ENSDARG00000016782


Danio rerio

Features
Gene ID: ENSDARG00000016782
  
Biological name :huwe1
  
Synonyms : HECT, UBA and WWE domain containing 1 / huwe1
  
Possible biological names infered from orthology : E3 ubiquitin-protein ligase HUWE1 / HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase / Q7TMY8 / Q7Z6Z7
  
Species: Danio rerio
  
Chr. number: 23
Strand: 1
Band:
Gene start: 28494189
Gene end: 28568978
  
Corresponding Affymetrix probe sets: Dr.18821.1.S1_at (Zebrafish Array)   Dr.26506.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000002767
Ensembl peptide - ENSDARP00000118265
swissprot - E7F8Q5
swissprot - F1QL68
ZFIN ID - ZDB-GENE-081104-387
Ensembl - ENSDARG00000016782
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HUWE1ENSG00000086758Homo sapiens
 Huwe1ENSMUSG00000025261Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ubr5 / ubiquitin protein ligase E3 component n-recognin 5 / O95071*ENSDARG000000181929
AREL1 / apoptosis resistant E3 ubiquitin protein ligase 1 / O15033*ENSDARG000001003595


Protein motifs (from Interpro)
Interpro ID Name
 IPR000569  HECT domain
 IPR004170  WWE domain
 IPR009060  UBA-like superfamily
 IPR010309  E3 ubiquitin ligase, domain of unknown function DUF908
 IPR010314  E3 ubiquitin ligase, domain of unknown function DUF913
 IPR011989  Armadillo-like helical
 IPR015940  Ubiquitin-associated domain
 IPR016024  Armadillo-type fold
 IPR018123  WWE domain, subgroup
 IPR025527  Domain of unknown function DUF4414


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016567 protein ubiquitination IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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