ENSDARG00000015149


Danio rerio

Features
Gene ID: ENSDARG00000015149
  
Biological name :wasa
  
Synonyms : wasa / Wiskott-Aldrich syndrome (eczema-thrombocytopenia) a
  
Possible biological names infered from orthology : P42768 / P70315 / WAS / Wiskott-Aldrich syndrome
  
Species: Danio rerio
  
Chr. number: 8
Strand: 1
Band:
Gene start: 25629722
Gene end: 25643932
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000007963
Ensembl peptide - ENSDARP00000154317
NCBI entrez gene - 571256     See in Manteia.
swissprot - F1Q6U7
ZFIN ID - ZDB-GENE-081104-419
Ensembl - ENSDARG00000015149
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 WASENSG00000015285Homo sapiens
 WasENSMUSG00000031165Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
wasb / Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b / WAS* / P70315* / P42768* / Wiskott-Aldrich syndrome*ENSDARG0000002635035
wasla / Wiskott-Aldrich syndrome-like a / WASL* / Q91YD9* / O00401* / Wiskott-Aldrich syndrome like* / Wiskott-Aldrich syndrome-like (human)*ENSDARG0000001411333
waslb / Wiskott-Aldrich syndrome-like b / WASL* / Q91YD9* / O00401* / Wiskott-Aldrich syndrome like* / Wiskott-Aldrich syndrome-like (human)*ENSDARG0000000628331
si:dkey-197j19.6ENSDARG0000009062812


Protein motifs (from Interpro)
Interpro ID Name
 IPR000095  CRIB domain
 IPR000697  WH1/EVH1 domain
 IPR003124  WH2 domain
 IPR011026  Wiscott-Aldrich syndrome protein, C-terminal
 IPR011993  PH-like domain superfamily
 IPR027641  Wiskott-Aldrich syndrome protein
 IPR033927  WASP family, EVH1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation IEA
 molecular_functionGO:0003779 actin binding IEA


Pathways (from Reactome)
Pathway description
Generation of second messenger molecules
Regulation of actin dynamics for phagocytic cup formation
RHO GTPases Activate WASPs and WAVEs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism viability , abnormal
whole organism decreased life span , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000105276 grb2a / growth factor receptor-bound protein 2a / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction
 ENSDARG00000045298 wipf2a / WAS/WASL interacting protein family, member 2a / WIPF2* / Q6PEV3* / Q8TF74* / WAS/WASL interacting protein family member 2*  / reaction
 ENSDARG00000071084 wipf1b / WAS/WASL interacting protein family, member 1b / WIPF1* / O43516* / Q8K1I7* / WAS/WASL interacting protein family member 1*  / reaction
 ENSDARG00000079475 nckipsd / NCK interacting protein with SH3 domain / Q9NZQ3*  / reaction
 ENSDARG00000038059 grb2b / growth factor receptor-bound protein 2b / GRB2* / Q60631* / P62993* / growth factor receptor bound protein 2*  / reaction
 ENSDARG00000104300 wipf1a / WAS/WASL interacting protein family, member 1a / WIPF1* / O43516* / Q8K1I7* / WAS/WASL interacting protein family member 1*  / reaction
 ENSDARG00000075369 nck1b / NCK adaptor protein 1b / NCK1* / P16333* / Q99M51* / NCK adaptor protein 1* / Cytoplasmic protein NCK1 *  / reaction / complex
 ENSDARG00000044573 cdc42 / cell division cycle 42 / P60766* / P60953* / Cell division control *  / complex






 

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