ENSG00000119682


Homo sapiens

Features
Gene ID: ENSG00000119682
  
Biological name :AREL1
  
Synonyms : apoptosis resistant E3 ubiquitin protein ligase 1 / AREL1 / O15033
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q24.3
Gene start: 74653437
Gene end: 74713115
  
Corresponding Affymetrix probe sets: 1554989_at (Human Genome U133 Plus 2.0 Array)   202128_at (Human Genome U133 Plus 2.0 Array)   244137_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000452456
Ensembl peptide - ENSP00000451710
Ensembl peptide - ENSP00000452101
Ensembl peptide - ENSP00000348714
Ensembl peptide - ENSP00000450458
Ensembl peptide - ENSP00000450557
Ensembl peptide - ENSP00000450901
Ensembl peptide - ENSP00000450912
Ensembl peptide - ENSP00000451375
NCBI entrez gene - 9870     See in Manteia.
OMIM - 615380
RefSeq - XM_011537417
RefSeq - NM_001039479
RefSeq - XM_005268244
RefSeq - XM_006720344
RefSeq - XM_011537415
RefSeq - XM_011537416
RefSeq Peptide - NP_001034568
swissprot - H0YJK5
swissprot - G3V245
swissprot - O15033
swissprot - G3V2B5
swissprot - G3V506
swissprot - G3V5P7
swissprot - H0YJ67
swissprot - H0YJF1
swissprot - H0YJ69
Ensembl - ENSG00000119682
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AREL1ENSDARG00000100359Danio rerio
 AREL1ENSGALG00000010270Gallus gallus
 Arel1ENSMUSG00000042350Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HUWE1 / Q7Z6Z7 / HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligaseENSG0000008675830
UBR5 / O95071 / ubiquitin protein ligase E3 component n-recognin 5ENSG0000010451720


Protein motifs (from Interpro)
Interpro ID Name
 IPR000408  Regulator of chromosome condensation, RCC1
 IPR000569  HECT domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR017868  Filamin/ABP280 repeat-like
 IPR035983  HECT, E3 ligase catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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