ENSMUSG00000022367


Mus musculus

Features
Gene ID: ENSMUSG00000022367
  
Biological name :Has2
  
Synonyms : Has2 / Hyaluronan synthase 2 / P70312
  
Possible biological names infered from orthology : Q92819
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: D1
Gene start: 56665627
Gene end: 56694539
  
Corresponding Affymetrix probe sets: 10428707 (MoGene1.0st)   1418678_at (Mouse Genome 430 2.0 Array)   1449169_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000062212
NCBI entrez gene - 15117     See in Manteia.
MGI - MGI:107821
RefSeq - NM_008216
RefSeq Peptide - NP_032242
swissprot - P70312
Ensembl - ENSMUSG00000022367
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 has2ENSDARG00000036987Danio rerio
 HAS2ENSGALG00000029596Gallus gallus
 HAS2ENSG00000170961Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Has3 / O08650 / Mus musculus hyaluronan synthase 3 (Has3), transcript variant 2, mRNA. / O00219* / hyaluronan synthase 3*ENSMUSG0000003191070
Has1 / Q61647 / Hyaluronan synthase 1 / Q92839*ENSMUSG0000000366553


Protein motifs (from Interpro)
Interpro ID Name
 IPR001173  Glycosyltransferase 2-like
 IPR028371  Hyaluronan synthase 2
 IPR029044  Nucleotide-diphospho-sugar transferases


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0007155 cell adhesion IBA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010838 positive regulation of keratinocyte proliferation IEA
 biological_processGO:0014911 positive regulation of smooth muscle cell migration IEA
 biological_processGO:0030212 hyaluronan metabolic process IMP
 biological_processGO:0030213 hyaluronan biosynthetic process ISO
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0035810 positive regulation of urine volume IEA
 biological_processGO:0036120 cellular response to platelet-derived growth factor stimulus IEA
 biological_processGO:0036302 atrioventricular canal development IMP
 biological_processGO:0044849 estrous cycle IEA
 biological_processGO:0045226 extracellular polysaccharide biosynthetic process IDA
 biological_processGO:0051549 positive regulation of keratinocyte migration IEA
 biological_processGO:0060349 bone morphogenesis IMP
 biological_processGO:0070295 renal water absorption IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071498 cellular response to fluid shear stress IEA
 biological_processGO:0085029 extracellular matrix assembly IDA
 biological_processGO:0090500 endocardial cushion to mesenchymal transition IMP
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IEA
 biological_processGO:1900127 positive regulation of hyaluronan biosynthetic process IEA
 biological_processGO:1900625 positive regulation of monocyte aggregation IEA
 biological_processGO:1901201 regulation of extracellular matrix assembly IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0050501 hyaluronan synthase activity ISO


Pathways (from Reactome)
Pathway description
Hyaluronan biosynthesis and export


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grid2Lc-J/Grid2+
Genetic Background: involves: 129X1/SvJ * BALB/cByJ * C57BL/6

Allelic Composition: Has2tm1.1Chg/Has2tm1.2Chg,Tg(Hoxb6-cre)#Mku/0
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * FVB/N * SJL

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Has2tm1.1Chg/Has2tm1.2Chg,Tg(Hoxb6-cre)#Mku/0
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * FVB/N * SJL

 MP:0000166 abnormal chondrocyte morphology "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Grid2Lc-J/Grid2+
Genetic Background: involves: 129X1/SvJ * BALB/cByJ * C57BL/6

 MP:0000167 reduced chondrocyte numbers "fewer than normal numbers of nondividing cartilage cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61509]
Show

Allelic Composition: Grid2Lc-J/Grid2+
Genetic Background: involves: 129X1/SvJ * BALB/cByJ * C57BL/6

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000296 absent ventricular trabeculae "missing supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:45302]
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Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000298 absent endocardial cushion "absence of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [MGI:CLS]
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Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Grid2Lc-J/Grid2+
Genetic Background: involves: 129X1/SvJ * BALB/cByJ * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Grid2Lc-J/Grid2+
Genetic Background: involves: 129X1/SvJ * BALB/cByJ * C57BL/6

