ENSDARG00000036987


Danio rerio

Features
Gene ID: ENSDARG00000036987
  
Biological name :has2
  
Synonyms : has2 / hyaluronan synthase 2
  
Possible biological names infered from orthology : P70312 / Q92819
  
Species: Danio rerio
  
Chr. number: 16
Strand: -1
Band:
Gene start: 15369634
Gene end: 15387459
  
Corresponding Affymetrix probe sets: Dr.10465.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000053753
NCBI entrez gene - 260350     See in Manteia.
swissprot - Q9DG41
ZFIN ID - ZDB-GENE-020828-1
Ensembl - ENSDARG00000036987
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HAS2ENSGALG00000029596Gallus gallus
 HAS2ENSG00000170961Homo sapiens
 Has2ENSMUSG00000022367Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
has3 / hyaluronan synthase 3 / O00219* / O08650* / Mus musculus hyaluronan synthase 3 (Has3), transcript variant 2, mRNA.*ENSDARG0000005721062
has1 / hyaluronan synthase 1 / Q61647* / Q92839*ENSDARG0000004298355


Protein motifs (from Interpro)
Interpro ID Name
 IPR029044  Nucleotide-diphospho-sugar transferases


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IGI
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003146 heart jogging IGI
 biological_processGO:0003171 atrioventricular valve development IGI
 biological_processGO:0003181 atrioventricular valve morphogenesis IMP
 biological_processGO:0007155 cell adhesion IBA
 biological_processGO:0008078 mesodermal cell migration IMP
 biological_processGO:0021535 cell migration in hindbrain IMP
 biological_processGO:0030213 hyaluronan biosynthetic process IBA
 biological_processGO:0031101 fin regeneration IMP
 biological_processGO:0035050 embryonic heart tube development IMP
 biological_processGO:0035810 positive regulation of urine volume ISS
 biological_processGO:0036302 atrioventricular canal development IGI
 biological_processGO:0042074 cell migration involved in gastrulation IMP
 biological_processGO:0045226 extracellular polysaccharide biosynthetic process IBA
 biological_processGO:0060030 dorsal convergence IGI
 biological_processGO:0070295 renal water absorption ISS
 biological_processGO:0085029 extracellular matrix assembly IBA
 biological_processGO:2000223 regulation of BMP signaling pathway involved in heart jogging IMP
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane NAS
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0050501 hyaluronan synthase activity IBA


Pathways (from Reactome)
Pathway description
Hyaluronan biosynthesis and export


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000115 heart rudiment heart rudiment rotated , abnormal
heart rudiment mislocalised , abnormal
heart rudiment bilateral symmetry , abnormal
Show

 ZFA:0000131 neural keel neural keel increased width , abnormal
Show

 ZFA:0001135 neural tube neural tube epithelium duplicated , abnormal
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 ZFA:0001269 regenerating fin regenerating fin decreased length , abnormal
regenerating fin cell proliferation decreased occurrence , abnormal
regenerating fin lepidotrichium segment decreased length , abnormal
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 ZFA:0001315 atrioventricular canal atrioventricular canal endocardium decreased length , abnormal
atrioventricular canal increased width , abnormal
Show

 ZFA:0001317 endocardial cushion endocardial cushion poorly differentiated , abnormal
Show

 ZFA:0001318 cardiac jelly cardiac jelly decreased volume , abnormal
Show

 ZFA:0001616 atrioventricular canal endocardium atrioventricular canal endocardium endothelial cell scaly , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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