ENSMUSG00000021978


Mus musculus

Features
Gene ID: ENSMUSG00000021978
  
Biological name :Extl3
  
Synonyms : exostosin like glycosyltransferase 3 / Extl3
  
Possible biological names infered from orthology : O43909
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: D1
Gene start: 65052060
Gene end: 65149855
  
Corresponding Affymetrix probe sets: 10420837 (MoGene1.0st)   1421339_at (Mouse Genome 430 2.0 Array)   1434703_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022550
Ensembl peptide - ENSMUSP00000153547
NCBI entrez gene - 54616     See in Manteia.
MGI - MGI:1860765
RefSeq - XM_006519286
RefSeq - NM_018788
RefSeq - XM_006519284
RefSeq - XM_006519285
RefSeq Peptide - NP_061258
swissprot - Q6P1H4
Ensembl - ENSMUSG00000021978
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 extl3ENSDARG00000026811Danio rerio
 EXTL3ENSGALG00000016630Gallus gallus
 EXTL3ENSG00000012232Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ext2 / P70428 / Mus musculus exostoses (multiple) 2 (Ext2), transcript variant 1, mRNA. / Q93063* / exostosin glycosyltransferase 2*ENSMUSG0000002719827
Ext1 / P97464 / Exostosin-1 / Q16394* / exostosin glycosyltransferase 1*ENSMUSG0000006173123
Extl1 / Q9JKV7 / Exostosin-like 1 / Q92935* / exostosin like glycosyltransferase 1*ENSMUSG0000002883819
Extl2 / Q9ES89 / Exostosin-like 2 / Q9UBQ6* / exostosin like glycosyltransferase 2*ENSMUSG0000002796310


Protein motifs (from Interpro)
Interpro ID Name
 IPR004263  Exostosin-like
 IPR015338  Exostosin , C-terminal
 IPR029044  Nucleotide-diphospho-sugar transferases


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0015012 heparan sulfate proteoglycan biosynthetic process IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nototm1(cre/ERT2)Hssk/Nototm1(cre/ERT2)Hssk
Genetic Background: involves: C57BL/6 * CBA

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nototm1(cre/ERT2)Hssk/Nototm1(cre/ERT2)Hssk
Genetic Background: involves: C57BL/6 * CBA

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Nototm1(cre/ERT2)Hssk/Nototm1(cre/ERT2)Hssk
Genetic Background: involves: C57BL/6 * CBA

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nototm1(cre/ERT2)Hssk/Nototm1(cre/ERT2)Hssk
Genetic Background: involves: C57BL/6 * CBA

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nototm1(cre/ERT2)Hssk/Nototm1(cre/ERT2)Hssk
Genetic Background: involves: C57BL/6 * CBA

 MP:0009114 decreased pancreatic beta cell mass "reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nototm1(cre/ERT2)Hssk/Nototm1(cre/ERT2)Hssk
Genetic Background: involves: C57BL/6 * CBA

 MP:0009254 disorganized pancreatic islets "derangement of the normal pattern of the hormone-producing cells within an islet; normally, the beta cells occupy the central portion of the islet and are surrounded by a corona of alpha and delta cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nototm1(cre/ERT2)Hssk/Nototm1(cre/ERT2)Hssk
Genetic Background: involves: C57BL/6 * CBA

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Mertktm1Gkm/Mertktm1Gkm
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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