ENSDARG00000039400


Danio rerio

Features
Gene ID: ENSDARG00000039400
  
Biological name :polr1c
  
Synonyms : polr1c / polymerase (RNA) I polypeptide C
  
Possible biological names infered from orthology : DNA-directed RNA polymerases I and III subunit RPAC1 / O15160 / P52432 / RNA polymerase I subunit C
  
Species: Danio rerio
  
Chr. number: 13
Strand: 1
Band:
Gene start: 28690355
Gene end: 28694924
  
Corresponding Affymetrix probe sets: Dr.3838.1.A1_at (Zebrafish Array)   NM_200566_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000112094
Ensembl peptide - ENSDARP00000114654
NCBI entrez gene - 393538     See in Manteia.
RefSeq - NM_200566
RefSeq Peptide - NP_956860
swissprot - A2ATX2
swissprot - A2ATX1
ZFIN ID - ZDB-GENE-040426-1495
Ensembl - ENSDARG00000039400
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 POLR1CENSGALG00000010349Gallus gallus
 O15160ENSG00000171453Homo sapiens
 P52432ENSMUSG00000067148Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001514  DNA-directed RNA polymerase, 30-40kDa subunit, conserved site
 IPR009025  DNA-directed RNA polymerase, RBP11-like dimerisation domain
 IPR011262  DNA-directed RNA polymerase, insert domain
 IPR011263  DNA-directed RNA polymerase, RpoA/D/Rpb3-type
 IPR033901  DNA-directed RNA polymerases I and III subunit AC40


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006360 transcription by RNA polymerase I IEA
 biological_processGO:0006383 transcription by RNA polymerase III IEA
 biological_processGO:0042254 ribosome biogenesis IMP
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IMP
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:1904888 cranial skeletal system development IMP
 cellular_componentGO:0005666 DNA-directed RNA polymerase III complex IBA
 cellular_componentGO:0005736 DNA-directed RNA polymerase I complex IBA
 molecular_functionGO:0001054 RNA polymerase I activity IBA
 molecular_functionGO:0001056 RNA polymerase III activity IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003899 DNA-directed 5"-3" RNA polymerase activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
B-WICH complex positively regulates rRNA expression
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase I Chain Elongation
RNA Polymerase I Transcription Termination
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary morphology , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000076 swim bladder swim bladder uninflated , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000112 gut gut quality , abnormal
gut hypoplastic , abnormal
Show

 ZFA:0000114 heart heart quality , abnormal
Show

 ZFA:0000123 liver liver quality , abnormal
liver hypoplastic , abnormal
Show

 ZFA:0000250 opercle opercle hypoplastic , abnormal
Show

 ZFA:0000561 parasphenoid parasphenoid ossified , abnormal
Show

 ZFA:0000694 ceratobranchial 5 tooth ceratobranchial 5 tooth hypoplastic , abnormal
Show

 ZFA:0000737 cranium cranium necrotic , abnormal
cranium apoptotic process increased occurrence , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased amount , abnormal
whole organism increased amount , abnormal
whole organism amount , ameliorated
Show

 ZFA:0001114 head head decreased width , abnormal
head pointed , abnormal
head decreased size , abnormal
head morphology , abnormal
head apoptotic , abnormal
head apoptotic , ameliorated
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage decreased size , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton agenesis , abnormal
mandibular arch skeleton decreased size , abnormal
Show

 ZFA:0001273 ventral mandibular arch ventral mandibular arch apoptotic , abnormal
Show

 ZFA:0001306 pharyngeal arch pharyngeal arch decreased amount , abnormal
pharyngeal arch apoptotic , abnormal
pharyngeal arch neural crest cell spatial pattern , abnormal
pharyngeal arch neural crest cell decreased distribution , abnormal
pharyngeal arch hypoplastic , abnormal
Show

 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage decreased size , abnormal
Show

 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage polarity , abnormal
Show

 ZFA:0001405 ethmoid cartilage ethmoid cartilage hypoplastic , abnormal
ethmoid cartilage decreased amount , abnormal
ethmoid cartilage decreased length , abnormal
ethmoid cartilage decreased length , ameliorated
ethmoid cartilage decreased width , abnormal
ethmoid cartilage decreased width , ameliorated
ethmoid cartilage anterior margin emarginate , abnormal
ethmoid cartilage anterior margin emarginate , ameliorated
Show

 ZFA:0001458 cranial cartilage cranial cartilage hypoplastic , abnormal
Show

 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage absent , abnormal
Show

 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage decreased size , abnormal
Show

 ZFA:0001611 pharyngeal arch 2 pharyngeal arch 2 cell proliferation decreased occurrence , abnormal
pharyngeal arch 2 decreased size , abnormal
Show

 ZFA:0001612 pharyngeal arch 1 pharyngeal arch 1 cell proliferation decreased occurrence , abnormal
pharyngeal arch 1 decreased size , abnormal
Show

 ZFA:0001613 pharyngeal arch 3-7 pharyngeal arch 3-7 amount , ameliorated
pharyngeal arch 3-7 decreased amount , abnormal
pharyngeal arch 3-7 has fewer parts of type ectomesenchyme , abnormal
pharyngeal arch 3-7 has fewer parts of type ectomesenchyme , ameliorated
Show

 ZFA:0005509 palate palate morphology , abnormal
Show

 ZFA:0009306 neuroepithelial cell neuroepithelial cell apoptotic , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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