ENSDARG00000026350


Danio rerio

Features
Gene ID: ENSDARG00000026350
  
Biological name :wasb
  
Synonyms : wasb / Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b
  
Possible biological names infered from orthology : P42768 / P70315 / WAS / Wiskott-Aldrich syndrome
  
Species: Danio rerio
  
Chr. number: 8
Strand: -1
Band:
Gene start: 23560183
Gene end: 23578660
  
Corresponding Affymetrix probe sets: Dr.23314.1.S1_at (Zebrafish Array)   NM_199938_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000039217
Ensembl peptide - ENSDARP00000114931
NCBI entrez gene - 335158     See in Manteia.
RefSeq - NM_199938
RefSeq Peptide - NP_956232
swissprot - B0S5G8
swissprot - B0S5G7
ZFIN ID - ZDB-GENE-030131-7098
Ensembl - ENSDARG00000026350
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 WASENSG00000015285Homo sapiens
 WasENSMUSG00000031165Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
wasla / Wiskott-Aldrich syndrome-like a / WASL* / Q91YD9* / O00401* / Wiskott-Aldrich syndrome like* / Wiskott-Aldrich syndrome-like (human)*ENSDARG0000001411347
wasa / Wiskott-Aldrich syndrome (eczema-thrombocytopenia) a / WAS* / P70315* / P42768* / Wiskott-Aldrich syndrome*ENSDARG0000001514946
waslb / Wiskott-Aldrich syndrome-like b / WASL* / Q91YD9* / O00401* / Wiskott-Aldrich syndrome like* / Wiskott-Aldrich syndrome-like (human)*ENSDARG0000000628344
si:dkey-197j19.6ENSDARG0000009062815


Protein motifs (from Interpro)
Interpro ID Name
 IPR000095  CRIB domain
 IPR000697  WH1/EVH1 domain
 IPR003124  WH2 domain
 IPR011026  Wiscott-Aldrich syndrome protein, C-terminal
 IPR011993  PH-like domain superfamily
 IPR027641  Wiskott-Aldrich syndrome protein
 IPR033927  WASP family, EVH1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0030593 neutrophil chemotaxis IMP
 biological_processGO:0030595 leukocyte chemotaxis IMP
 biological_processGO:0048246 macrophage chemotaxis IMP
 biological_processGO:1902622 regulation of neutrophil migration IMP
 biological_processGO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation IEA
 molecular_functionGO:0003779 actin binding IEA


Pathways (from Reactome)
Pathway description
Generation of second messenger molecules
Regulation of actin dynamics for phagocytic cup formation
RHO GTPases Activate WASPs and WAVEs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism decreased life span , abnormal
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 ZFA:0009141 macrophage macrophage decreased amount , abnormal
macrophage phagocytosis arrested , abnormal
macrophage phagocytosis delayed , abnormal
macrophage phagocytosis, engulfment delayed , abnormal
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 ZFA:0009327 neutrophil neutrophil decreased amount , abnormal
neutrophil decreased velocity , abnormal
neutrophil pseudopodium assembly decreased rate , abnormal
neutrophil uropod retraction decreased rate , abnormal
neutrophil pseudopodium organization decreased process quality , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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