Show

Allelic Composition: Ift172wim/Ift172wim
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0012157 rostral body truncation "rostral part of body truncated; typically with the caudal portion of the body relatively normal" [MGI:csmith]
Show

Allelic Composition: Liasnehe/Liasnehe
Genetic Background: C3Fe.B6-Liasnehe

Allelic Composition: Liasnehe/Liastm1Mae
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000034424 Gcsh / Q91WK5 / Glycine cleavage system H protein, mitochondrial / P23434* / AC092718.3* / AC092718.8* / glycine cleavage system protein H*  / reaction






 

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