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
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Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001691 abnormal somite shape "atypical characteristic surface configuration of a segmental mass along the notochord of the developing embryo" [J:37888]
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Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
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Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
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Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001724 abnormal extraembryonic endoderm formation "malformation of the endoderm of the extraembryonic tissue that appears prior to gastrulation and performs critical functions during embryogenesis including nutrient uptake and transport from the mother to the embryo" [J:62628]
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Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Has2tm1.1Chg/Has2tm1.2Chg,Tg(Hoxb6-cre)#Mku/0
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * FVB/N * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Runx1tm2.1(Runx1/Mecom)Homy/Runx1+
Genetic Background: B6.129P2-Runx1tm2.1(Runx1/Mecom)Homy

 MP:0002932 abnormal joint "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Grid2Lc-J/Grid2+
Genetic Background: involves: 129X1/SvJ * BALB/cByJ * C57BL/6

Allelic Composition: Has2tm1.1Chg/Has2tm1.2Chg,Tg(Hoxb6-cre)#Mku/0
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * FVB/N * SJL

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Grid2Lc-J/Grid2+
Genetic Background: involves: 129X1/SvJ * BALB/cByJ * C57BL/6

 MP:0003649 reduced right ventricle 
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Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004055 atrial hypoplasia "reduction in cell number of one or both of the two upper chambers of the heart" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:36567]
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Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005306 abnormal phalanx morphology "aberrant structure of any of the long bones of the digits" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grid2Lc-J/Grid2+
Genetic Background: involves: 129X1/SvJ * BALB/cByJ * C57BL/6

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grid2Lc-J/Grid2+
Genetic Background: involves: 129X1/SvJ * BALB/cByJ * C57BL/6

 MP:0006280 abnormal digit development "anomaly in the formation of the digits" [J:70592, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grid2Lc-J/Grid2+
Genetic Background: involves: 129X1/SvJ * BALB/cByJ * C57BL/6

 MP:0006397 disorganized long bone epiphyseal plate "a lack of the regular arrangement of the cells or zones of the epiphyseal plate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Grid2Lc-J/Grid2+
Genetic Background: involves: 129X1/SvJ * BALB/cByJ * C57BL/6

 MP:0006399 abnormal long bone epiphyseal ossification zone morphology "any anomaly in the structure of the layer of the epiphyseal plate where new bone matrix is deposited" [CALnet tutorial:http://137.222.110.150/calnet/Introanat/Introanat.htm, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Grid2Lc-J/Grid2+
Genetic Background: involves: 129X1/SvJ * BALB/cByJ * C57BL/6

 MP:0008825 abnormal cardiac epithelial to mesenchymal transition "anomaly in the process by which endocardial cells of the atrioventricular canal lose their epithelial characteristics, delaminante from the endocardial sheet, become migratory and invade the cardiac jelly, and develop mesenchymal characteristics eventaully forming the endocardial cushions reqired for septum and atrioventricular valve formation" [PMID:17303760]
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Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010655 absent cardiac jelly "absence of the gelatinous noncellular material between the endothelial lining and the myocardial layer of the developing heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011260 abnormal head mesenchyme morphology "any structural anomaly of the primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells" [ISBN:0-683-40008-8]
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Allelic Composition: Cckartm1Kym/Cckartm1Kym,Cckbrtm1Tom/Cckbrtm1Tom
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011261 abnormal limb mesenchyme morphology "any structural anomaly in the primordial embryonic connective tissue of the developing limbs, autopods and digits, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to limb connective tissue, bone and musculature in conjunction with myotome cells" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Has2tm1.1Chg/Has2tm1.2Chg,Tg(Hoxb6-cre)#Mku/0
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * FVB/N * SJL

 MP:0014105 abnormal chondrocyte differentiation "any anomaly in the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte" [GO:0002062]
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Allelic Composition: Has2tm1.1Chg/Has2tm1.2Chg,Tg(Hoxb6-cre)#Mku/0
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * FVB/N * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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