ENSDARG00000028688


Danio rerio

Features
Gene ID: ENSDARG00000028688
  
Biological name :exosc2
  
Synonyms : exosc2 / exosome component 2
  
Possible biological names infered from orthology : Exosome complex component RRP4 / Q13868 / Q8VBV3
  
Species: Danio rerio
  
Chr. number: 5
Strand: 1
Band:
Gene start: 72137331
Gene end: 72143292
  
Corresponding Affymetrix probe sets: Dr.1218.1.S1_at (Zebrafish Array)   NM_001017572_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000124376
NCBI entrez gene - 550234     See in Manteia.
RefSeq - NM_001017572
RefSeq Peptide - NP_001017572
swissprot - F8W3K6
ZFIN ID - ZDB-GENE-050417-27
Ensembl - ENSDARG00000028688
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EXOSC2ENSGALG00000040373Gallus gallus
 EXOSC2ENSG00000130713Homo sapiens
 Exosc2ENSMUSG00000039356Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004088  K Homology domain, type 1
 IPR012340  Nucleic acid-binding, OB-fold
 IPR025721  Exosome complex component, N-terminal domain
 IPR026699  Exosome complex RNA-binding protein 1/RRP40/RRP4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000467 exonucleolytic trimming to generate mature 3"-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
 biological_processGO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3"-5" IBA
 biological_processGO:0034475 U4 snRNA 3"-end processing IBA
 biological_processGO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay IBA
 biological_processGO:0071034 CUT catabolic process IBA
 biological_processGO:0071035 nuclear polyadenylation-dependent rRNA catabolic process IBA
 biological_processGO:0071038 nuclear polyadenylation-dependent tRNA catabolic process IBA
 biological_processGO:0071049 nuclear retention of pre-mRNA with aberrant 3"-ends at the site of transcription IBA
 biological_processGO:0071051 polyadenylation-dependent snoRNA 3"-end processing IBA
 cellular_componentGO:0000176 nuclear exosome (RNase complex) IBA
 cellular_componentGO:0000177 cytoplasmic exosome (RNase complex) IBA
 cellular_componentGO:0000178 exosome (RNase complex) IEA
 molecular_functionGO:0003723 RNA binding IBA


Pathways (from Reactome)
Pathway description
mRNA decay by 3 to 5 exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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