| MP:0000208 | decreased hematocrit | "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Mcm3tm1.1Geno/Mcm3tm1.1Geno
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0000245 | abnormal erythropoiesis | "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: Mcm3tm1.1Geno/Mcm3tm1.1Geno
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0000609 | abnormal liver physiology | "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Lpltm1Bres/Lpl+,Tg(Myh6-LPL*)357Ijg/0
Genetic Background: involves: 129S4/SvJae
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| MP:0001272 | increased metastatic potential | |
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Allelic Composition: Mcm3tm1.1Geno/Mcm3+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Mcm3tm1.2Geno/Mcm3+
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0002020 | increased tumor incidence | "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193] |
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J
Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J
Allelic Composition: Mcm3tm1.1Geno/Mcm3+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Mcm3tm1.2Geno/Mcm3+
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J
Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4Gt(RRE056)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J
Allelic Composition: Mcm3tm1.1Geno/Mcm3+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Mcm3tm1.2Geno/Mcm3+
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0002399 | abnormal pluripotent precursor cell morphology/development | "anomalous structure or fomation of the cells that give rise to most types of cells necessary for fetal development" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J
Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J
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| MP:0002416 | abnormal proerythroblast morphology/development | "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Mcm3tm1.1Geno/Mcm3tm1.1Geno
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0002447 | abnormal erythrocyte morphology | "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J
Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ
Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ
Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ
Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ
Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ
Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ
Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ
Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ
Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ
Allelic Composition: Mcm3tm1.1Geno/Mcm3tm1.1Geno
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0002874 | decreased hemoglobin content | "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Mcm3tm1.1Geno/Mcm3tm1.1Geno
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0003077 | abnormal cell cycle | "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266] |
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Allelic Composition: Mcm3tm1.1Geno/Mcm3tm1.1Geno
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0003717 | pallor | "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Mcm3tm1.1Geno/Mcm3tm1.1Geno
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0004200 | reduced fetal size | "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mcm3tm1.1Geno/Mcm3tm1.1Geno
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0004809 | increased hematopoietic stem cell number | "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mcm3tm1.1Geno/Mcm3tm1.1Geno
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0006042 | increased apoptosis | "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Mcm3tm1.1Geno/Mcm3tm1.1Geno
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0008057 | abnormal DNA replication | "any anomaly in the process whereby new strands of DNA are synthesized" [GO:0006260] |
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Allelic Composition: Mcm3tm1.1Geno/Mcm3tm1.1Geno
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0008866 | chromosomal instability | "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840] |
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J
Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ
Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ
Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ
Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ
Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ
Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ
Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ
Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ
Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4Gt(RRE056)Byg/Mcm4+,Mcm6Gt(YHD248)Byg/Mcm6+,Mcm7Gt(YTA285)Byg/Mcm7+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ
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| MP:0010299 | increased mammary gland tumor incidence | "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4Gt(RRE056)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J
Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J
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| MP:0010308 | decreased tumor latency | "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mcm3tm1.1Geno/Mcm3+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Mcm3tm1.2Geno/Mcm3+
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J
Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4Gt(RRE056)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J
Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J
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| MP:0011090 | partial perinatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Mcm3tm1.1Geno/Mcm3tm1.1Geno
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0011091 | complete prenatal lethality | "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ
Allelic Composition: Mcm3tm1.2Geno/Mcm3tm1.2Geno
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0011101 | partial prenatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Mcm3tm1.1Geno/Mcm3+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Mcm3tm1.1Geno/Mcm3tm1.1Geno,Tg(Chek1)1Ofc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CD-1
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| MP:0011178 | increased erythroblast number | "greater number of the nucleated precursor of erythrocytes" [MGI:csmith] |
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Allelic Composition: Mcm3tm1.1Geno/Mcm3tm1.1Geno
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0011243 | decreased fetal derived definitive erythrocyte cell number | "reduced number of fetal liver derived enucleated erythrocytes, which mature in macrophage islands within the liver, enucleate, and then enter the bloodstream; these resemble adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemoglobins" [CL:0002357, PMID:18282515] |
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Allelic Composition: Mcm3tm1.1Geno/Mcm3tm1.1Geno
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0011704 | decreased fibroblast proliferation | "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith] |
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Allelic Composition: Mcm2Gt(AB0178)Wtsi/Mcm2+,Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J
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| MP:0011903 | decreased hematopoietic stem cell proliferation | "reduction in the expansion rate of a hematopoietic stem cell population by cell division" [MGI:csmith] |
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Allelic Composition: Mcm3tm1.1Geno/Mcm3tm1.1Geno
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0011913 | abnormal reticulocyte cell number | "altered number of immature (nucleated) erythrocytes" [MPD:Molly] |
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Allelic Composition: Mcm3tm1.1Geno/Mcm3tm1.1Geno
Genetic Background: involves: 129S2/SvPas * C57BL/6
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| MP:0012431 | increased lymphoma incidence | "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith] |
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Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4Gt(RRE056)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J
Allelic Composition: Mcm3Gt(RRR002)Byg/Mcm3+,Mcm4chaos3/Mcm4chaos3,Mcm6Gt(YHD248)Byg/Mcm6+
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J
Allelic Composition: Mcm3tm1.1Geno/Mcm3+
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Mcm3tm1.2Geno/Mcm3+
Genetic Background: involves: 129S2/SvPas * C57BL/6
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