ENSDARG00000026811


Danio rerio

Features
Gene ID: ENSDARG00000026811
  
Biological name :extl3
  
Synonyms : exostosin-like glycosyltransferase 3 / extl3
  
Possible biological names infered from orthology : O43909
  
Species: Danio rerio
  
Chr. number: 20
Strand: -1
Band:
Gene start: 49940818
Gene end: 50014936
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000124029
Ensembl peptide - ENSDARP00000155128
NCBI entrez gene - 493783     See in Manteia.
RefSeq - XM_005170211
RefSeq - NM_001008402
RefSeq Peptide - NP_001008402
swissprot - Q5U7D2
ZFIN ID - ZDB-GENE-041124-2
Ensembl - ENSDARG00000026811
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EXTL3ENSGALG00000016630Gallus gallus
 EXTL3ENSG00000012232Homo sapiens
 Extl3ENSMUSG00000021978Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ext2 / exostosin glycosyltransferase 2 / P70428* / Q93063* / Mus musculus exostoses (multiple) 2 (Ext2), transcript variant 1, mRNA.*ENSDARG0000005664827
ext1a / Q5IGR8 / exostosin glycosyltransferase 1a / EXT1* / P97464* / Q16394* / Exostosin-1 * / exostosin glycosyltransferase 1*ENSDARG0000010315523
ext1b / exostosin glycosyltransferase 1b / EXT1* / Q16394* / exostosin glycosyltransferase 1*ENSDARG0000010101922
extl2 / exostosin-like glycosyltransferase 2 / Q9ES89* / Q9UBQ6* / Exostosin-like 2 *ENSDARG0000006319110
ext1c / exostoses (multiple) 1c / EXTL1* / Q92935* / Q9JKV7* / Exostosin-like 1 * / exostosin like glycosyltransferase 1*ENSDARG000000356496


Protein motifs (from Interpro)
Interpro ID Name
 IPR004263  Exostosin-like
 IPR015338  Exostosin , C-terminal
 IPR029044  Nucleotide-diphospho-sugar transferases


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0015012 heparan sulfate proteoglycan biosynthetic process IMP
 biological_processGO:0030516 regulation of axon extension IMP
 biological_processGO:0031290 retinal ganglion cell axon guidance IMP
 biological_processGO:0033339 pectoral fin development IMP
 biological_processGO:0033564 anterior/posterior axon guidance IGI
 biological_processGO:0035118 embryonic pectoral fin morphogenesis IMP
 biological_processGO:0035138 pectoral fin morphogenesis IMP
 biological_processGO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway IMP
 biological_processGO:0048538 thymus development IMP
 biological_processGO:0050650 chondroitin sulfate proteoglycan biosynthetic process IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001888 glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity ISS
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000095 pharyngeal arch 3-7 skeleton pharyngeal arch 3-7 skeleton quality , abnormal
pharyngeal arch 3-7 skeleton decreased length , abnormal
pharyngeal arch 3-7 skeleton increased thickness , abnormal
pharyngeal arch 3-7 skeleton decreased size , abnormal
pharyngeal arch 3-7 skeleton increased width , abnormal
Show

 ZFA:0000101 diencephalon diencephalon dorsal region flattened , abnormal
Show

 ZFA:0000108 fin fin decreased size , abnormal
Show

 ZFA:0000128 midbrain midbrain dorsal region flattened , abnormal
Show

 ZFA:0000217 inner ear inner ear increased size , abnormal
inner ear morphology , abnormal
Show

 ZFA:0000252 optic tract optic tract structure , abnormal
Show

 ZFA:0000292 surface structure surface structure quality , abnormal
Show

 ZFA:0000354 gill gill decreased size , abnormal
Show

 ZFA:0000396 nervous system nervous system quality , abnormal
Show

 ZFA:0000547 mouth mouth quality , abnormal
Show

 ZFA:0000655 dorsomedial optic tract dorsomedial optic tract composition , abnormal
Show

 ZFA:0001078 thymus thymus decreased volume , abnormal
thymus decreased distribution , abnormal
thymus decreased amount , abnormal
Show

 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism viability , abnormal
whole organism decreased behavioural activity , abnormal
Show

 ZFA:0001161 pectoral fin pectoral fin quality , abnormal
pectoral fin cell circular , abnormal
pectoral fin decreased size , abnormal
pectoral fin decreased length , abnormal
pectoral fin distal region degenerate , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage decreased length , abnormal
Meckels cartilage increased thickness , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton morphology , abnormal
mandibular arch skeleton decreased length , abnormal
mandibular arch skeleton increased thickness , abnormal
mandibular arch skeleton decreased size , abnormal
mandibular arch skeleton increased mass , abnormal
mandibular arch skeleton condensed , abnormal
mandibular arch skeleton increased width , abnormal
mandibular arch skeleton sloped downward , abnormal
Show

 ZFA:0001239 ceratobranchial 5 bone ceratobranchial 5 bone decreased length , abnormal
ceratobranchial 5 bone has fewer parts of type ceratobranchial 5 tooth , abnormal
Show

 ZFA:0001273 ventral mandibular arch ventral mandibular arch quality , abnormal
ventral mandibular arch morphology , abnormal
Show

 ZFA:0001276 pharyngeal arch 2 skeleton pharyngeal arch 2 skeleton quality , abnormal
pharyngeal arch 2 skeleton decreased length , abnormal
pharyngeal arch 2 skeleton increased thickness , abnormal
pharyngeal arch 2 skeleton decreased size , abnormal
pharyngeal arch 2 skeleton increased width , abnormal
Show

 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage decreased length , abnormal
ceratohyal cartilage increased thickness , abnormal
Show

 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage decreased length , abnormal
pharyngeal arch cartilage increased thickness , abnormal
pharyngeal arch cartilage chondrocyte organization quality , abnormal
pharyngeal arch cartilage decreased size , abnormal
Show

 ZFA:0001580 neurocranium neurocranium morphology , abnormal
Show

 ZFA:0001613 pharyngeal arch 3-7 pharyngeal arch 3-7 decreased size , abnormal
Show

 ZFA:0005317 pectoral fin fold pectoral fin fold aplastic , abnormal
pectoral fin fold distal region aplastic , abnormal
Show

 ZFA:0009084 chondrocyte chondrocyte shape , abnormal
Show

 ZFA:0009301 dopaminergic neuron dopaminergic neuron axon mislocalised medially , abnormal
dopaminergic neuron axon adjacent to hindbrain anterior-posterior axis, abnormal
Show

 ZFA:0009310 retinal ganglion cell retinal ganglion cell axon misrouted , abnormal
retinal ganglion cell axon branched , abnormal
retinal ganglion cell axon displaced , abnormal
retinal ganglion cell axon organization quality , abnormal
retinal ganglion cell axon irregular spatial pattern , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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