ENSG00000112118


Homo sapiens

Features
Gene ID: ENSG00000112118
  
Biological name :MCM3
  
Synonyms : MCM3 / minichromosome maintenance complex component 3 / P25205
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p12.2
Gene start: 52264009
Gene end: 52284881
  
Corresponding Affymetrix probe sets: 201555_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000470057
Ensembl peptide - ENSP00000480987
Ensembl peptide - ENSP00000472940
Ensembl peptide - ENSP00000229854
Ensembl peptide - ENSP00000388647
Ensembl peptide - ENSP00000407651
NCBI entrez gene - 4172     See in Manteia.
OMIM - 602693
RefSeq - NM_002388
RefSeq - NM_001270472
RefSeq Peptide - NP_001257401
RefSeq Peptide - NP_002379
swissprot - Q7Z6P5
swissprot - J3KQ69
swissprot - M0QYS9
swissprot - P25205
swissprot - A0A0S2Z4T1
Ensembl - ENSG00000112118
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mcm3ENSDARG00000024204Danio rerio
 MCM3ENSGALG00000016676Gallus gallus
 Mcm3ENSMUSG00000041859Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001208  MCM domain
 IPR003593  AAA+ ATPase domain
 IPR008046  DNA replication licensing factor Mcm3
 IPR012340  Nucleic acid-binding, OB-fold
 IPR018525  Mini-chromosome maintenance, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027925  MCM N-terminal domain
 IPR031327  Mini-chromosome maintenance protein
 IPR033762  MCM OB domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle TAS
 biological_processGO:0006260 DNA replication TAS
 biological_processGO:0006270 DNA replication initiation TAS
 biological_processGO:0007049 cell cycle IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region HDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005658 alpha DNA polymerase:primase complex TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0042555 MCM complex IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
Unwinding of DNA
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
Switching of origins to a post-replicative state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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