ENSDARG00000037433


Danio rerio

Features
Gene ID: ENSDARG00000037433
  
Biological name :fmr1
  
Synonyms : fmr1 / fragile X mental retardation 1
  
Possible biological names infered from orthology : Q06787
  
Species: Danio rerio
  
Chr. number: 14
Strand: 1
Band:
Gene start: 20156477
Gene end: 20191281
  
Corresponding Affymetrix probe sets: Dr.10644.1.A1_s_at (Zebrafish Array)   Dr.19208.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000104665
swissprot - F1R159
ZFIN ID - ZDB-GENE-020731-6
Ensembl - ENSDARG00000037433
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FMR1ENSGALG00000009177Gallus gallus
 FMR1ENSG00000102081Homo sapiens
 Fmr1ENSMUSG00000000838Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
fxr1 / fragile X mental retardation, autosomal homolog 1 / Q61584* / P51114* / FMR1 autosomal homolog 1* / Fragile X mental retardation syndrome-related protein 1 *ENSDARG0000002296851
fxr2 / fragile X mental retardation, autosomal homolog 2 / P51116* / FMR1 autosomal homolog 2*ENSDARG0000001626051


Protein motifs (from Interpro)
Interpro ID Name
 IPR004087  K Homology domain
 IPR004088  K Homology domain, type 1
 IPR008395  Agenet-like domain
 IPR022034  Fragile X-related 1 protein, C-terminal core
 IPR032196  Fragile X-related mental retardation protein, C-terminal region 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007420 brain development IMP
 biological_processGO:0014036 neural crest cell fate specification IMP
 biological_processGO:0021905 forebrain-midbrain boundary formation IMP
 biological_processGO:0048755 branching morphogenesis of a nerve IMP
 biological_processGO:0048812 neuron projection morphogenesis IMP
 biological_processGO:0050890 cognition IMP
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0090365 regulation of mRNA modification IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain mRNA modification increased occurrence , abnormal
brain disorganized , abnormal
brain hydrocephalic , abnormal
Show

 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary morphology , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000101 diencephalon diencephalon ventral region morphology , abnormal
Show

 ZFA:0000106 extension extension decreased size , abnormal
Show

 ZFA:0000110 fourth ventricle fourth ventricle morphology , abnormal
Show

 ZFA:0000135 notochord notochord undulate , abnormal
Show

 ZFA:0000295 trigeminal ganglion trigeminal ganglion has fewer parts of type sensory neuron , abnormal
trigeminal ganglion axon increased branchiness , abnormal
trigeminal ganglion axon terminus increased amount , abnormal
Show

 ZFA:0000304 ventral telencephalon ventral telencephalon morphology , abnormal
Show

 ZFA:0000534 lateral longitudinal fasciculus lateral longitudinal fasciculus decreased length , abnormal
lateral longitudinal fasciculus axon defasciculated , abnormal
Show

 ZFA:0000641 cranial nerve cranial nerve position , abnormal
Show

 ZFA:0001094 whole organism whole organism increased behavioural activity , abnormal
whole organism increased amount , abnormal
whole organism mRNA modification increased occurrence , abnormal
Show

 ZFA:0001114 head head anterior-most region truncated , abnormal
head anterior-most region flattened , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage decreased length , abnormal
Meckels cartilage increased width , abnormal
Meckels cartilage increased angle to whole organism anterior-posterior axis, abnormal
Show

 ZFA:0001259 forebrain ventricle forebrain ventricle morphology , abnormal
Show

 ZFA:0001261 ventricular system ventricular system distended , abnormal
Show

 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage increased angle to basihyal cartilage , abnormal
Show

 ZFA:0005778 hypocretin-secreting neuron hypocretin-secreting neuron synapse assembly increased occurrence , abnormal
Show

 ZFA:0009052 motor neuron motor neuron synapse assembly increased occurrence , abnormal
motor neuron collateral sprouting increased occurrence , abnormal
Show

 ZFA:0009060 cholinergic neuron cholinergic neuron synapse assembly increased occurrence , abnormal
Show

 ZFA:0009150 Rohon-Beard neuron Rohon-Beard neuron axon increased branchiness , abnormal
Rohon-Beard neuron axon terminus increased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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