ENSMUSG00000025261


Mus musculus

Features
Gene ID: ENSMUSG00000025261
  
Biological name :Huwe1
  
Synonyms : E3 ubiquitin-protein ligase HUWE1 / Huwe1 / Q7TMY8
  
Possible biological names infered from orthology : HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase / Q7Z6Z7
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: F3
Gene start: 151800807
Gene end: 151935417
  
Corresponding Affymetrix probe sets: 10602501 (MoGene1.0st)   10338104 (MoGene1.0st)   10338147 (MoGene1.0st)   10338166 (MoGene1.0st)   10338474 (MoGene1.0st)   10338954 (MoGene1.0st)   10339093 (MoGene1.0st)   10339722 (MoGene1.0st)   10339931 (MoGene1.0st)   10340140 (MoGene1.0st)   10340269 (MoGene1.0st)   10340417 (MoGene1.0st)   10340497 (MoGene1.0st)   10341132 (MoGene1.0st)   10341459 (MoGene1.0st)   10341491 (MoGene1.0st)   10341971 (MoGene1.0st)   10342151 (MoGene1.0st)   10342603 (MoGene1.0st)   10342911 (MoGene1.0st)   10342939 (MoGene1.0st)   10343423 (MoGene1.0st)   10343504 (MoGene1.0st)   10344058 (MoGene1.0st)   10344161 (MoGene1.0st)   10344289 (MoGene1.0st)   10344332 (MoGene1.0st)   10344584 (MoGene1.0st)   10338679 (MoGene1.0st)   10339231 (MoGene1.0st)   10339524 (MoGene1.0st)   10339626 (MoGene1.0st)   10339762 (MoGene1.0st)   10340411 (MoGene1.0st)   10341958 (MoGene1.0st)   10342720 (MoGene1.0st)   10343916 (MoGene1.0st)   10343923 (MoGene1.0st)   10344184 (MoGene1.0st)   1415703_at (Mouse Genome 430 2.0 Array)   1424949_at (Mouse Genome 430 2.0 Array)   1443183_at (Mouse Genome 430 2.0 Array)   1444279_at (Mouse Genome 430 2.0 Array)   1448056_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118185
Ensembl peptide - ENSMUSP00000114862
Ensembl peptide - ENSMUSP00000120057
Ensembl peptide - ENSMUSP00000122612
Ensembl peptide - ENSMUSP00000026292
Ensembl peptide - ENSMUSP00000108241
Ensembl peptide - ENSMUSP00000114357
NCBI entrez gene - 59026     See in Manteia.
MGI - MGI:1926884
RefSeq - XM_017318587
RefSeq - XM_011247854
RefSeq - XM_011247855
RefSeq - XM_011247856
RefSeq - XM_011247857
RefSeq - XM_011247858
RefSeq - XM_011247859
RefSeq - XM_011247860
RefSeq - NM_021523
RefSeq - XM_006528933
RefSeq - XM_006528934
RefSeq - XM_006528935
RefSeq - XM_006528936
RefSeq - XM_006528937
RefSeq - XM_006528938
RefSeq - XM_006528939
RefSeq - XM_006528940
RefSeq - XM_006528943
RefSeq - XM_006528948
RefSeq - XM_006528949
RefSeq - XM_006528951
RefSeq - XM_011247852
RefSeq - XM_011247853
RefSeq Peptide - NP_067498
swissprot - F6UYC1
swissprot - F6XP90
swissprot - D6RDF2
swissprot - A0A0G2JD97
swissprot - Q7TMY8
swissprot - A2AFQ0
Ensembl - ENSMUSG00000025261
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 huwe1ENSDARG00000016782Danio rerio
 HUWE1ENSG00000086758Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ubr5 / ubiquitin protein ligase E3 component n-recognin 5 / O95071*ENSMUSG0000003748710
Arel1 / Q8CHG5 / Apoptosis-resistant E3 ubiquitin protein ligase 1 / O15033*ENSMUSG000000423506


Protein motifs (from Interpro)
Interpro ID Name
 IPR000569  HECT domain
 IPR004170  WWE domain
 IPR009060  UBA-like superfamily
 IPR010309  E3 ubiquitin ligase, domain of unknown function DUF908
 IPR010314  E3 ubiquitin ligase, domain of unknown function DUF913
 IPR011989  Armadillo-like helical
 IPR015940  Ubiquitin-associated domain
 IPR016024  Armadillo-type fold
 IPR025527  Domain of unknown function DUF4414
 IPR035983  HECT, E3 ligase catalytic domain
 IPR037197  WWE domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination ISS
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006284 base-excision repair ISO
 biological_processGO:0006513 protein monoubiquitination ISS
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0016574 histone ubiquitination ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion ISO
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISS
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Chrnetm2Vwi/Chrnetm2Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Relbtm1Brv/Relbtm1Brv
Genetic Background: involves: 129S2/SvPas

 MP:0000538 abnormal urinary bladder morphology "malformation of the inflatable musculomembranous bag for holding urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Huwe1tm1Wgu/Y
Genetic Background: involves: C57BL/6J

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0000790 abnormal stratification in cerebral cortex "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
Show

Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Huwe1tm1Wgu/Y
Genetic Background: involves: C57BL/6J

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Huwe1tm1Wgu/Y
Genetic Background: involves: C57BL/6J

