ENSDARG00000027234


Danio rerio

Features
Gene ID: ENSDARG00000027234
  
Biological name :ift88
  
Synonyms : ift88 / intraflagellar transport 88 homolog
  
Possible biological names infered from orthology : intraflagellar transport 88 / Q13099
  
Species: Danio rerio
  
Chr. number: 9
Strand: -1
Band:
Gene start: 21365043
Gene end: 21383489
  
Corresponding Affymetrix probe sets: Dr.2900.1.A1_at (Zebrafish Array)   NM_001001725_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000150029
Ensembl peptide - ENSDARP00000155661
Ensembl peptide - ENSDARP00000034047
Ensembl peptide - ENSDARP00000101727
Ensembl peptide - ENSDARP00000122577
NCBI entrez gene - 321855     See in Manteia.
RefSeq - NM_001001725
RefSeq - XM_005167531
RefSeq Peptide - NP_001001725
swissprot - F1QW32
swissprot - B0UYB0
swissprot - F1QVN7
ZFIN ID - ZDB-GENE-030131-574
Ensembl - ENSDARG00000027234
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000017134Gallus gallus
 ENSGALG00000043412Gallus gallus
 IFT88ENSG00000032742Homo sapiens
 Ift88ENSMUSG00000040040Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000132 establishment of mitotic spindle orientation IMP
 biological_processGO:0003351 epithelial cilium movement IMP
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0007369 gastrulation IMP
 biological_processGO:0042073 intraciliary transport IMP
 biological_processGO:0042462 eye photoreceptor cell development IMP
 biological_processGO:0045494 photoreceptor cell maintenance IMP
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IMP
 biological_processGO:0060122 inner ear receptor cell stereocilium organization IMP
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:0060785 regulation of apoptosis involved in tissue homeostasis IMP
 biological_processGO:0071482 cellular response to light stimulus IMP
 biological_processGO:0072019 proximal convoluted tubule development IMP
 biological_processGO:1905515 non-motile cilium assembly IMP
 cellular_componentGO:0005929 cilium IDA
 cellular_componentGO:0005930 axoneme IDA
 cellular_componentGO:0031514 motile cilium IEA
 cellular_componentGO:0036064 ciliary basal body IDA


Pathways (from Reactome)
Pathway description
Hedgehog off state
Intraflagellar transport
Hedgehog on state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain hydrocephalic , abnormal
Show

 ZFA:0000009 cardiac ventricle cardiac ventricle decreased amount , abnormal
Show

 ZFA:0000022 floor plate floor plate lacks all parts of type floor plate motile cilium, abnormal
Show

 ZFA:0000029 hindbrain hindbrain has fewer parts of type branchiomotor neuron , abnormal
Show

 ZFA:0000041 mesoderm mesoderm cilium aplastic , abnormal
Show

 ZFA:0000051 otic vesicle otic vesicle decreased size , abnormal
otic vesicle cilium decreased length , abnormal
otic vesicle cilium decreased amount , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
eye quality , abnormal
Show

 ZFA:0000114 heart heart decreased amount , abnormal
Show

 ZFA:0000132 neural plate neural plate establishment of mitotic spindle orientation process quality , abnormal
Show

 ZFA:0000135 notochord notochord increased width , abnormal
notochord kinked , abnormal
Show

 ZFA:0000143 retinal photoreceptor layer retinal photoreceptor layer eye photoreceptor cell apoptotic , abnormal
retinal photoreceptor layer apoptotic process increased occurrence , abnormal
Show

 ZFA:0000150 pronephric duct pronephric duct mitotic spindle direction , abnormal
Show

 ZFA:0000151 pronephros pronephros cilium decreased length , abnormal
pronephros epithelial cilium movement arrested , abnormal
pronephros cystic , abnormal
pronephros renal absorption decreased process quality , abnormal
pronephros multi-ciliated epithelial cell lacks parts or has fewer parts of type multi-ciliated epithelial cell cilium, abnormal
pronephros quality , abnormal
Show

 ZFA:0000152 retina retina photoreceptor outer segment absent , abnormal
Show

 ZFA:0000155 somite somite disorganized , abnormal
somite increased width , abnormal
Show

 ZFA:0000168 anterior macula anterior macula stereocilium bundle bent , abnormal
anterior macula stereocilium bundle splayed , abnormal
Show

 ZFA:0000282 sensory system sensory system quality , abnormal
Show

 ZFA:0000396 nervous system nervous system quality , abnormal
Show

 ZFA:0000678 hair cell anterior macula hair cell anterior macula apoptotic process increased occurrence , abnormal
hair cell anterior macula stereocilium decreased amount , abnormal
hair cell anterior macula cilium decreased length , abnormal
Show

 ZFA:0001032 rhombomere 4 rhombomere 4 branchiomotor neuron mislocalised , abnormal
Show

 ZFA:0001086 muscle pioneer muscle pioneer decreased amount , abnormal
Show

 ZFA:0001094 whole organism whole organism curved ventral , abnormal
whole organism curved , abnormal
whole organism anterior-posterior axis curved , abnormal
whole organism shape , abnormal
whole organism anterior-posterior axis shortened , abnormal
whole organism anterior side disorganized , abnormal
Show

 ZFA:0001115 trunk trunk curved , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved ventral , abnormal
post-vent region curved , abnormal
Show

 ZFA:0001135 neural tube neural tube axoneme absent , abnormal
neural tube lacks all parts of type neural tube axoneme, abnormal
Show

 ZFA:0001287 renal tubule renal tubule dilated , abnormal
Show

 ZFA:0001464 retinal outer nuclear layer retinal outer nuclear layer perforate , abnormal
retinal outer nuclear layer eye photoreceptor cell apoptotic , abnormal
Show

 ZFA:0001616 atrioventricular canal endocardium atrioventricular canal endocardium decreased amount , abnormal
Show

 ZFA:0005059 trabecular layer trabecular layer absent , abnormal
Show

 ZFA:0007037 posterior neural tube posterior neural tube cilium decreased amount , abnormal
Show

 ZFA:0009116 slow muscle cell slow muscle cell decreased amount , abnormal
Show

 ZFA:0009127 photoreceptor cell photoreceptor cell decreased amount , abnormal
photoreceptor cell ciliary basal body mislocalised , abnormal
Show

 ZFA:0009154 eye photoreceptor cell eye photoreceptor cell cilium absent , abnormal
eye photoreceptor cell photoreceptor outer segment absent , abnormal
eye photoreceptor cell photoreceptor inner segment membrane disorganized , abnormal
eye photoreceptor cell nucleus decreased length , abnormal
eye photoreceptor cell photoreceptor connecting cilium absent , abnormal
eye photoreceptor cell photoreceptor inner segment membrane displaced , abnormal
eye photoreceptor cell apoptotic , abnormal
Show

 ZFA:0009222 blue sensitive photoreceptor cell blue sensitive photoreceptor cell morphology , abnormal
Show

 ZFA:0009262 retinal cone cell retinal cone cell decreased length , abnormal
retinal cone cell morphology , abnormal
retinal cone cell decreased amount , abnormal
retinal cone cell absence due to degeneration , abnormal
Show

 ZFA:0009275 retinal rod cell retinal rod cell morphology , abnormal
retinal rod cell pigmented , abnormal
retinal rod cell decreased amount , abnormal
retinal rod cell absence due to degeneration , abnormal
Show

 ZFA:0009367 neuromast hair cell neuromast hair cell decreased amount , ameliorated
neuromast hair cell kinocilium absent , abnormal
neuromast hair cell import across plasma membrane process efficacy , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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