ENSG00000104517


Homo sapiens

Features
Gene ID: ENSG00000104517
  
Biological name :UBR5
  
Synonyms : O95071 / ubiquitin protein ligase E3 component n-recognin 5 / UBR5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q22.3
Gene start: 102253012
Gene end: 102412841
  
Corresponding Affymetrix probe sets: 208882_s_at (Human Genome U133 Plus 2.0 Array)   208883_at (Human Genome U133 Plus 2.0 Array)   208884_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000428138
Ensembl peptide - ENSP00000428062
Ensembl peptide - ENSP00000428693
Ensembl peptide - ENSP00000429127
Ensembl peptide - ENSP00000429084
Ensembl peptide - ENSP00000220959
Ensembl peptide - ENSP00000427819
NCBI entrez gene - 51366     See in Manteia.
OMIM - 608413
RefSeq - XM_017013534
RefSeq - NM_001282873
RefSeq - NM_015902
RefSeq - XM_005250962
RefSeq - XM_011517104
RefSeq - XM_011517105
RefSeq - XM_011517106
RefSeq - XM_017013533
RefSeq Peptide - NP_056986
RefSeq Peptide - NP_001269802
swissprot - E7EMW7
swissprot - H0YAV7
swissprot - H0YBB4
swissprot - O95071
swissprot - E5RFK7
swissprot - E7ET84
Ensembl - ENSG00000104517
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ubr5ENSDARG00000018192Danio rerio
 UBR5ENSGALG00000031282Gallus gallus
 Ubr5ENSMUSG00000037487Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HUWE1 / Q7Z6Z7 / HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligaseENSG0000008675816
AREL1 / O15033 / apoptosis resistant E3 ubiquitin protein ligase 1ENSG000001196826


Protein motifs (from Interpro)
Interpro ID Name
 IPR000569  HECT domain
 IPR002004  Polyadenylate-binding protein/Hyperplastic disc protein
 IPR003126  Zinc finger, UBR-type
 IPR009091  Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
 IPR024725  E3 ubiquitin ligase EDD, ubiquitin-associated domain
 IPR035983  HECT, E3 ligase catalytic domain
 IPR036053  PABC (PABP) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IDA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0033160 positive regulation of protein import into nucleus, translocation IMP
 biological_processGO:0050847 progesterone receptor signaling pathway IDA
 biological_processGO:0070936 protein K48-linked ubiquitination IDA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IMP
 biological_processGO:1901315 negative regulation of histone H2A K63-linked ubiquitination IMP
 biological_processGO:2000780 negative regulation of double-strand break repair IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0034450 ubiquitin-ubiquitin ligase activity IDA
 molecular_functionGO:0043130 ubiquitin binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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