ENSMUSG00000039356


Mus musculus

Features
Gene ID: ENSMUSG00000039356
  
Biological name :Exosc2
  
Synonyms : Exosc2 / Exosome complex component RRP4 / Q8VBV3
  
Possible biological names infered from orthology : exosome component 2 / Q13868
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: B
Gene start: 31670715
Gene end: 31681349
  
Corresponding Affymetrix probe sets: 10471191 (MoGene1.0st)   1426630_at (Mouse Genome 430 2.0 Array)   1446994_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118770
Ensembl peptide - ENSMUSP00000141404
Ensembl peptide - ENSMUSP00000043519
NCBI entrez gene - 227715     See in Manteia.
MGI - MGI:2385133
RefSeq - NM_144886
RefSeq - XM_006497944
RefSeq Peptide - NP_659135
swissprot - A2AV19
swissprot - Q3TKQ3
swissprot - Q8VBV3
swissprot - A0A0A6YW57
Ensembl - ENSMUSG00000039356
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 exosc2ENSDARG00000028688Danio rerio
 EXOSC2ENSGALG00000040373Gallus gallus
 EXOSC2ENSG00000130713Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004088  K Homology domain, type 1
 IPR012340  Nucleic acid-binding, OB-fold
 IPR025721  Exosome complex component, N-terminal domain
 IPR026699  Exosome complex RNA-binding protein 1/RRP40/RRP4
 IPR036612  K Homology domain, type 1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000467 exonucleolytic trimming to generate mature 3"-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3"-5" IBA
 biological_processGO:0034475 U4 snRNA 3"-end processing IBA
 biological_processGO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay IBA
 biological_processGO:0071034 CUT catabolic process IBA
 biological_processGO:0071035 nuclear polyadenylation-dependent rRNA catabolic process IBA
 biological_processGO:0071038 nuclear polyadenylation-dependent tRNA catabolic process IBA
 biological_processGO:0071049 nuclear retention of pre-mRNA with aberrant 3"-ends at the site of transcription IBA
 biological_processGO:0071051 polyadenylation-dependent snoRNA 3"-end processing IBA
 cellular_componentGO:0000176 nuclear exosome (RNase complex) IBA
 cellular_componentGO:0000177 cytoplasmic exosome (RNase complex) IBA
 cellular_componentGO:0000178 exosome (RNase complex) IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003723 RNA binding IEA


Pathways (from Reactome)
Pathway description
mRNA decay by 3 to 5 exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr