ENSDARG00000018329


Danio rerio

Features
Gene ID: ENSDARG00000018329
  
Biological name :gc2
  
Synonyms : gc2 / guanylyl cyclase 2
  
Possible biological names infered from orthology : guanylate cyclase 2F, retinal / GUCY2F / P51841 / Q5SDA5 / Retinal guanylyl cyclase 2
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 51267478
Gene end: 51300277
  
Corresponding Affymetrix probe sets: Dr.20997.1.A1_at (Zebrafish Array)   Dr.20997.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000143153
Ensembl peptide - ENSDARP00000089419
NCBI entrez gene - 140425     See in Manteia.
RefSeq - NM_001109695
RefSeq Peptide - NP_001103165
swissprot - E7F111
ZFIN ID - ZDB-GENE-011128-8
Ensembl - ENSDARG00000018329
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GUCY2FENSG00000101890Homo sapiens
 Gucy2fENSMUSG00000042282Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
gucy2f / guanylate cyclase 2F, retinalENSDARG0000002550458
gucy2d / guanylate cyclase 2D, retinal / Gucy2e* / P52785* / Q02846* / Guanylyl cyclase GC-E *ENSDARG0000002682052
npr1b / natriuretic peptide receptor 1b / NPR1* / P16066* / P18293* / natriuretic peptide receptor 1*ENSDARG0000001875029
npr1a / natriuretic peptide receptor 1a / NPR1* / P16066* / P18293* / natriuretic peptide receptor 1*ENSDARG0000003175129
npr2 / natriuretic peptide receptor 2 / P20594*ENSDARG0000010439329
gucy2g / guanylate cyclase 2g / Q6TL19*ENSDARG0000007677628
si:dkey-37g12.1ENSDARG0000006026428
si:ch73-139e5.4 / GUCY2C* / P25092* / Q3UWA6* / guanylate cyclase 2C* / Heat-stable enterotoxin receptor *ENSDARG0000005604526
gucy2c / guanylate cyclase 2C / P25092*ENSDARG0000001432026
gucy1b2 / guanylate cyclase 1, soluble, beta 2ENSDARG0000005659116
GUCY1A2 / guanylate cyclase 1 soluble subunit alpha 2 / P33402*ENSDARG0000009318513
gucy1a1 / guanylate cyclase 1 soluble subunit alpha 1 / Q02108* / Q9ERL9* / guanylate cyclase 1, soluble, alpha 1*ENSDARG0000001378713
gucy1b1 / guanylate cyclase 1 soluble subunit beta 1 / O54865* / Q02153* / guanylate cyclase 1, soluble, beta 1*ENSDARG0000008679012
si:ch211-215j19.12ENSDARG0000010407210
si:dkey-239n17.6ENSDARG000000958482


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001054  Adenylyl cyclase class-3/4/guanylyl cyclase
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001828  Receptor, ligand binding region
 IPR011009  Protein kinase-like domain superfamily
 IPR011645  Haem NO binding associated
 IPR018297  Adenylyl cyclase class-4/guanylyl cyclase, conserved site
 IPR028082  Periplasmic binding protein-like I
 IPR029787  Nucleotide cyclase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006182 cGMP biosynthetic process IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0009190 cyclic nucleotide biosynthetic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0008074 guanylate cyclase complex, soluble IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004383 guanylate cyclase activity IBA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016849 phosphorus-oxygen lyase activity IEA


Pathways (from Reactome)
Pathway description
Inactivation, recovery and regulation of the phototransduction cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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