ENSDARG00000024204


Danio rerio

Features
Gene ID: ENSDARG00000024204
  
Biological name :mcm3
  
Synonyms : mcm3 / minichromosome maintenance complex component 3
  
Possible biological names infered from orthology : P25205 / P25206
  
Species: Danio rerio
  
Chr. number: 20
Strand: 1
Band:
Gene start: 34770197
Gene end: 34783743
  
Corresponding Affymetrix probe sets: Dr.20948.1.S1_at (Zebrafish Array)   Dr.784.1.S1_at (Zebrafish Array)   NM_212567_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000003671
NCBI entrez gene - 192323     See in Manteia.
RefSeq - NM_212567
RefSeq Peptide - NP_997732
swissprot - Q5RIC5
ZFIN ID - ZDB-GENE-020419-4
Ensembl - ENSDARG00000024204
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MCM3ENSGALG00000016676Gallus gallus
 MCM3ENSG00000112118Homo sapiens
 Mcm3ENSMUSG00000041859Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mcm3l / MCM3 minichromosome maintenance deficient 3 (S. cerevisiae), likeENSDARG0000003753270


Protein motifs (from Interpro)
Interpro ID Name
 IPR001208  MCM domain
 IPR003593  AAA+ ATPase domain
 IPR008046  DNA replication licensing factor Mcm3
 IPR012340  Nucleic acid-binding, OB-fold
 IPR018525  Mini-chromosome maintenance, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027925  MCM N-terminal domain
 IPR031327  Mini-chromosome maintenance protein
 IPR033762  MCM OB domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006270 DNA replication initiation IEA
 biological_processGO:0060041 retina development in camera-type eye IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0042555 MCM complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
Switching of origins to a post-replicative state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000112 gut gut hypoplastic , abnormal
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 ZFA:0000123 liver liver hypoplastic , abnormal
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 ZFA:0000152 retina retina quality , abnormal
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 ZFA:0000282 sensory system sensory system quality , abnormal
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 ZFA:0000445 optic tectum optic tectum necrotic , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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