ENSMUSG00000037487


Mus musculus

Features
Gene ID: ENSMUSG00000037487
  
Biological name :Ubr5
  
Synonyms : ubiquitin protein ligase E3 component n-recognin 5 / Ubr5
  
Possible biological names infered from orthology : O95071
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: B3.1
Gene start: 37967328
Gene end: 38078854
  
Corresponding Affymetrix probe sets: 10428238 (MoGene1.0st)   1444327_at (Mouse Genome 430 2.0 Array)   1452718_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105965
Ensembl peptide - ENSMUSP00000153778
Ensembl peptide - ENSMUSP00000154132
Ensembl peptide - ENSMUSP00000154293
NCBI entrez gene - 70790     See in Manteia.
MGI - MGI:1918040
RefSeq - XM_006520183
RefSeq - NM_001081359
RefSeq - NM_001112721
RefSeq - XM_006520180
RefSeq - XM_006520181
RefSeq - XM_006520182
RefSeq - XM_006520179
RefSeq Peptide - NP_001074828
RefSeq Peptide - NP_001106192
swissprot - E9Q2H1
Ensembl - ENSMUSG00000037487
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ubr5ENSDARG00000018192Danio rerio
 UBR5ENSGALG00000031282Gallus gallus
 UBR5ENSG00000104517Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Huwe1 / Q7TMY8 / E3 ubiquitin-protein ligase HUWE1 / Q7Z6Z7* / HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase*ENSMUSG0000002526116
Arel1 / Q8CHG5 / Apoptosis-resistant E3 ubiquitin protein ligase 1 / O15033*ENSMUSG000000423506


Protein motifs (from Interpro)
Interpro ID Name
 IPR000569  HECT domain
 IPR002004  Polyadenylate-binding protein/Hyperplastic disc protein
 IPR003126  Zinc finger, UBR-type
 IPR009091  Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
 IPR024725  E3 ubiquitin ligase EDD, ubiquitin-associated domain
 IPR035983  HECT, E3 ligase catalytic domain
 IPR036053  PABC (PABP) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IDA
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0033160 positive regulation of protein import into nucleus, translocation IMP
 biological_processGO:0050847 progesterone receptor signaling pathway IDA
 biological_processGO:0070936 protein K48-linked ubiquitination IDA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IMP
 biological_processGO:1901315 negative regulation of histone H2A K63-linked ubiquitination IMP
 biological_processGO:2000780 negative regulation of double-strand break repair IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0034450 ubiquitin-ubiquitin ligase activity IDA
 molecular_functionGO:0043130 ubiquitin binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0006346 small branchial arch "reduced size of one or more of the branchial arches" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Prdm1tm1Clme/Prdm1tm1Clme
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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