Allelic Composition: Huwe1tm1Wgu/Y,Tg(Ins2-cre)23Herr/0,Trp53tm1Thl/Trp53tm1Thl
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0001685 abnormal endoderm development "failure or abnormality in the formation of the endoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fbxw4Dac/Fbxw4+,mdac/mdac
Genetic Background: involves: SM/Ckc * BALB/cByJ

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fbxw4Dac/Fbxw4+,mdac/mdac
Genetic Background: involves: SM/Ckc * BALB/cByJ

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Chrnetm2Vwi/Chrnetm2Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
Show

Allelic Composition: Relbtm1Brv/Relbtm1Brv
Genetic Background: involves: 129S2/SvPas

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Huwe1tm1Wgu/Y
Genetic Background: involves: C57BL/6J

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Chrnetm2Vwi/Chrnetm2Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Huwe1tm1.1Mak/Y
Genetic Background: B6.Cg-Cd79atm1(cre)Reth Huwe1tm1.1Mak

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Huwe1tm1.1Mak/Y,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Huwe1tm1.1Mak/Y
Genetic Background: B6.Cg-Cd79atm1(cre)Reth Huwe1tm1.1Mak

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Huwe1tm1Wgu/Y
Genetic Background: involves: C57BL/6J

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fbxw4Dac/Fbxw4+,mdac/mdac
Genetic Background: involves: SM/Ckc * BALB/cByJ

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Huwe1tm1.1Mak/Y
Genetic Background: B6.Cg-Cd79atm1(cre)Reth Huwe1tm1.1Mak

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ap3b1pe/Ap3b1pe-9J
Genetic Background: (B6.C3-Ap3b1pe x C57BL/6J-Ap3b1pe-9J)F1

Allelic Composition: Huwe1tm1Wgu/Y
Genetic Background: involves: C57BL/6J

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
Show

Allelic Composition: Relbtm1Brv/Relbtm1Brv
Genetic Background: involves: 129S2/SvPas

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Huwe1tm1.1Mak/Y
Genetic Background: B6.Cg-Cd79atm1(cre)Reth Huwe1tm1.1Mak

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Huwe1tm1Wgu/Y
Genetic Background: involves: C57BL/6J

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Huwe1tm1Wgu/Y
Genetic Background: involves: C57BL/6J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Relbtm1Brv/Relbtm1Brv
Genetic Background: involves: 129S2/SvPas

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Huwe1tm1.1Mak/Y
Genetic Background: B6.Cg-Cd79atm1(cre)Reth Huwe1tm1.1Mak

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Huwe1tm1.1Mak/Y,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0004980 increased neuronal precursor cell number "increased number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Huwe1tm1.1Mak/Y
Genetic Background: B6.Cg-Cd79atm1(cre)Reth Huwe1tm1.1Mak

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Huwe1tm1Wgu/Y
Genetic Background: involves: C57BL/6J

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Huwe1tm1Wgu/Y
Genetic Background: involves: C57BL/6J

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Huwe1tm1.1Mak/Y
Genetic Background: B6.Cg-Cd79atm1(cre)Reth Huwe1tm1.1Mak

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Huwe1tm1.1Mak/Y
Genetic Background: B6.Cg-Cd79atm1(cre)Reth Huwe1tm1.1Mak

 MP:0008190 decreased transitional stage B cell number "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Huwe1tm1.1Mak/Y
Genetic Background: B6.Cg-Cd79atm1(cre)Reth Huwe1tm1.1Mak

 MP:0008203 absent B-1a cells "absence of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
Show

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Huwe1tm1.1Mak/Y
Genetic Background: B6.Cg-Cd79atm1(cre)Reth Huwe1tm1.1Mak

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Huwe1tm1.1Mak/Y,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Huwe1tm1.1Mak/Y
Genetic Background: B6.Cg-Cd79atm1(cre)Reth Huwe1tm1.1Mak

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Huwe1tm1.1Mak/Y
Genetic Background: B6.Cg-Cd79atm1(cre)Reth Huwe1tm1.1Mak

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Huwe1tm1.1Mak/Y
Genetic Background: B6.Cg-Cd79atm1(cre)Reth Huwe1tm1.1Mak

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Huwe1tm1.1Mak/Y,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Huwe1tm1.1Mak/Y
Genetic Background: B6.Cg-Cd79atm1(cre)Reth Huwe1tm1.1Mak

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Huwe1tm1.1Mak/Y
Genetic Background: B6.Cg-Cd79atm1(cre)Reth Huwe1tm1.1Mak

 MP:0008782 increased B cell apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Huwe1tm1.1Mak/Y
Genetic Background: B6.Cg-Cd79atm1(cre)Reth Huwe1tm1.1Mak

 MP:0009254 disorganized pancreatic islets "derangement of the normal pattern of the hormone-producing cells within an islet; normally, the beta cells occupy the central portion of the islet and are surrounded by a corona of alpha and delta cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Huwe1tm1Wgu/Y
Genetic Background: involves: C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Chrnetm2Vwi/Chrnetm2Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Relbtm1Brv/Relbtm1Brv
Genetic Background: involves: 129S2/SvPas

 MP:0011732 decreased somite size "reduced size of any of the segmental masses along the notochord of the developing embryo" [MGI:smb]
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Allelic Composition: Chrnetm2Vwi/Chrnetm2Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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